12 research outputs found
Production and Partial Characterization of Protease from Aspergillus Flavus using Rice Mill Waste as a Substrate and its Comparision with Aspergillus Niger Protease
Abstract Proteases are one of the most important groups of industrial enzymes and occur widely in plants an
Late preterms: A vulnerable group needing due attention
"Late preterms may be apparently normal but a vulnerable group of preterm infants needing due attention both by the Obstetricians and Pediatricians. Late preterms like any other preterms are vulnerable to complications such as Respiratory Distress Syndrome (RDS) and other complications seen in a preterm infant. The American Congress of Obstetricians and Gynecologists guidelines recommend administration of antenatal corticosteroids in a mother in premature labor only up to the gestational age of 34 weeks. This is a case report of a preterm baby with a gestational age of 35 weeks which presented with RDS. We are hereby reporting this case to draw attention of the Obstetricians and Pediatricians toward this entity of ′Late Preterm′ to provide better care to them and obtain better outcomes.
Synthesis, structure-activity relationship of iodinated-4-aryloxymethyl- coumarins as potential anti-cancer and anti-mycobacterial agents
A series of new iodinated-4-aryloxymethylcoumarins 6, 8 and 10 have been obtained from the reaction of various 4-bromomethylcoumarins 4 with 2-iodophenol 5, 3-iodophenol 7 and 4-iodophenol 9 respectively. All the title compounds were screened for anticancer activity against two cancer cell lines (MDA-MB human adenocarcinoma mammary gland and A-549 human lung carcinoma) and two mycobacterial strains (Mycobacterium tuberculosis H37 RV and Mycobacterium phlei). The SAR results indicate that nine compounds are potent, among these 10h and 10i having chlorine are most effective. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure-activity relationship for this new class of iodinated-4-aryloxymethyl-coumarins. © 2014 Elsevier Masson SAS. All rights reserved
Effect of Surface Chemistry on Hemolysis, Thrombogenicity, and Toxicity of Carbon Nanotube Doped Thermally Sprayed Hydroxyapatite Implants
Assessing blood compatibility is crucial before in vivo
procedures
and is considered more reliable than many in vitro tests. This study
examines the physiochemical properties and blood compatibility of
bioactive powders ((0.5–2 wt % carbon nanotube (CNT)/alumina)-20
wt %)) produced through a heterocoagulation colloidal technique followed
by ball milling with hydroxyapatite (HAp). The 1 wt % CNT composite
demonstrated a surface charge ∼5 times higher than HAp at pH
7.4, with a value of −11 mV compared to −2 mV. This
increase in electrostatic charge is desirable for achieving hemocompatibility,
as evidenced by a range of blood compatibility assessments, including
hemolysis, blood clotting, platelet adhesion, platelet activation,
and coagulation assays (prothrombin time (PT) and activated partial
thrombin time (aPTT)). The 1 wt % CNT composite exhibited hemolysis
ranging from 2 to 7%, indicating its hemocompatibility. In the blood
clot investigation, the absorbance values for 1–2 wt % CNT
samples were 0.927 ± 0.038 and 1.184 ± 0.128, respectively,
indicating their nonthrombogenicity. Additionally, the percentage
of platelet adhered on the 1 wt % CNT sample (∼5.67%) showed
a ∼2.5-fold decrement compared to the clinically used negative
control, polypropylene (∼13.73%). The PT and aPTT experiments
showed no difference in the coagulation time for CNT samples even
at higher concentrations, unlike HAC2 (80 mg). In conclusion, the
1 wt % CNT sample was nontoxic to human blood, making it more hemocompatible,
nonhemolytic, and nonthrombogenic than other samples. This reliable
study reduces the need for additional in vitro and in vivo studies
before clinical trials, saving time and cost