The digital data processing concepts of the LOFT mission

The Large Observatory for X-ray Timing (LOFT) is one of the five mission candidates that were considered by ESA for an M3 mission (with a launch opportunity in 2022 - 2024). LOFT features two instruments: the Large Area Detector (LAD) and the Wide Field Monitor (WFM). The LAD is a 10 m 2 -class instrument with approximately 15 times the collecting area of the largest timing mission so far (RXTE) for the first time combined with CCD-class spectral resolution. The WFM will continuously monitor the sky and recognise changes in source states, detect transient and bursting phenomena and will allow the mission to respond to this. Observing the brightest X-ray sources with the effective area of the LAD leads to enormous data rates that need to be processed on several levels, filtered and compressed in real-time already on board. The WFM data processing on the other hand puts rather low constraints on the data rate but requires algorithms to find the photon interaction location on the detector and then to deconvolve the detector image in order to obtain the sky coordinates of observed transient sources. In the following, we want to give an overview of the data handling concepts that were developed during the study phase.Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91446

Hyper-velocity impact test and simulation of a double-wall shield concept for the Wide Field Monitor aboard LOFT

The space mission LOFT (Large Observatory For X-ray Timing) was selected in 2011 by ESA as one of the candidates for the M3 launch opportunity. LOFT is equipped with two instruments, the Large Area Detector (LAD) and the Wide Field Monitor (WFM), based on Silicon Drift Detectors (SDDs). In orbit, they would be exposed to hyper-velocity impacts by environmental dust particles, which might alter the surface properties of the SDDs. In order to assess the risk posed by these events, we performed simulations in ESABASE2 and laboratory tests. Tests on SDD prototypes aimed at verifying to what extent the structural damages produced by impacts affect the SDD functionality have been performed at the Van de Graaff dust accelerator at the Max Planck Institute for Nuclear Physics (MPIK) in Heidelberg. For the WFM, where we expect a rate of risky impacts notably higher than for the LAD, we designed, simulated and successfully tested at the plasma accelerator at the Technical University in Munich (TUM) a double-wall shielding configuration based on thin foils of Kapton and Polypropylene. In this paper we summarize all the assessment, focussing on the experimental test campaign at TUM.Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91446

Performance Verification of the FlashCam Prototype Camera for the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is a future gamma-ray observatory that is planned to significantly improve upon the sensitivity and precision of the current generation of Cherenkov telescopes. The observatory will consist of several dozens of telescopes with different sizes and equipped with different types of cameras. Of these, the FlashCam camera system is the first to implement a fully digital signal processing chain which allows for a traceable, configurable trigger scheme and flexible signal reconstruction. As of autumn 2016, a prototype FlashCam camera for the medium-sized telescopes of CTA nears completion. First results of the ongoing system tests demonstrate that the signal chain and the readout system surpass CTA requirements. The stability of the system is shown using long-term temperature cycling.Comment: 5 pages, 13 figures, Proceedings of the 9th International Workshop on Ring Imaging Cherenkov Detectors (RICH 2016), Lake Bled, Sloveni

FlashCam: a fully-digital camera for the medium-sized telescopes of the Cherenkov Telescope Array

The FlashCam group is currently preparing photomultiplier-tube based cameras proposed for the medium-sized telescopes (MST) of the Cherenkov Telescope Array (CTA). The cameras are designed around the FlashCam readout concept which is the first fully-digital readout system for Cherenkov cameras, based on commercial FADCs and FPGAs as key components for the front-end electronics modules and a high performance camera server as back-end. This contribution describes the progress of the full-scale FlashCam camera prototype currently under construction, as well as performance results also obtained with earlier demonstrator setups. Plans towards the production and implementation of FlashCams on site are also briefly presented.Comment: 8 pages, 6 figures. In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

Correspondence: No substantial long-term bias in the Cenozoic benthic foraminifera oxygen-isotope record

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Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkage between drug hypersensitivity reactions to several drugs and specific HLA alleles. One of the strongest such genetic associations found has been for the antiviral drug abacavir, which causes severe adverse reactions exclusively in patients expressing the HLA molecular variant B*57:01. Abacavir adverse reactions were recently shown to be driven by drug-specific activation of cytokine-producing, cytotoxic CD8+ T cells that required HLA-B*57:01 molecules for their function. However, the mechanism by which abacavir induces this pathologic T cell response remains unclear. Here we show that abacavir can bind within the F-pocket of the peptide-binding groove of HLA-B*57:01 thereby altering its specificity. This supports a novel explanation for HLA-linked idiosyncratic adverse drug reactions; namely that drugs can alter the repertoire of self-peptides presented to T cells thus causing the equivalent of an alloreactive T cell response. Indeed, we identified specific self-peptides that are presented only in the presence of abacavir, and that were recognized by T cells of hypersensitive patients. The assays we have established can be applied to test additional compounds with suspected HLA linked hypersensitivities in vitro. Where successful, these assays could speed up the discovery and mechanistic understanding of HLA linked hypersensitivities as well as guide the development of safer drugs

Language in international business: a review and agenda for future research

A fast growing number of studies demonstrates that language diversity influences almost all management decisions in modern multinational corporations. Whereas no doubt remains about the practical importance of language, the empirical investigation and theoretical conceptualization of its complex and multifaceted effects still presents a substantial challenge. To summarize and evaluate the current state of the literature in a coherent picture informing future research, we systematically review 264 articles on language in international business. We scrutinize the geographic distributions of data, evaluate the field’s achievements to date in terms of theories and methodologies, and summarize core findings by individual, group, firm, and country levels of analysis. For each of these dimensions, we then put forward a future research agenda. We encourage scholars to transcend disciplinary boundaries and to draw on, integrate, and test a variety of theories from disciplines such as psychology, linguistics, and neuroscience to gain a more profound understanding of language in international business. We advocate more multi-level studies and cross-national research collaborations and suggest greater attention to potential new data sources and means of analysis

The COSPIX mission: focusing on the energetic and obscured Universe

Tracing the formation and evolution of all supermassive black holes, including the obscured ones, understanding how black holes influence their surroundings and how matter behaves under extreme conditions, are recognized as key science objectives to be addressed by the next generation of instruments. These are the main goals of the COSPIX proposal, made to ESA in December 2010 in the context of its call for selection of the M3 mission. In addition, COSPIX, will also provide key measurements on the non thermal Universe, particularly in relation to the question of the acceleration of particles, as well as on many other fundamental questions as for example the energetic particle content of clusters of galaxies. COSPIX is proposed as an observatory operating from 0.3 to more than 100 keV. The payload features a single long focal length focusing telescope offering an effective area close to ten times larger than any scheduled focusing mission at 30 keV, an angular resolution better than 20 arcseconds in hard X-rays, and polarimetric capabilities within the same focal plane instrumentation. In this paper, we describe the science objectives of the mission, its baseline design, and its performances, as proposed to ESA.Comment: 7 pages, accepted for publication in Proceedings of Science, for the 25th Texas Symposium on Relativistic Astrophysics (eds. F. Rieger & C. van Eldik), PoS(Texas 2010)25