Optimalisasi Perlindungan Anak melalui Penetapan Hukuman Kebiri

Judul dari penelitian ini adalah Optimalisasi Perlindungan Anak Melalui Penetapan Hukuman Kebiri. Hukuman kebiri merupakan reaksi dari banyaknya kasus kekerasan seksual pada anak. Permasalahan dalam tulisan ini adalah apakah hukum kebiri merupakan wujud optimalisasi dalam perlindungan anak sesuai dngan amanat Konstitusi Negara Republik Indonesia Tahun 1945 serta Bagaimana serta bagaimana kedudukan pelaksanaan hukuman Kebiri dalam Hukum pidana. Metode yang digunakan adalah metode penelitian yuridis normatif. Analisa yang didapatkan yaitu hukuman kebiri adalah hukuman yang memberikan efek jera juga memberikan ketakutan sehingga tidak akan lagi melakukan perbuatannya.Hukuman kebiri terhadap pelaku kejahatan seksual tidak hanya dengan hukuman tersebut namun juga dengan pemberian sangsi terhadap pelanggaran norma agama dan norma kesusilaa

EBAG9 (Estrogen receptor-binding fragment-associated antigen 9)

Review on EBAG9 (Estrogen receptor-binding fragment-associated antigen 9), with data on DNA, on the protein encoded, and where the gene is implicated

Model Pembelajaran E-Learning Untuk Menunjang Pembelajaran Dengan Kurikulum Yang Berbasis KBK

— Higher education in Indonesia using the Competency Based Curriculum (CBC), which requires learning the process of Teacher-Centered Content-Oriented (TCCO), and not the Student-Centered Learning (SCL). Learning Process TCCO cause educators act as facilitators or motivator. On the other hand the Indonesian government has allowed the implementation of e-learning. E-learning is the use of electronic technology to create a learning experience. An efficient e-Learning system should provide learners with learning environment that has high degree of freedom and should also provide educators with environment that has facilitate their function as facilitator or motivator with many learning methods thus learner's competency can be achieved. In order to realize that, e-Learning systems must be developed with such functions as letting learners choose appropriate learning contents and understand correctly their level of progress and achievement for each learning outcomes. The challenge is how the e-learning system can support Competency Based Curriculum (CBC) system. This paper describes a concept model of e-learning that can support Competency-Based Curriculum (CBC) in higher education. Moodle application that had been used by many organization can't supported all the needs of Competency-Based Curriculum (CBC) learning). In this articles will describe a model for supportin

Existence and uniqueness of near-coupled coincidence points in partial cone-interval metric spaces

This paper introduces a new type of space called partial cone-interval metric space, and explores some of its topological properties. Using a novel fixed-point technique, we investigate the existence and uniqueness of near-coupled coincidence points in this setting. We provide numerical examples to demonstrate the effectiveness of our approach

A Study On Prevention Of Vitamin A Deficiency By Annual Oral Massive Dose Vitamin A And E Emulsion Administration

Suatu penyelidikan mengenai pencegahan dan pengobatan penyakit defisiensi vit. A. di Cibatok, Bogor, telah dilakukan dengan menggunakan oral massive dose vit. A. (retinol palmitat e) 300,000 I.U. dikombinasikan dengan vit E (a tocopherol acetate) 50 I.U. dl. Dua group anak-anak umur 1-6 tahun dipilih masing-masing sebagai group Experiment dan Control yang hanya diberikan placebo. Sedangkan masing-masing group dibagi lagi menjadi golongan-golongan penderita dan golongan Non vit. A. defisiensi (normal). Ternyata setelah 6 (enam) bulan kemudian 90 percent penderita yang mendapat pengobatan menjadi sembuh dan sebaliknya 88.9 percent dari penderita yang mendapat placebo masih tetap menderita defisiensi vit. A. (table 2) Table 3. Menunjukkan adanya pengaruh penyakit infeksi G.I tract terhadap berhasilnya pengobatan dan juga pada umumnya dapat disimpulkan bahwa gizi penderita tidak mempengaruhi pengobatan. Table 4 Kadar Vit. A. didalam darah penderita setelah pengobatan ternyata jauh lebih tinggi dari semula. Sedangkan dalam group yang mendapat placebo tidak terjadi kenaikan. Dari data penyelidikan tersebut dapat disimpulkan bahwa pemberian oral massive dose kombinasi dari vit. A dan E pada anak-anak sebelum sekolah dapat mencegah, mengobati gejala-gejala defisiensi vit. A. di mata

LiST as a catalyst in program planning: experiences from Burkina Faso, Ghana and Malawi

Background African countries are working to achieve rapid reductions in maternal and child mortality and meet their targets for the Millennium Development Goals (MDGs). Partners in the Catalytic Initiative to Save One Million Lives (CI) are assisting them by providing funding and technical assistance to increase and accelerate coverage for proven interventions. Here we describe how the Lives Saved Tool (LiST) was used as part of an early assessment of the expected impact of CI plans in Malawi, Burkina Faso and Ghana

Assessment of Intratumoral Heterogeneity in Isolated Human Primary High-Grade Glioma: Cluster of Differentiation 133 and Cluster of Differentiation 15 Double Staining of Glioblastoma Subpopulations

BACKGROUND: Gliomas are the most common primary brain tumors, representing 50–60% of malignant primary brain tumors. Gliomas are highly heterogeneous with marked inter- and intratumoral diversity. Gliomas heterogeneity is a challenging issue in the development of personalized treatment. The simplest method for studying heterogeneity is using ex vivo cell cultures; in our case, the cell lines were isolated from patient with glioblastomas. AIM: Here, we reported distinct cell subpopulations heterogeneity in glioblastoma cells. METHODS: Human glioblastoma cells isolation is conducted by enzymatic method with combination of collagenase I, hyaluronidase, and trypsin enzyme in proportional amount from patient. Immunostaining was performed to assess glial fibrillary acidic protein (GFAP), Ki-67, isocitrate dehydrogenase-1 (IDH-1) status, and program death ligand-1 (PD-L1) expression. Primary glioblastoma cell line was characterized by flow cytometry (fluorescence-activated cell sorting) analysis based on cluster of differentiation (CD) 133 and CD15 marker expression. U87MG and CGNH-89 cell lines were used as control. Distinct subpopulation analysis was performed by double staining of CD133 and CD15 in isolated primary glioblastoma cell line and its comparative control cells. RESULTS: Our isolated glioblastoma cells morphology was adherent cells which were able to form spheres depending on environment. Immunostaining confirmed GFAP, Ki-67, IDH-1 mutants, and PD-L1 expression. Our isolated glioblastoma cells expressed CD133 and CD15, coexpressed CD133/CD15 in different patterns. The highest subpopulation in primary glioblastoma was CD133+/CD15+. CONCLUSION: Glioblastoma cells can be isolated using enzymatic methods. Isolated glioblastoma cells consist of four different subpopulations distinguished by CD133/CD15 double staining. Intratumoral heterogeneity exists and directly or indirectly depends on their microenvironment

Hubungan Antara Kadar Protein BCL-2 Dan Caspase 3 Sebagai Faktor Risiko Pada Kejadian Abortus

Untuk mengetahui korelasi antara kadar protein Bcl-2 dan caspase-3 pada kehamilan normal dan abortus, serta kekuatan kadar protein Bcl-2 dengan caspase-3 sebagai alat ukur untuk uji diagnostik. Penelitian analitik dengan menggunakan rancangan case control terhadap 38 subjek dengan abortus dan 38 subjek dengan kehamilan normal sebagai kontrol yang memenuhi kriteria inklusi. Untuk melihat keeratan hubungan antara kadar protein Bcl-2 dan caspase-3 dilakukan analisis dengan uji korelasi Pearson, sedangkan untuk uji diagnostik digunakan kurva ROC (Receiver Operating Characteristics). Rerata kadar Bcl-2 pada subjek dengan abortus lebih rendah yaitu 7,263 (SB 1,71) ng/mL, sedangkan kehamilan normal 7,490 (SB 3,938) ng/mL (p=0,050). Rerata kadar caspase-3 pada subjek abortus lebih tinggi yaitu 112,74 (SB 152,73) mg/mL, sedangkan kehamilan normal 14,94 (SB 23,18) mg/mL (p<0,001). Tidak terdapat korelasi bermakna antara kadar protein Bcl-2 dan caspase-3 pada kehamilan normal dan abortus walaupun terlihat kecenderungan semakin meningkat kadar protein Bcl-2 semakin tinggi kadar caspase-3 (r=0,093). Bcl-2 mempunyai cut-off point >6,49 mg/mL (OR=3,58) dan caspase-3 mempunyai cut-off point >11,25 ng/mL (OR=28,63). Tidak terdapat korelasi bermakna antara kadar protein Bcl-2 dan caspase-3 pada kasus abortus (r=0,093). Bcl-2 (cut-off point >6,49 ng/mL) mempunyai kecenderungan abortus 3,58 kali dan caspase-3 (cut-off point >11,25mg/mL) mempunyai kecenderungan abortus 28,63 kali