Uso potencial e toxidez da torta de pinhão-manso.

A expansão do cultivo do pinhão-manso é crescente, e vai de encontro com a necessidade do uso de fontes alternativas de óleo para a produção de biodiesel. O aproveitamento da torta de pinhão manso para a ração animal, da mesma forma como ocorre para o farelo de soja, geraria importante renda e viabilizaria economicamente a cultura. A torta, no entanto, possui diversos compostos tóxicos/antinutricinais, que devem ser mais bem conhecidos, tanto para questões de saúde pública quanto para que processos de destruição dos mesmos possam ser racionalmente desenvolvidos. O presente trabalho vem apresentar um levantamento dos casos de intoxicação pela planta e seu tratamento atual, dando uma visão realista e sem alarmismo dos riscos. Além disso, apresenta quais as estratégias a Embrapa tem estudado para destoxificação da torta para seu uso em ração animal.bitstream/item/17903/1/cot_01-1.pd

Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding

There continues to be a major effort in the United States to develop mitigators for the treatment of mass casualties that received high-intensity acute ionizing radiation exposures from the detonation of an improvised nuclear device during a radiological terrorist attack. The ideal countermeasure should be effective when administered after exposure, and over a wide range of absorbed doses. We have previously shown that the administration of a subcutaneous incision of a defined length, if administered within minutes after irradiation, protected young adult female C57BL/6 mice against radiation-induced lethality, and increased survival after total-body exposure to an LD50/30 X-ray dose from 50% to over 90%. We refer to this approach as "protective wounding". In this article, we report on our efforts to further optimize, characterize and demonstrate the validity of the protective wounding response by comparing the response of female and male mice, varying the radiation dose, the size of the wound, and the timing of wounding with respect to administration of the radiation dose. Both male and female mice that received a subcutaneous incision after irradiation were significantly protected from radiation lethality. We observed that the extent of protection against lethality after an LD50/30 X-ray dose was independent of the size of the subcutaneous cut, and that a 3 mm subcutaneous incision is effective at enhancing the survival of mice exposed to a broad range of radiation doses (LD15-LD100). Over the range of 6.2-6.7 Gy, the increase in survival observed in mice that received an incision was associated with an enhanced recovery of hematopoiesis. The enhanced rate of recovery of hematopoiesis was preceded by an increase in the production of a select group of cytokines. Thus, a thorough knowledge of the timing of the cytokine cascade after wounding could aid in the development of novel pharmacological radiation countermeasures that can be administered several days after the actual radiation exposure

Substâncias tóxicas, alergênicas e antinutricionais presentes no pinhão-manso e seus derivados e procedimentos adequados ao manuseio.

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Pesquisa e desenvolvimento para aproveitamento da torta de pinhão-manso na alimentação animal.

O pinhão manso A torta de pinhão manso Tratamentos físico- químicos da torta de pinhão-manso Tratamento Físico- químicos da torta de pinhão-manso Tratamento microbiano da torta de pinhão-manso Melhoramento microbiano da torta de pinhão-manso Melhoramento genético para cultivares com baixos teores de ésteres de forbol Digestibilidade da torta tóxica de pinhão-manso Perspectivas.bitstream/item/61930/1/Folder-destoxificacao-pinhao-manso-2012.pd

Using Near Infrared Spectroscopy to Access Muscle Post-exercise Oxygen Debt

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Jatropha curcas cake: Detoxification process of Jatropha curcas cake.

Degradation process of toxic compounds (phorbol esters) present in Jatropha curcas cake by cultivation of macrofungi, with formation of bioactive metabolites (polysaccharides, proteins, sterols, among others) in the pretreated biomass.TC 176