Capturing magma intrusion and faulting processes during continental rupture: seismicity of the Dabbahu (Afar) rift

Continental rupture models emphasize the role of faults in extensional strain accommodation; extension by dyke intrusion is commonly overlooked. A major rifting episode that began in 2005 September in the Afar depression of Ethiopia provides an opportunity to examine strain accommodation in a zone of incipient plate rupture. Earthquakes recorded on a temporary seismic array (2005 October to 2006 April), direct observation of fault patterns and geodetic data document ongoing strain and continued dyke intrusion along the ?60-km long Dabbahu rift segment defined in earlier remote sensing studies. Epicentral locations lie along a ?3 km wide, ?50 km long swath that curves into the SE flank of Dabbahu volcano; a second strand continues to the north toward Gab'ho volcano. Considering the ?8 m of opening in the September crisis, we interpret the depth distribution of microseismicity as the dyke intrusion zone; the dykes rise from ?10 km to the near-surface along the ?60-km long length of the tectono-magmatic segment. Focal mechanisms indicate slip along NNW-striking normal faults, perpendicular to the Arabia–Nubia plate opening vector. The seismicity, InSAR, continuous GPS and structural patterns all suggest that magma injection from lower or subcrustal magma reservoirs continued at least 3 months after the main episode. Persistent earthquake swarms at two sites on Dabbahu volcano coincide with areas of deformation identified in the InSAR data: (1) an elliptical, northwestward-dipping zone of seismicity and subsidence interpreted as a magma conduit, and (2) a more diffuse, 8-km radius zone of shallow seismicity (<2 km) above a shadow zone, interpreted as a magma chamber between 2.5 and 6 km subsurface. InSAR and continuous GPS data show uplift above a shallow source in zone (2) and uplift above the largely aseismic Gab'ho volcano. The patterns of seismicity provide a 3-D perspective of magma feeding systems maintaining the along-axis segmentation of this incipient seafloor spreading segment

Pathological findings associated with the updated European Society of Cardiology 2022 guidelines for preoperative cardiac testing: an observational cohort modelling study

Background: In 2022, the European Society of Cardiology updated guidelines for preoperative evaluation. The aims of this study were to quantify: (1) the impact of the updated recommendations on the yield of pathological findings compared with the previous guidelines published in 2014; (2) the impact of preoperative B-type natriuretic peptide (NT-proBNP) use for risk estimation on the yield of pathological findings; and (3) the association between 2022 guideline adherence and outcomes. Methods: This was a secondary analysis of MET-REPAIR, an international, prospective observational cohort study (NCT03016936). Primary endpoints were reduced ejection fraction (EF<40%), stress-induced ischaemia, and major adverse cardiovascular events (MACE). The explanatory variables were class of recommendations for transthoracic echocardiography (TTE), stress imaging, and guideline adherence. We conducted second-order Monte Carlo simulations and multivariable regression. Results: In total, 15,529 patients (39% female, median age 72 [inter-quartile range: 67–78] yr) were included. The 2022 update changed the recommendation for preoperative TTE in 39.7% patients, and for preoperative stress imaging in 12.9% patients. The update resulted in missing 1 EF <40% every 3 fewer conducted TTE, and in 4 additional stress imaging per 1 additionally detected ischaemia events. For cardiac stress testing, four more investigations were performed for every 1 additionally detected ischaemia episodes. Use of NT-proBNP did not improve the yield of pathological findings. Multivariable regression analysis failed to find an association between adherence to the updated guidelines and MACE. Conclusions: The 2022 update for preoperative cardiac testing resulted in a relevant increase in tests receiving a stronger recommendation. The updated recommendations for TTE did not improve the yield of pathological cardiac testing