Ektopik Gebelik Olgularında Methotrexatın Tedavi Etkinliğinin Değerlendirilmesi

Aim: Our aim in this study was to assess efficacy of singledose methotrexate (MTX) as medical treatment for ectopic pregnancy (EP) by evaluating the results of patients given this treatment. Materials and Methods: Between September 2016 and August 2017, the treatment outcomes of EP cases treated with MTX at Gazi Yaşargil Training and Research Hospital of Health Sciences University were evaluated retrospectively. Results: In total, 126 cases treated for EP were evaluated and 65 cases were included in the study. In cases administered a single dose of MTX, the success rate was 80%, the failure rate was 13.8%, and the emergency surgery rate was 6.2%. The overall success rate of the medical treatment was 90.7% for a second dose of MTX. An unsuccessful result was considered as less than a 15% reduction in the beta-human chorionic gonadotropin (?-hCG) level between 4 and 7 days after single dose MTX administration. In all cases, the rate of emergency surgery after treatment was 9.3%. Conclusions: In our study, success rates in patients with EP treated with MTX were 80% after a single dose and as high as 90.7% when a second dose was addedAmaç: Bu çalışmadaki amacımız ektopik gebelik’ te (EP) medikal tedavi olarak tek doz methotrexat (MTX) tedavisi verilen olguların sonuçlarının değerlendirilmesidir. Materyal ve Metot: Eylül 2016 ile Ağustos 2017 arasında Sağlık Bilimleri Üniversitesi Gazi Yaşargil Eğitim ve Araştırma Hastanesinde tedavi edilen EP olgularında MTX tedavisi uygulanmış olanların tedavi sonuçları retrospektif olarak değerlendirildi. Bulgular: Çalışmanın yapıldığı tarihler arasında EP nedeniyle tedavi edilen 126 olgu çalışmaya dahil edildi. Tek doz MTX tedavisi başlanan olgularda başarı oranı %80, başarısızlık %13.8 ve acil cerrahi oranı %6.2 olarak gerçekleşti. Tek doz MTX uygulaması sonrasında 4 ve 7 günler arsında betahuman chorionic gonadotropin (?-hCG) seviyesinin %15 ten az düşmesi sonucunda başarısız olarak kabul edilen olgularda yapılan 2. doz MTX sonucunda, medikal tedavinin toplam başarı oranı %90.7 olarak gerçekleşirken, bu olguların tümünde tedavi sonrası acil cerrahi oranı %9.3 olarak gerçekleşti. Sonuç: Çalışmamızda uygun endikasyonla MTX tedavisi uygulanan EP olgularında medikal tedavinin başarı oranı %90.7 gibi oldukça yüksek bir oranda gerçekleşmiş olup olguların sadece %9.3 de MTX tedavisi sonrasında acil cerrahi tedavi gerekmiştir

Assessment of Methotrexate Efficacy in The Treatment of Ectopic Pregnancy

Aim:Our aim in this study was to assess efficacy of single-dose methotrexate (MTX) as medical treatment for ectopic pregnancy (EP) by evaluating the results of patients given this treatment.Materials and Methods:Between September 2016 and August 2017, the treatment outcomes of EP cases treated with MTX at Gazi Yaşargil Training and Research Hospital of Health Sciences University were evaluated retrospectively.Results:In total, 126 cases treated for EP were evaluated and 65 cases were included in the study. In cases administered a single dose of MTX, the success rate was 80%, the failure rate was 13.8%, and the emergency surgery rate was 6.2%. The overall success rate of the medical treatment was 90.7% for a second dose of MTX. An unsuccessful result was considered as less than a 15% reduction in the beta-human chorionic gonadotropin (β-hCG) level between 4 and 7 days after single dose MTX administration. In all cases, the rate of emergency surgery after treatment was 9.3%.Conclusions:In our study, success rates in patients with EP treated with MTX were 80% after a single dose and as high as 90.7% when a second dose was added

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

Enhancing the robustness of functional biomacromolecules is a critical challenge in biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical processing and biostorage. Here we report a novel method, inspired by natural biomineralization processes, which provides unprecedented protection of biomacromolecules by encapsulating them within a class of porous materials termed metal-organic frameworks. We show that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules. The resulting biocomposite is stable under conditions that would normally decompose many biological macromolecules. For example, urease and horseradish peroxidase protected within a metal-organic framework shell are found to retain bioactivity after being treated at 80 °C and boiled in dimethylformamide (153 °C), respectively. This rapid, low-cost biomimetic mineralization process gives rise to new possibilities for the exploitation of biomacromolecules.Kang Liang, Raffaele Ricco, Cara M. Doherty, Mark J. Styles, Stephen Bell, Nigel Kirby, Stephen Mudie, David Haylock, Anita J. Hill, Christian J. Doonan, Paolo Falcar

Oscillation of impulsive linear differential equations with discontinuous solutions

http://dx.doi.org/10.1017/S000497271200033

Advanced Functional Polymers for Biomedical Applications: Drug, Sensor, Diagnosis, and Prognosis

Since the last decade, the use of functional polymers for diagnosis, prognosis, and treatment in medicine is developing rapidly. The functional polymers are synthesized in different geometrical shapes and dimensions for various purposes. Therefore, the polymers are designed in the use of drugs and gene delivery systems, sensor applications, diagnosis, and prognosis of various diseases. This chapter presents an overview of functional polymer classification and discusses the basic properties and potential applications in the biomedical area. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG

Preparation of molecular imprinted hydrophobic polymeric nanoparticles having structural memories for lysozyme recognition

PubMed ID: 22409278This study is related to the preparation of lysozyme-imprinted poly(hydroxyethyl methacrylate-N-methacryloyl-(L)-tyroptophan methylester) [nano-MIP] nanoparticles for purification of lysozyme. Nano-MIP particles were found to be 261 nm in diameter with a surface area of 1648 m/g. According to the elemental analysis results, the particles contained 0.85 µmol MATrp/g polymer. The maximum lysozyme adsorption capacity was 1182.8 mg2/g. Adsorbed lysozyme was desorbed with 94% recovery. It was observed that after five adsorption-desorption cycles there was no significant loss in adsorption capacity. In order to show the selectivity of the Lys-MIP nanoparticles, adsorption of lysozyme, bovine serum albumin (BSA), and cytochrome c were investigated. Copyright © 2012 Informa Healthcare USA, Inc

Nanobiosensors: Usability of Imprinted Nanopolymers

Since the past decade, the use of nanomaterials, especially nano-molecular imprinted (nano-MIP) systems, production and equipment integration are rapidly improving due to affinity sensors. This chapter focuses on the nanobiosensors usability of imprinted nanopolymers for various purposes. It is important to assess potential applications for several areas such as environmental, food safety, medicine, etc. In addition, latest trend is minimally invasive or non-invasive wearable and implantable biomedical applications for continuous and real-time monitored systems. This chapter presents an overview of nano-MIP sensors and classification of nanopolymers and discusses basic properties and potential applications. © 2021 Elsevier Inc

Sensor commercialization and global market

A sensor is an instrument that converts a physical, chemical, and/or biological stimulus into an electrical output via several transducer elements. Sensors are increasingly utilized in biomedical or environmental applications in the literature and industry. A life-cycle approach that includes several steps ranging from conception to commercialize to develop a sensor from idea to product is needed. In a sensor development concept, developers, and potential investors should be consider the market requirements, design possibilities, feasibility, financial return, and risk assessments. It is crucial to provide a well-defined regulatory pathway for bringing new innovation to the market with low cost and time. According to market research, microelectromechanical systems (MEMS) have a huge percentage of the market but nanoelectromechanical systems are expected to be the fastest growers, even if MEMS technology is the leader for now. Experts anticipate that the healthcare sensors will be a top growing field with the aid of artificial intelligence-based digital health applications. This chapter summarizes how to balance basic-science innovation with the reach commercialization and global market of sensors. © 2023 Elsevier Inc. All rights reserved