Structural and RF properties of niobium films deposited onto annealed niobium resonators

Studies have been performed on the properties of niobium thin films sputtered onto solid niobium TM010 resonators at 1.5 GHz. The purpose of the work is to study the behaviour of the film's RF and str uctural properties as a function of heat treatment temperature in order to determine if and at what treatment temperature the properties of the films merge with those of the bulk. Niobium resonators h ave been heat treated at temperatures up to 1100°C in a vacuum furnace inside a niobium box surrounded by a titanium gettering protection. Subsequently, they have been sputter coated with a niobium fi lm. Following RF measurements of the coated resonators, the cavities have undergone heat treatments as described above at 800°C, 900°C, 1000°C and 1100°C, each time followed by RF measurements. Before heat treatment, the RF response of the film was similar to that of a film coated on a copper substrate. A marked transition towards bulk-like RF behaviour was observed after the 900°C treatment. The c hanges include a sharp variation of the BCS resistance and of the sensitivity to externally applied magnetic field, quantities believed to be closely linked to the amount and nature of defects in the coating

Anatomy of terminal moraine segments and implied lake stability on Ngozumpa Glacier, Nepal, from electrical resistivity tomography (ERT)

This research was supported financially by the European Commission FP7-MC-IEF (PIEF-GA-2012-330805), the University Centre in Svalbard (UNIS), National Geographic Society GRANT #W135-10.Moraine-dammed lakes at debris-covered glaciers are becoming increasingly common and pose significant outburst flood hazards if the dam is breached. While moraine subsurface structure and internal processes are likely to influence dam stability, only few sites have so far been investigated. We conducted electrical resistivity tomography (ERT) surveys at two sites on the terminal moraine complex of the Ngozumpa Glacier, Nepal, to aid assessment of future terminus stability. The resistivity signature of glacier ice at the site (100-15 kΩ m) is more consistent with values measured from cold glacier ice and while this may be feasible, uncertainties in the data inversion introduce ambiguity to this thermal interpretation. However, the ERT data does provide a significant improvement to our knowledge of the subsurface characteristics at these sites, clearly showing the presence (or absence) of glacier ice. Our interpretation is that of a highly complex latero-terminal moraine, resulting from interaction between previous glacier advance, recession and outburst flooding. If the base-level Spillway Lake continues to expand to a fully formed moraine-dammed glacial lake, the degradation of the ice core could have implications for glacial lake outburst risk.Publisher PDFPeer reviewe

Metabolism of synthetic cannabinoid receptor agonists encountered in clinical casework: major in vivo phase I metabolites of JWH-007, JWH-019, JWH-203, JWH-307, UR-144, XLR-11, AM-2201, MAM-2201 and AM-694 in human urine using LC-MS/MS

Background: `Herbal mixtures` containing synthetic cannabinoid receptor agonists (SCRAs) are promoted as legal alternative to marihuana and are easily available via the Internet. Keeping analytical methods for the detection of these SCRAs up-to-date is a continuous challenge for clinicians and toxicologists due to the high diversity of the chemical structures and the frequent emergence of new compounds. Since many SCRAs are extensively metabolized, analytical methods used for urine testing require previous identification of the major metabolites of each compound. Objective: The aim of this study was to identify the in vivo major metabolites of nine SCRAs (AM-694, AM-2201, JWH-007, JWH-019, JWH-203, JWH-307, MAM-2201, UR-144, XLR-11) for unambiguous detection of a drug uptake by analysis of urine samples. Method: Positive urine samples from patients of hospitals, detoxification and therapy centers as well as forensic-psychiatric clinics were analyzed by means of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and liquid chromatography-quadrupol time-of-flight mass spectrometry (LC-qToF-MS) for investigation of the in vivo major metabolites. Results: For all investigated SCRAs, monohydroxylation, dihydroxylation and/or formation of the N-pentanoic acid metabolites were among the most abundant metabolites detected in human urine samples. Substitution of the fluorine atom was observed to be an important metabolic reaction for compounds carrying an N-(5-fluoropentyl) chain. Dealkylated metabolites were not detected in vivo. Conclusion: The investigated metabolites facilitate the reliable detection of drug uptake by analysis of urine samples. For distinction between uptake of the fluorinated and the non-fluorinated analogs, the N-(4-hydroxypentyl) metabolite of the non-fluorinated analog was identified as a useful analytical target and consumption marker

Flux pinning characteristics in cylindrical ingot niobium used in superconducting radio frequency cavity fabrication

We present the results of from DC magnetization and penetration depth measurements of cylindrical bulk large-grain (LG) and fine-grain (FG) niobium samples used for the fabrication of superconducting radio frequency (SRF) cavities. The surface treatment consisted of electropolishing and low temperature baking as they are typically applied to SRF cavities. The magnetization data were fitted using a modified critical state model. The critical current density Jc and pinning force Fp are calculated from the magnetization data and their temperature dependence and field dependence are presented. The LG samples have lower critical current density and pinning force density compared to FG samples which implies a lower flux trapping efficiency. This effect may explain the lower values of residual resistance often observed in LG cavities than FG cavities

Low temperature laser scanning microscopy of a superconducting radio-frequency cavity

An apparatus was developed to obtain, for the first time, 2D maps of the surface resistance of the inner surface of an operating superconducting radio-frequency niobium cavity by a low-temperature laser scanning microscopy technique. This allows identifying non-uniformities of the surface resistance with a spatial resolution of about one order of magnitude better than with earlier methods and surface resistance resolution of ~ 1 micro-Ohm at 3.3 GHz. A signal-to-noise ratio of about 10 dB was obtained with 240 mW laser power and 1 Hz modulation frequency. The various components of the apparatus, the experimental procedure and results are discussed in detail in this contribution.Comment: 19 pages, 17 figures, submitted to Rev. Sci. Instru

Kohlenstoffbilanzen von renaturierten Hangmooren im Hunsrück, Rheinland-Pfalz

In Moorböden ist ein Großteil des terrestrischen Kohlenstoffs gespeichert. Drainage für land- oder forstwirtschaftliche Nutzung von Mooren führt zu einer Freisetzung von Kohlenstoff aus dem Boden in die Atmosphäre. Renaturierung von genutzten Mooren ist ein weitverbreitetes Steuerungsinstrument um die Treibhausgasemissionen von Moorböden zu reduzieren. Dieses Projekt zielt darauf ab, die Kohlenstoffbilanzen von renaturierten Hangmooren zu quantifizieren. Die sogenannten Hangbrücher im Nationalpark Hunsrück-Hochwald sind charakteristisch für die Region. Sie wurden seit dem 19. Jahrhundert mit Gräben für die forstwirtschaftliche Nutzung (Fichte) entwässert. Seit einigen Jahren werden sie im Rahmen von verschiedenen Projekten durch Grabenverschlüsse wiedervernässt. Außerdem wurde die Entnahme von standortsfremder Bestockung mittels Seilkran durchgeführt. Sechs Moore mit unterschiedlichen Degradierungsstadien wurden ausgewählt und verschiedene bodenchemische, -physikalische und -hydrologische Parameter aufgenommen. Die Ausdehnung der Moorflächen und die Kohlenstoffvorräte (Boden und Holz) werden erfasst und in ein Moorkataster überführt. Geoelektrische Sondierungen und Kartierungen werden zur Charakterisierung des oberflächennahen Untergrundes der Moorwälder und Hangmoore sowie zur Erfassung der hydrologischen Situation der Moorstandorte durchgeführt. Des Weiteren werden luftgestützte Laserscanaufnahmen für hochaufgelöste Geländemodelle und eine Abschätzung des Holzvorrates der Moore verwendet. Das Gesamtziel einer flächendeckenden Kohlenstoffbilanzierung wird erreicht, indem wir auf der Grundlage des Moorkatasters ein Upscaling der Kohlenstoffvorräte bei unterschiedlichen Renaturierungsszenarien durchführen. Das Moorkataster bietet außerdem die Möglichkeit die erhobenen Daten für ein Langzeitmonitoring der Flächen zu nutzen und dient dabei als Grundlage für weitere Untersuchungen

Successful user operation of a superconducting radio-frequency photoelectron gun with Mg cathodes

At the electron linac for beams with high brilliance and low emittance (ELBE) center for high-power radiation sources, the second version of a superconducting radio-frequency (SRF) photoinjector has been put into operation and has been routinely applied for user operation at the ELBE electron accelerator. SRF guns are suitable for generating a continuous wave electron beam with high average currents and high beam brightness. The SRF gun at ELBE has the goal to generate short electron pulses with bunch charges of 200–300 pC at typical repetition rates of 100 kHz for the production of superradiant, coherent terahertz radiation. The SRF gun includes a 3.5-cell, 1.3-GHz niobium cavity and a superconducting solenoid. A support system with liquid nitrogen (LN2) cooling allows the operation of normal-conducting, high quantum efficiency photocathodes. We present the design and performance of the SRF gun as well as beam measurement results of the operation with Mg photocathodes at an acceleration gradient of 8  MV/m (4 MeV kinetic energy). In the last section, we discuss the SRF gun application for production of coherent terahertz radiation at the ELBE facility

Cannabinoid Receptor 2 Signaling Does Not Modulate Atherogenesis in Mice

BACKGROUND:Strong evidence supports a protective role of the cannabinoid receptor 2 (CB(2)) in inflammation and atherosclerosis. However, direct proof of its involvement in lesion formation is lacking. Therefore, the present study aimed to characterize the role of the CB(2) receptor in Murine atherogenesis. METHODS AND FINDINGS:Low density lipoprotein receptor-deficient (LDLR(-/-)) mice subjected to intraperitoneal injections of the selective CB(2) receptor agonist JWH-133 or vehicle three times per week consumed high cholesterol diet (HCD) for 16 weeks. Surprisingly, intimal lesion size did not differ between both groups in sections of the aortic roots and arches, suggesting that CB(2) activation does not modulate atherogenesis in vivo. Plaque content of lipids, macrophages, smooth muscle cells, T cells, and collagen were also similar between both groups. Moreover, CB(2) (-/-)/LDLR(-/-) mice developed lesions of similar size containing more macrophages and lipids but similar amounts of smooth muscle cells and collagen fibers compared with CB(2) (+/+)/LDLR(-/-) controls. While JWH-133 treatment reduced intraperitoneal macrophage accumulation in thioglycollate-elicited peritonitis, neither genetic deficiency nor pharmacologic activation of the CB(2) receptor altered inflammatory cytokine expression in vivo or inflammatory cell adhesion in the flow chamber in vitro. CONCLUSION:Our study demonstrates that both activation and deletion of the CB(2) receptor do not relevantly modulate atherogenesis in mice. Our data do not challenge the multiple reports involving CB(2) in other inflammatory processes. However, in the context of atherosclerosis, CB(2) does not appear to be a suitable therapeutic target for reduction of the atherosclerotic plaque

Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling Pathway

Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity. Loss of checkpoint function is an early event in tumorigenesis. Polo kinases (Plks) are fundamental regulators of cell cycle progression in all eukaryotes and are frequently overexpressed in tumors. Through their polo box domain, Plks target multiple substrates previously phosphorylated by CDKs and MAPKs. In response to DNA damage, Plks are temporally inhibited in order to maintain the checkpoint-dependent cell cycle block while their activity is required to silence the checkpoint response and resume cell cycle progression. Here, we report that, in budding yeast, overproduction of the Cdc5 polo kinase overrides the checkpoint signaling induced by double strand DNA breaks (DSBs), preventing the phosphorylation of several Mec1/ATR targets, including Ddc2/ATRIP, the checkpoint mediator Rad9, and the transducer kinase Rad53/CHK2. We also show that high levels of Cdc5 slow down DSB processing in a Rad9-dependent manner, but do not prevent the binding of checkpoint factors to a single DSB. Finally, we provide evidence that Sae2, the functional ortholog of human CtIP, which regulates DSB processing and inhibits checkpoint signaling, is regulated by Cdc5. We propose that Cdc5 interferes with the checkpoint response to DSBs acting at multiple levels in the signal transduction pathway and at an early step required to resect DSB ends