Peningkatan Motivasi Dan Hasil Belajar Siswa SMP Pada Materi Getaran Dan Gelombang Dengan Menggunakan Media Tik Slide Powerpoint Dan Demonstrasi Alat Sederhana (Penelitian Di SMP Negeri 2 Meurah Mulia Kabupaten Aceh Utara)

Penelitian ini dilakukan untuk mempelajari dampak perbedaan motivasi dan hasil belajar siswa pada materi getaran dan gelombang melalui penggunaan media TIK slide powerpoint dan alat peraga sederhana dan selanjutnya juga ingin diketahui tanggapan siswa terhadap penggunaan media TIK slide powerpoint dan alat peraga sederhana. Penelitian ini menggunakan metode eksperimen semu (quasi experiment) dengan rancangan pretes dan postes control group design yang dilaksanakan di kelas VIII salah satu SMP Negeri di Kabupaten Aceh Utara pada tahun pelajaran 2013/2014. Pengambilan sampel berdasarkan teknik random sampling. Data dikumpulkan melalui pretes dan postes untuk mengamati peningkatan hasil belajar pembelajaran. Angket digunakan untuk mengetahui tanggapan siswa terhadap penggunaan media TIK slide powerpoint dan alat sederhana. Analisis data menunjukkan bahwa tidak terdapat perbedaan yang signifikan pada motivasi dan hasil belajar antara kelas media TIK slide powerpoint dan alat sederhana pada siswa SMP. Mayoritas siswa kurang merespon positif terhadap media TIK slide powerpoint dan alat sederhana

Impact of Health Care Provider’s Training on Patients’ Communication During Labor at Omdurman Maternity Hospital, Sudan 2011

Background: Comprehensive patient’s health care provider’s (HCP) communication usually increases patients’ participation in their health management on childbirth.Objective: This is a quasi interventional study for assessing impact of health care providers (HCP) training on patient- provider’s communication during childbirth in the labour ward at Omdurman Maternity Hospital during 2011.Material and Methods: A situation analysis was done before training to assess existing practice of providers’ communication skills and patient’s satisfaction. All care providers in labour ward were trained and their practice was assessed before and after training. A ten percent sample of patients delivered in hospital before and after training was used to assess providers’ practice. Results were analyzed using SPSS version 18.Results: Health care providers, included were 225 (120/ 105) and interviewed women were, 4469 (2000/ 2469) before and after training respectively. Before training, patients were informed on onset of labour (76.8%), requested investigations (54.9%), permission for vaginal examination (60.3%) and when given antibiotics (85.1%), which improved significantly after training. No improvement in information on adverse effect of drugs and procedures or taking of an informed consent. Patient’s opinion on health care providers’ behavior after delivery in labour ward, were supportive, friendly and respectful (89.7%) and (94.6%) with improved satisfaction (89.8%) and (95.7%) before and after training respectively.Conclusion: The study showed that training of health care providers on communication skills has effective improvement on HCP knowledge and practice towards communication with patients in many areas during labour with resulting good patient’s satisfaction. However, improvement in communication skills need sustained in-service training.Key words: patients- providers’ communication, satisfaction, Sudan

Analisis Miskonsepsi Fisika Dengan Two-Tier Diagnostic Test Dilengkapi Certainty Of Response Index (CRI) Pada Siswa Kelas X Ilmu Pengetahuan Alam Sekolah Menengah Atas Negeri 1 Muaro Jambi

Mengidentifikasi miskonsepsi atau ketidaksesuaian konsep harus dilakukan sedini mungkin agar tidak menyebabkan terjadinya ketidaksesuaian konsep yang berkelanjutan pada materi-materi fisika yang lain. Penelitian ini bertujuan untuk mengetahui tingkat miskonsepsi peserta didik di SMA Negeri 1 Muaro Jambi dan penyebab miskonsepsi. Metode penelitian yang digunakan adalah metode penelitian campuran (mixed-method research) dengan tahap awal yaitu metode kuantitatif dan dilanjutkan metode kualitatif. Pengumpulan data dilakukan terhadap 154 siswa kelas X MIPA SMA Negeri 1 Muaro Jambi menggunakan instrumen berupa tes diagnostik berformat two-tier (dua tingkat) disertai tingkat keyakinan siswa dan wawancara. Teknik sampling pada metode kuantitatif adalah total sampling dan pada metode kualitatif adalah purposive sampling. Hasil penelitian menunjukkan bahwa rata-rata miskonsepsi yang dialami siswa pada materi Hukum Newton tentang Gerak digolongkan dalam kategori sedang karena >30% yaitu sebesar 51.65%

The proteomic landscape of glioma stem-like cells

AbstractGlioma stem-like cells (GSCs) are hypothesized to provide a repository of cells in tumors that can self-replicate and are radio- and chemo-resistant. GSC lines, representing several glioma subtypes, have been isolated and characterized at the transcript level. We sought to characterize 35 GSC lines at the protein level using label-free quantitative proteomics. Resulting relative fold changes were used to drive unsupervised hierarchical clustering for the purpose of classifying the cell lines based on proteomic profiles. Bioinformatics analysis identified synoviolin, serine/arginine-rich splicing factor 2, symplekin, and IL-5 as molecules of interest in progression and/or treatment of glioma

Sequence analysis of the VSX1 and SOD1 genes in families with Keratoconus and a review of the literature

AbstractObjectiveKeratoconus (KC) is a non-inflammatory disorder of the cornea in which the cornea becomes thin and conical, inducing myopia and irregular astigmatism and resulting in mild to marked impairment of vision. The present study was designed to screen two candidate KC genes to identify pathogenic sequence variants responsible for KC in Saudi families.MethodsPeripheral blood samples from members of five Saudi families with KC from the Northern region were collected. Genomic DNA was isolated, and bidirectional sequencing was performed of all coding exons of VSX1 and SOD1 genes using Sanger sequencing.ResultsAll five of the KC families showed a pattern of autosomal recessive inheritance. Phenotyping of these families was performed by a senior ophthalmologist. Sequence analysis of the VSX1 and SOD1 genes failed to reveal any pathogenic sequence variant that could account for KC in the affected individuals.ConclusionOur failure to detect sequence variants in two of the known KC associated genes triggers an interest in other known KC candidate genes, including miR-184, DOCK9, IL1RN and SLC4A11. Future genotyping with dense SNP arrays followed by exome sequencing in these families will be a useful approach to identify the gene(s) underlying KC in this Saudi cohort, which may be different from those reported elsewhere

Palladium nanoparticles by electrospinning from poly(acrylonitrile-co-acrylic acid)-PdCl2 solutions. Relations between preparation conditions, particle size, and catalytic activity

Catalytic palladium (Pd) nanoparticles on electrospun copolymers of acrylonitrile and acrylic acid (PAN-AA) mats were produced via reduction of PdCl2 with hydrazine. Fiber mats were electrospun from homogeneous solutions of PAN-AA and PdCl2 in dimethylformamide (DMF). Pd cations were reduced to Pd metals when fiber mats were treated in an aqueous hydrazine solution at room temperature. Pd atoms nucleate and form small crystallites whose sizes were estimated from the peak broadening of X-ray diffraction peaks. Two to four crystallites adhere together and form agglomerates. Agglomerate sizes and fiber diameters were determined by scanning and transmission electron microscopy. Spherical Pd nanoparticles were dispersed homogeneously on the electrospun nanofibers. The effects of copolymer composition and amount of PdCl2 on particle size were investigated. Pd particle size mainly depends on the amount of acrylic acid functional groups and PdCl2 concentration in the spinning solution. Increasing acrylic acid concentration on polymer chains leads to larger Pd nanoparticles. In addition, Pd particle size becomes larger with increasing PdCl2 concentration in the spinning solution. Hence, it is possible to tune the number density and the size of metal nanoparticles. The catalytic activity of the Pd nanoparticles in electrospun mats was determined by selective hydrogenation of dehydrolinalool (3,7-dimethyloct-6- ene-1-yne-3-ol, DHL) in toluene at 90 °C. Electrospun fibers with Pd particles have 4.5 times higher catalytic activity than the current Pd/Al2O3 catalyst

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF

Targeted cancer therapies have revolutionized treatment but their efficacies are limited by the development of resistance driven by clonal evolution within tumors. We developed CAPTURE , a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resistant cells for in-depth multi-omics analysis and functional exploration. We demonstrate that heterogeneous clones, either preexisting or emerging from drug-tolerant persister cells, dominated resistance to vemurafenib in BRA

Metal oxide–zeolite composites in transformation of methanol to hydrocarbons : do iron oxide and nickel oxide matter?

The methanol-to-hydrocarbon (MTH) reaction has received considerable attention as utilizing renewable sources of both value-added chemicals and fuels becomes a number one priority for society. Here, for the first time we report the development of hierarchical zeolites (ZSM-5) containing both iron oxide and nickel oxide nanoparticles. By modifying the iron oxide (magnetite, Fe3O4) amounts, we are able to control the catalyst activity and the product distribution in the MTH process. At the medium Fe3O4 loading, the major fraction is composed of C9–C11 hydrocarbons (gasoline fraction). At the higher Fe3O4 loading, C1–C4 hydrocarbons prevail in the reaction mixture, while at the lowest magnetite loading the major component is the C5–C8 hydrocarbons. Addition of Ni species to Fe3O4–ZSM-5 leads to the formation of mixed Ni oxides (NiO/Ni2O3) positioned either on top of or next to Fe3O4 nanoparticles. This modification allowed us to significantly improve the catalyst stability due to diminishing coke formation and disordering of the coke formed. The incorporation of Ni oxide species also leads to a higher catalyst activity (up to 9.3 g(methanol)/(g(ZSM-5) × h)) and an improved selectivity (11.3% of the C5–C8 hydrocarbons and 23.6% of the C9–C11 hydrocarbons), making these zeolites highly promising for industrial applications

Multiple models and experiments underscore large uncertainty in soil carbon dynamics

Soils contain more carbon than plants or the atmosphere, and sensitivities of soil organic carbon (SOC) stocks to changing climate and plant productivity are a major uncertainty in global carbon cycle projections. Despite a consensus that microbial degradation and mineral stabilization processes control SOC cycling, no systematic synthesis of long-term warming and litter addition experiments has been used to test process-based microbe-mineral SOC models. We explored SOC responses to warming and increased carbon inputs using a synthesis of 147 field manipulation experiments and five SOC models with different representations of microbial and mineral processes. Model projections diverged but encompassed a similar range of variability as the experimental results. Experimental measurements were insufficient to eliminate or validate individual model outcomes. While all models projected that CO efflux would increase and SOC stocks would decline under warming, nearly one-third of experiments observed decreases in CO flux and nearly half of experiments observed increases in SOC stocks under warming. Long-term measurements of C inputs to soil and their changes under warming are needed to reconcile modeled and observed patterns. Measurements separating the responses of mineral-protected and unprotected SOC fractions in manipulation experiments are needed to address key uncertainties in microbial degradation and mineral stabilization mechanisms. Integrating models with experimental design will allow targeting of these uncertainties and help to reconcile divergence among models to produce more confident projections of SOC responses to global changes. 2

Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact.

UNLABELLED: Glioblastoma (GBM) is the most aggressive human brain tumor. Although several molecular subtypes of GBM are recognized, a robust molecular prognostic marker has yet to be identified. Here, we report that the stemness regulator Sox2 is a new, clinically important target of microRNA-21 (miR-21) in GBM, with implications for prognosis. Using the MiR-21-Sox2 regulatory axis, approximately half of all GBM tumors present in the Cancer Genome Atlas (TCGA) and in-house patient databases can be mathematically classified into high miR-21/low Sox2 (Class A) or low miR-21/high Sox2 (Class B) subtypes. This classification reflects phenotypically and molecularly distinct characteristics and is not captured by existing classifications. Supporting the distinct nature of the subtypes, gene set enrichment analysis of the TCGA dataset predicted that Class A and Class B tumors were significantly involved in immune/inflammatory response and in chromosome organization and nervous system development, respectively. Patients with Class B tumors had longer overall survival than those with Class A tumors. Analysis of both databases indicated that the Class A/Class B classification is a better predictor of patient survival than currently used parameters. Further, manipulation of MiR-21-Sox2 levels in orthotopic mouse models supported the longer survival of the Class B subtype. The MiR-21-Sox2 association was also found in mouse neural stem cells and in the mouse brain at different developmental stages, suggesting a role in normal development. Therefore, this mechanism-based classification suggests the presence of two distinct populations of GBM patients with distinguishable phenotypic characteristics and clinical outcomes. SIGNIFICANCE STATEMENT: Molecular profiling-based classification of glioblastoma (GBM) into four subtypes has substantially increased our understanding of the biology of the disease and has pointed to the heterogeneous nature of GBM. However, this classification is not mechanism based and its prognostic value is limited. Here, we identify a new mechanism in GBM (the miR-21-Sox2 axis) that can classify ∼50% of patients into two subtypes with distinct molecular, radiological, and pathological characteristics. Importantly, this classification can predict patient survival better than the currently used parameters. Further, analysis of the miR-21-Sox2 relationship in mouse neural stem cells and in the mouse brain at different developmental stages indicates that miR-21 and Sox2 are predominantly expressed in mutually exclusive patterns, suggesting a role in normal neural development