4,464 research outputs found
Chemical fracture and distribution of extreme values
When a corrosive solution reaches the limits of a solid sample, a chemical
fracture occurs. An analytical theory for the probability of this chemical
fracture is proposed and confirmed by extensive numerical experiments on a two
dimensional model. This theory follows from the general probability theory of
extreme events given by Gumbel. The analytic law differs from the Weibull law
commonly used to describe mechanical failures for brittle materials. However a
three parameters fit with the Weibull law gives good results, confirming the
empirical value of this kind of analysis.Comment: 7 pages, 5 figures, to appear in Europhysics Letter
Data production models for the CDF experiment
The data production for the CDF experiment is conducted on a large Linux PC
farm designed to meet the needs of data collection at a maximum rate of 40
MByte/sec. We present two data production models that exploits advances in
computing and communication technology. The first production farm is a
centralized system that has achieved a stable data processing rate of
approximately 2 TByte per day. The recently upgraded farm is migrated to the
SAM (Sequential Access to data via Metadata) data handling system. The software
and hardware of the CDF production farms has been successful in providing large
computing and data throughput capacity to the experiment.Comment: 8 pages, 9 figures; presented at HPC Asia2005, Beijing, China, Nov 30
- Dec 3, 200
Data processing model for the CDF experiment
The data processing model for the CDF experiment is described. Data
processing reconstructs events from parallel data streams taken with different
combinations of physics event triggers and further splits the events into
datasets of specialized physics datasets. The design of the processing control
system faces strict requirements on bookkeeping records, which trace the status
of data files and event contents during processing and storage. The computing
architecture was updated to meet the mass data flow of the Run II data
collection, recently upgraded to a maximum rate of 40 MByte/sec. The data
processing facility consists of a large cluster of Linux computers with data
movement managed by the CDF data handling system to a multi-petaByte Enstore
tape library. The latest processing cycle has achieved a stable speed of 35
MByte/sec (3 TByte/day). It can be readily scaled by increasing CPU and
data-handling capacity as required.Comment: 12 pages, 10 figures, submitted to IEEE-TN
The effects of experimentally obtained electron correlation and polarization on electron densities and exchange-correlation potentials
In X-ray constrained wavefunction (XCW) fitting, external information, such as electron correlation and polarization, is included into a single-determinantal isolated-molecule wavefunction. In a first step, we show that the extraction of these two physical effects by XCW fitting is complete and accurate by comparing to theoretical reference calculations. In a second step, we show that fitting to data from single-crystal x-ray diffraction measurements provides the same results qualitatively and how the physical effects can be separated, although always inherently convolved in the experiment. We further demonstrate that exchange-correlation potentials are systematically affected by XCW fitting in a physically meaningful way, which could be exploited for method development in quantum chemistry, subject to some remaining challenges that we also outline
Organizational response to disaster -the case of tsunami, December 2004
The Tsunami struck Sri Lanka on 26th December 2004, causing an enormous devastation of humanlives and property. State and non-state sectors being unprepared and poor coordination of internationaland local assistance left people internally displaced even after one year of the disaster. Using primaryand secondary data, the study assessed the responsiveness of the organizations to the Tsunami disasterin the Galle district and developed a model of action for effective disaster management.The study identified the response levels of the organizations at relief, recovery, reconstruction,rehabilitation and development stages. There was no pre-preparation for a major disaster in Galledistrict. The disaster reliefwas provided by unplanned emergent structures. The prevailing administrativestructures, political institutions, Center for National Operations, Non-governmental organizations,volunteers and community-based groups provided relief for two months. The government establishedthe emergency operation structures for national level coordinationAt the recovery stage community and the private sector organizations have been marginalized in theresponse system. Governmental and NGOs have focused on providing transitional shelters and dryrations. The reconstruction and rehabilitation stages have focused on housing, livelihoods, socialrehabilitation and infrastructure, which were in progress through September 2006. The Galle districtemergency operation center completed the Disaster management plan for the district in July 2005.The parliament of Sri Lanka approved the Sri Lanka Disaster Management Act, No 13 of2005, underwhich the National Disaster Management center has been established.The model identifies organizational structure to coordinate donor assistance and link to communityneeds, through national and local level coordinating institutions with the contribution of different sectorsand with proper monitoring. Getting the vulnerable community to actively participate in disastermanagement activities leading towards development will minimize the damage. Suggestions are madefor specific capacity building measures for the different levels of the institutional model
Effective toughness of heterogeneous brittle materials
A heterogeneous brittle material characterized by a random field of local
toughness Kc(x) can be represented by an equivalent homogeneous medium of
toughness, Keff. Homogenization refers to a process of estimating Keff from the
local field Kc(x). An approach based on a perturbative expansion of the stress
intensity factor along a rough crack front shows the occurrence of different
regimes depending on the correlation length of the local toughness field in the
direction of crack propagation. A `"weak pinning" regime takes place for long
correlation lengths, where the effective toughness is the average of the local
toughness. For shorter correlation lengths, a transition to "strong pinning"
occurs leading to a much higher effective toughness, and characterized by a
propagation regime consisting in jumps between pinning configurations
Material-independent crack arrest statistics: Application to indentation experiments
An extensive experimental study of indentation and crack arrest statistics is
presented for four different brittle materials (alumina, silicon carbide,
silicon nitride, glass). Evidence is given that the crack length statistics can
be described by a universal (i.e. material independent) distribution. The
latter directly derives from results obtained when modeling crack propagation
as a depinning phenomenon. Crack arrest (or effective toughness) statistics
appears to be fully characterized by two parameters, namely, an asymptotic
crack length (or macroscopic toughness) value and a power law size dependent
width. The experimental knowledge of the crack arrest statistics at one given
scale thus gives access to its knowledge at all scales
Covalency and ionicity do not oppose each other : relationship between Si-O bond character and basicity of siloxanes
Covalency and ionicity are orthogonal rather than antipodal concepts. We demonstrate for the case of siloxane systems [R3Si-(O-SiR2)(n)-O-SiR3] that both covalency and ionicity of the Si-O bonds impact on the basicity of the Si-O-Si linkage. The relationship between the siloxane basicity and the Si-O bond character has been under debate since previous studies have presented conflicting explanations. It has been shown with natural bond orbital methods that increased hyperconjugative interactions of LP(O)->sigma*(Si-R) type, that is, increased orbital overlap and hence covalency, are responsible for the low siloxane basicity at large Si-O-Si angles. On the other hand, increased ionicity towards larger Si-O-Si angles has been revealed with real-space bonding indicators. To resolve this ostensible contradiction, we perform a complementary bonding analysis, which combines orbital-space, real-space, and bond-index considerations. We analyze the isolated disiloxane molecule H3SiOSiH3 with varying Si-O-Si angles, and n-membered cyclic siloxane systems Si2H4O(CH2)(n-3). All methods from quite different realms show that both covalent and ionic interactions increase simultaneously towards larger Si-O-Si angles. In addition, we present highly accurate absolute hydrogen-bond interaction energies of the investigated siloxane molecules with water and silanol as donors. It is found that intermolecular hydrogen bonding is significant at small Si-O-Si angles and weakens as the Si-O-Si angle increases until no stable hydrogen-bond complexes are obtained beyond phi(SiOSi) = 168 degrees, angles typically displayed by minerals or polymers. The maximum hydrogen-bond interaction energy, which is obtained at an angle of 105 degrees, is 11.05 kJ mol(-1) for the siloxane-water complex and 18.40 kJ mol(-1) for the siloxane-silanol complex
The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis.
Background
Clostridium difficile infection (CDI) is a major health problem. Epidemiological evidence suggests that there is an association between acid suppression therapy and development of CDI.
Purpose
We sought to systematically review the literature that examined the association between histamine 2 receptor antagonists (H2RAs) and CDI.
Data source
We searched Medline, Current Contents, Embase, ISI Web of Science and Elsevier Scopus from 1990 to 2012 for all analytical studies that examined the association between H2RAs and CDI.
Study selection
Two authors independently reviewed the studies for eligibility.
Data extraction
Data about studies characteristics, adjusted effect estimates and quality were extracted.
Data synthesis
Thirty-five observations from 33 eligible studies that included 201834 participants were analyzed. Studies were performed in 6 countries and nine of them were multicenter. Most studies did not specify the type or duration of H2RAs therapy. The pooled effect estimate was 1.44, 95% CI (1.22–1.7), I2 = 70.5%. This association was consistent across different subgroups (by study design and country) and there was no evidence of publication bias. The pooled effect estimate for high quality studies was 1.39 (1.15–1.68), I2 = 72.3%. Meta-regression analysis of 10 study-level variables did not identify sources of heterogeneity. In a speculative analysis, the number needed to harm (NNH) with H2RAs at 14 days after hospital admission in patients receiving antibiotics or not was 58, 95% CI (37, 115) and 425, 95% CI (267, 848), respectively. For the general population, the NNH at 1 year was 4549, 95% CI (2860, 9097).
Conclusion
In this rigorous systematic review and meta-analysis, we observed an association between H2RAs and CDI. The absolute risk of CDI associated with H2RAs is highest in hospitalized patients receiving antibiotics
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