PINE-TREE enables efficient enrichment of prime-edited hPSCs

Commentary PINE-TREE enables efficient enrichment of prime-edited hPSC

Obtaining Practical Information on the Geology of Texas

Information, like gold, is where you find it. Geological information is no exception, but in Texas such data are often readily at hand. The state has one of the highest concentrations of practicing geologists per capita in the United States; and Texans in general are very conscious of the importance of fossil fuels, earth materials, and land and water resources in the state's economy, history, and quality of life. But where does one turn for specific geological information? Fortunately, there are many sources of information on the geology of Texas, including: 1) State agencies 2) Federal agencies 3) Colleges and universities 4) Geological (and related) societies 5) Museums and nature centers 6) Oil, mining, and consulting companies 7) Public schools 8) Public libraries These organizations can often provide published information, films, lectures, and professional advice to persons requiring particular information as well as those who simply have a sincere interest in the geosciences. Most of the state and federal agencies, colleges and universities, and geological societies that engage in studies of the geology of Texas are listed in the accompanying appendices (A, B, C, and D), along with their addresses, telephone numbers, and summary statements of their areas of involvement or expertise.Bureau of Economic Geolog

Market Reaction to the Adoption of IFRS in Europe

This study examines the European stock market reaction to sixteen events associated with the adoption of International Financial Reporting Standards (IFRS) in Europe. European IFRS adoption represented a major milestone towards financial reporting convergence yet spurred controversy reaching the highest levels of government. We find a more positive reaction for firms with lower quality pre-adoption information, which is more pronounced in banks, and with higher pre-adoption information asymmetry, consistent with investors expecting net information quality benefits from IFRS adoption. We also find that the reaction is less positive for firms domiciled in code law countries, consistent with investors' concerns over enforcement of IFRS in those countries. Finally, we find a positive reaction to IFRS adoption events for firms with high quality pre-adoption information, consistent with investors expecting net convergence benefits from IFRS adoption. Overall, the findings suggest that investors in European firms perceived net benefits associated with IFRS adoption.IFRS, IAS 39, Convergence, Europe, Event Study

Synthesis and Study of Olefin Metathesis Catalysts Supported by Redox-Switchable Diaminocarbene 3 Ferrocenophanes

A redox-switchable ligand, N,N'-dimethyldiaminocarbene[3]ferrocenophane (5), was synthesized and incorporated into a series of Ir- and Ru-based complexes. Electrochemical and spectroscopic analyses of (5) Ir(CO)(2)Cl (15) revealed that 5 displayed a Tolman electronic parameter value of 2050 cm(-1) in the neutral state and 2061 cm(-1) upon oxidation. Moreover, inspection of X-ray crystallography data recorded for (5) Ir(cis,cis-1,5-cyclooctadiene)Cl (13) revealed that 5 was sterically less bulky (%V-Bur = 28.4) than other known diaminocarbene[3]ferrocenophanes, which facilitated the synthesis of (5)(PPh3)Cl2Ru-(3-phenylindenylid-1-ene) (18). Complex 18 exhibited quasi-reversible electrochemical processes at 0.79 and 0.98 V relative to SCE, which were assigned to the Fe and Ru centers in the complex, respectively, based on UV-vis and electron pair resonance spectroscopic measurements. Adding 2,3-dichloro-5,6-dicyanoquinone over the course of a ring-opening metathesis polymerization of cis, cis-1,5-cyclooctadiene catalyzed by 18 ([monomer](0)/[18](0) = 2500) reduced the corresponding rate constant of the reaction by over an order of magnitude (pre-oxidation: k(obs) = 0.045 s(-1); post-oxidation: k(obs) = 0.0012 s(-1)). Subsequent reduction of the oxidized species using decamethylferrocene restored catalytic activity (post-reduction: k(obs) = up to 0.016 s(-1), depending on when the reductant was added). The difference in the polymerization rates was attributed to the relative donating ability of the redox-active ligand (i.e., strongly donating 5 versus weakly donating 5(+)) which ultimately governed the activity displayed by the corresponding catalyst.U. S. Army Research Office W911NF-09-1-0446Chemistr

16: A Research‐Based Rubric for Developing Statements of Teaching Philosophy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138851/1/tia200512.pd

Increased white matter fibre dispersion and lower IQ scores in adults born preterm

Preterm birth has been associated with altered microstructural properties of the white matter and lower cognitive ability in childhood and adulthood. Due to methodological limitations of the diffusion tensor model, it is not clear whether alterations in myelination or variation in fibre orientation are driving these differences. Novel models applied to multi-shell diffusion imaging have been used to disentangle these effects, but to date this has not been used to study the preterm brain in adulthood. This study investigated whether novel advanced diffusion MRI metrics such as microscopic anisotropy and orientation dispersion are altered in adults born preterm, and whether this was associated with cognitive performance. Seventy-two preterm born participants (37 weeks gestational age) controls (34 males, mean age 30.9 ± 4.0 years) were recruited from the general population. Tensor FA was calculated with FSL, while microscopic FA and orientation dispersion entropy (ODE) were estimated using the Spherical Mean Technique (SMT). Estimated Full Scale IQ (FSIQ), Verbal Comprehension Index (VCI) and Perceptual Reasoning Index (PRI) were obtained from the WASI-II (abbreviated) IQ test. Voxel-wise comparisons using FSL's tract-based spatial statistics were performed to test between-group differences in diffusion MRI metrics as well as within-group associations of diffusion MRI metrics and IQ outcomes. The preterm group had significantly lower FSIQ, VCI and PRI scores. Preterm subjects demonstrated widespread decreases in ODE reflecting increased fibre dispersion, but no differences in microscopic FA. Tensor FA was increased in a small area in the anterior corona radiata. Lower FA values in the preterm population were associated with lower FSIQ and PRI scores. An increase in fibre dispersion in white matter and lower IQ scores after preterm birth exist in adulthood. Advanced diffusion MRI metrics such as the orientation dispersion entropy can be used to monitor white matter alterations across the lifespan in preterm born individuals. Although not significantly different between preterm and term groups, tensor FA values in the preterm group were associated with cognitive outcome

An Analysis of Spatio-Temporal Landscape Patterns for Protected Areas in Northern New England: 1099-2010

Context: Landscape ecology theory provides insight about how large assemblages of protected areas (PAs) should be configured to protect biodiversity. We adapted these theories to evaluate whether the emergence of decentralized land protection in a largely private landscape followed the principles of reserve design. Objectives: Our objectives were to determine: (1) Are there distinct clusters of PAs in time and space? (2) Are PAs becoming more spatially clustered through time? and (3) Does the resulting PA portfolio have traits characteristic of ideal reserve design? Methods: We developed an historical dataset of the PAs enacted since 1900 in the northern New England region of the US. We conducted spatio-temporal clustering, landscape pattern, and aggregation analyses at both the landscape scale and for specific classes of land ownership, conservation method, and degree of protection. Results: We found the frequency of PAs increased through time, and that area-weighted clusters of PAs were heavily influenced by a few recent large PAs. PA clustering around preexisting PAs was driven primarily by establishment of large PAs focused on natural resource management, rather than strict reserves. Since 1990, the complete portfolio has increased in aggregation, but reserve patches have become less aggregated and smaller, while patches that allow extractive uses have become more aggregated and larger. Conclusions: Our extension of landscape ecology theory to a diverse portfolio of PAs underscores the importance of prioritizing conservation choices in the context of existing PAs, and elucidates the landscape scale effects of individual actions within a portfolio of protected areas

An Analysis of Spatio-Temporal Landscape Patterns for Protected Areas in Northern New England: 1099-2010

Context: Landscape ecology theory provides insight about how large assemblages of protected areas (PAs) should be configured to protect biodiversity. We adapted these theories to evaluate whether the emergence of decentralized land protection in a largely private landscape followed the principles of reserve design. Objectives: Our objectives were to determine: (1) Are there distinct clusters of PAs in time and space? (2) Are PAs becoming more spatially clustered through time? and (3) Does the resulting PA portfolio have traits characteristic of ideal reserve design? Methods: We developed an historical dataset of the PAs enacted since 1900 in the northern New England region of the US. We conducted spatio-temporal clustering, landscape pattern, and aggregation analyses at both the landscape scale and for specific classes of land ownership, conservation method, and degree of protection. Results: We found the frequency of PAs increased through time, and that area-weighted clusters of PAs were heavily influenced by a few recent large PAs. PA clustering around preexisting PAs was driven primarily by establishment of large PAs focused on natural resource management, rather than strict reserves. Since 1990, the complete portfolio has increased in aggregation, but reserve patches have become less aggregated and smaller, while patches that allow extractive uses have become more aggregated and larger. Conclusions: Our extension of landscape ecology theory to a diverse portfolio of PAs underscores the importance of prioritizing conservation choices in the context of existing PAs, and elucidates the landscape scale effects of individual actions within a portfolio of protected areas

A Research–Based Rubric for Developing Statements of Teaching Philosophy

Despite its ubiquity as the way that instructors represent their views on teaching and learning, the statement of teaching philosophy can be a frustrating document to write and the results are often uneven. This chapter describes a rubric created at the University of Michigan’s Center for Research on Learning and Teaching to help faculty and graduate students craft teaching statements. We describe the research that informed the creation of the rubric, talk about how we use the rubric in our consultations and workshops, and present an assessment that validates the use of the rubric to improve instructors’ teaching statements