Effect of ACTH and CRH on Plasma Levels of Cortisol and Prostaglandin F(2α )Metabolite in Cycling Gilts and Castrated Boars

The present study was designed to evaluate the effects of synthetic ACTH (1–24, tetracosactid) and porcine CRH on the plasma levels of cortisol and PGF(2α )metabolite in cycling gilts (n = 3) and castrated boars (n = 3). The experiments were designed as crossover studies for each gender separately. Each animal received, during three consecutive days; 1) ACTH (Synacthen(® )Depot) at a dose of 10 μg/kg body weight in 5 ml physiological saline, 2) porcine CRH at a dose 0.6 μg/kg body weight in 5 ml physiological saline or 3) physiological saline (5 ml). The test substances were administered via an indwelling jugular cannula in randomized order according to a Latin square. The administration of ACTH to cycling gilts resulted in concomitant elevations of cortisol and PGF(2α )metabolite with peak levels reached at 70.0 ± 10.0 and 33.3 ± 6.7 min, respectively. Similarly, the administration of ACTH to castrated boars resulted in concomitant elevation of cortisol and PGF(2α )metabolite with peak levels reached at 60.0 ± 0.0 and 20.0 ± 0.0 min, respectively. Cortisol peaked at 20 min after administration of CRH in both cycling gilts and castrated boars with maximum levels of 149.3 ± 16.5 nmol/1 and 138.3 ± 10.1 nmol/1, respectively. It can be concluded that administration of synthetic ACTH (tetracosactid) to pigs caused a concomitant elevation of cortisol and PGF(2α )metabolite levels in both cycling gilts as well as castrated boars. The administration of CRH to pigs resulted in an elevation of cortisol levels in both cycling gilts and castrated boars. Conversely, PGF(2α )metabolite levels were not influenced by the administration of CRH either in cycling gilts or in castrated boars

Health Education Needs for Mortality Surveillance in Machakos County, Kenya

Reporting mortality information is the primary data source from which evidence can be drawn to monitor disease trends and inform public health policy to improve population health. Still, only two-thirds of expected annual deaths are reported globally. Health education and promotion play a significant role in empowering communities to uptake public health services such as mortality surveillance. This qualitative descriptive study aimed to understand health workers’ (HWs’) perspectives regarding the need for health education to support mortality surveillance in Machakos County, Kenya. The capabilities, opportunities, and motivation for the behavior change model guided the study. Semi-structured interviews were used to collect data from 10 participants based on their involvement in death registration activities, training as HWs, and participation in health education activities. Findings from coding and thematic analysis indicated formal education and training about death registration were rarely or never provided to community members or HWs, who learned about mortality surveillance on the job. Opportunities for educating community members about the importance of death registration healthcare tasks were reported. HWs who attended community meetings were allowed time to talk to people regarding the significance of registering their dead. Death prevention was the strongest motivation for reporting deaths. The findings indicated the need for a curriculum and educational material for healthcare workers and communities on the importance of mortality surveillance. Findings may enable the Machakos County government health department to enrich HWs’ training by integrating health education on mortality surveillance

Health Education Needs for Mortality Surveillance in Machakos County, Kenya

Reporting mortality information is the primary data source from which evidence can be drawn to monitor disease trends and inform public health policy to improve population health. Still, only two-thirds of expected annual deaths are reported globally. Health education and promotion play a significant role in empowering communities to uptake public health services such as mortality surveillance. This qualitative descriptive study aimed to understand health workers’ (HWs’) perspectives regarding the need for health education to support mortality surveillance in Machakos County, Kenya. The capabilities, opportunities, and motivation for the behavior change model guided the study. Semi-structured interviews were used to collect data from 10 participants based on their involvement in death registration activities, training as HWs, and participation in health education activities. Findings from coding and thematic analysis indicated formal education and training about death registration were rarely or never provided to community members or HWs, who learned about mortality surveillance on the job. Opportunities for educating community members about the importance of death registration healthcare tasks were reported. HWs who attended community meetings were allowed time to talk to people regarding the significance of registering their dead. Death prevention was the strongest motivation for reporting deaths. The findings indicated the need for a curriculum and educational material for healthcare workers and communities on the importance of mortality surveillance. Findings may enable the Machakos County government health department to enrich HWs’ training by integrating health education on mortality surveillance

Impact of Postovulatory Food Deprivation on the Ova Transport, Hormonal Profiles and Metabolic Changes in Sows

The effect of food deprivation on ova transport, hormonal profiles and metabolic changes was studied in 20 crossbred multiparous sows during their second oestrus after weaning. To determine the time of ovulation, transrectal ultrasonographic examination was performed. The sows were divided into 2 groups, one control group (C-group), which was fed according to Swedish standards, and one experimental group (E-group). The E-group sows were deprived of food from the first morning meal after ovulation until slaughter. Blood samples were collected every second hour from about 12 h before expected ovulation in the second oestrus after weaning until slaughter and were analysed for progesterone, prostaglandin F2α-metabolite, insulin, glucose, free fatty acids and triglycerides. All sows were slaughtered approximately 48 h after ovulation and the genital tract was recovered. The isthmic part of the oviduct was divided into 3 equally long segments and flushed separately with phosphate buffered saline (PBS). Uterine horns were also flushed with PBS. A significantly greater number of ova were found in the first and second part of the isthmus in the E-group (p = 0.05) while in the C-group most of the ova were found in the third part of the isthmus or the uterus (p = 0.01). The level of prostaglandin F2α-metabolite was significantly higher in the E-group compared with the C-group. The concentration of progesterone increased in both groups after ovulation but there were no significant differences between the groups. The other blood parameters showed that the food-deprived sows were in a catabolic state. The 48 h period of fasting results, directly or indirectly in an delayed ova transport, which may be due to a delayed relaxation in the smooth circular muscle layer of the isthmus

Attitudes of primary health care providers towards people with mental illness: evidence from two districts in Zambia

Written in conjunction with the Mental Health and Poverty Project Research Programme ConsortiumObjective: The aim of this study was to explore health care providers’ attitudes towards people with mental illness within two districts in Zambia. It sought to document types of attitudes of primary health care providers towards people suffering from mental illness and possible predictors of such attitudes. This study offers insights into how health care providers regard people with mental illness that may be helpful in designing appropriate training or re-training programs in Zambia and other low-income African countries. Method: Using a pilot tested structured questionnaire, data were collected from a total of 111 respondents from health facilities in the two purposively selected districts in Zambia that the Ministry of Health has earmarked as pilot districts for integrating mental health into primary health care. Results: There are widespread stigmatizing and discriminatory attitudes among primary health care providers toward mental illness and those who suffer from it. These findings confirm and add weight to the results from the few other studies which have been conducted in Africa that have challenged the notion that stigma and discrimination of mental illness is less severe in African countries. Conclusion: There is an urgent need to start developing more effective awareness-raising, training and education programmes amongst health care providers. This will only be possible if there is increased consensus, commitment and political will within government to place mental health on the national agenda and secure funding for the sector. These steps are essential if the country is improve the recognition, diagnosis and treatment of mental disorders, and realize the ideals enshrined in the progressive health reforms undertaken over the last decade.Key words: Mental health; Stigma; Discrimination; Primary health care giver

A global perspective on the influence of environmental exposures on the nervous system

Economic transitions in the era of globalization warrant a fresh look at the neurological risks associated with environmental change. These are driven by industrial expansion, transfer and mobility of goods, climate change and population growth. In these contexts, risk of infectious and non-infectious diseases are shared across geographical boundaries. In low- and middle-income countries, the risk of environmentally mediated brain disease is augmented several fold by lack of infrastructure, poor health and safety regulations, and limited measures for environmental protection. Neurological disorders may occur as a result of direct exposure to chemical and/or non-chemical stressors, including but not limited to, ultrafine particulate matters. Individual susceptibilities to exposure-related diseases are modified by genetic, epigenetic and metagenomic factors. The existence of several uniquely exposed populations, including those in the areas surrounding the Niger Delta or north western Amazon oil operations; those working in poorly regulated environments, such as artisanal mining industries; or those, mostly in sub-Saharan Africa, relying on cassava as a staple food, offers invaluable opportunities to advance the current understanding of brain responses to environmental challenges. Increased awareness of the brain disorders that are prevalent in low- and middle-income countries and investments in capacity for further environmental health-related research are positive steps towards improving human health

Assessment of solar energy source distribution and potential in Zambia

Zambia is vastly endowed with a wide range of energy resources. Yet, to date, Zambia has not fully exploited its potential in solar energy utilisation for electricity generation due to various reasons such as lack of understanding of the distribution of solar energy potential in the country and limitation of access to solar energy resource information. This paper assess the solar energy distribution and potential in Zambia. Nine provinces with different geographical and climatic regions that makes up Zambia were assesed. The distribution of solar radiation within the country were assessed using spatial analysis in ArcGIS Software. The 22year period solar datasets were considered for assessment. These datasets were obtained from NASA Atmospheric Science Data Center using Surface Meteorology and Solar Energy. The analyzed results indicate that Zambia has approximately 20,442TWh/year technical solar energy potential and receives 2109.97kWh/m2 of solar energy per year with 4403.12hours of sunshine. The country has 186,121km2 available and suitable land area for RETs implementations. This study is important as it present an overview of the technical solar energy potential for Zambia which is vital for decision making, energy mix and sustainable deployment of solar energy technologies in the countr

The potential of solar energy for sustainable water resource development and averting national social burden in rural areas of Zambia

About 50% of the Zambia’s population in the rural areas do not have access to an improved source of water supply, thus relies on untreated water from shallow wells, streams and rivers for drinking and other activities. The lack of access to clean water is associated with water related illnesses and other negative social impacts. This paper aimed to propose use of solar energy in water pumping systems for water supply in rural areas of Zambia. The information used is from secondary sources. Use of the solar energy in water pumping system is not only an important part of providing household with clean drinking water alternative, but also important for access to an improved source of water supply for rural households and sustainable water resource development in Zambia. The paper further investigates the potential of using solar energy in water pumping system to avert the nation’s disease burden and its sustainability using number of employment created as indicator. The analyzed results indicates that the use of solar energy in water pumping systems have the potential of reducing the Zambia’s social cost burden by 30% which translate to about US$61million saving per year and can create employment of about 24,000 in Zambia

Mental illness - stigma and discrimination in Zambia

Objective: The aim of this qualitative study was to explore the presence, causes and means of addressing individual and systemic stigma and discrimination against people with mental illness in Zambia. This is to facilitate the development of tailor-made antistigma initiatives that are culturally sensitive for Zambia and other low-income African countries. This is the first in-depth study on mental illness stigma in Zambia. Method: Fifty semi-structured interviews and 6 focus group discussions were conducted with key stakeholders drawn from 3 districts in Zambia (Lusaka, Kabwe and Sinazongwe). Transcripts were analyzed using a grounded theory approach. Results: Mental illness stigma and discrimination is pervasive across Zambian society, prevailing within the general community, amongst family members, amid general and mental health care providers, and at the level of government. Such stigma appears to be fuelled by misunderstandings of mental illness aetiology; fears of contagion and the perceived dangerousness of people with mental illness; and associations between HIV/AIDS and mental illness. Strategies suggested for reducing stigma and discrimination in Zambia included education campaigns, the transformation of mental health policy and legislation and expanding the social and economic opportunities of the mentally ill. Conclusion: In Zambia, as in many other lowincome African countries, very little attention is devoted to addressing the negative beliefs and behaviours surrounding mental illness, despite the devastating costs that ensue. The results from this study underscore the need for greater commitment from governments and policy-makers in African countries to start prioritizing mental illness stigma as a major public health and development issue.Key words: Mental health; Stigma and discrimination; Qualitative study; Zambi

Fatigue crack shielding in plain bearings under large scale yielding

Multi-layered bearing systems used in the automotive industry show shielding and antishielding effects that reduce or amplify the crack driving force under large-scale yielding conditions. Using finite element analysis, it is shown that shielding in such systems results in path deflection and bifurcation despite the absence of mixed-mode loading. As the crack approaches a stiff layer, the tangential strains measured around a blunted crack tip model show a maximum corresponding to the direction of crack propagation. The distribution of such strains indicates the effect of shielding and the likelihood of the tip to deflect or bifurcate.The suitability of bi-layer and tri-layer bearing architectures is assessed through crack path and respective crack driving force prediction