Vuelo del dragón: Transformar personas, organizaciones y marcas

Proyecto en el que se trabajó con la agencia de mercadotecnia Alquimia. El reto fue crear un nuevo modelo para diferenciar a esta empresa de la competencia. La metodología de innovación, que se centró en el ciclo de propuesta y validación continua con los beneficiarios finales, consistió en entrevistar a personas encargadas de contratar los servicios de mercadotecnia y comunicación que son parte de empresas que tienen grandes presupuestos para mercadotecnia y que son atractivas para Alquimia. Una vez identificada la necesidad a atender, se creó una solución, a la cual se le llamó Client Shadow o Sombra del Cliente. Este modelo de servicio busca conocer de cerca a la empresa cliente y a su producto. El modelo fue validado por la Asociación Mexicana de Agencias de Publicidad (AMAP) y por el departamento de mercadotecnia de Nike. Ambos coincidieron que esta solución puede ayudar a Alquimia a ganar ventaja competitiva y agregar valor a su modelo de negocio

Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease

Abstract: The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting early structural and functional traits associated with the disorder, we sought to characterize cortical thickness and subcortical grey matter volume, cerebral metabolism, and amyloid deposition in persons at risk for LOAD in comparison with a similar group without family history of AD. We obtained 3T T1 images for gray matter volume, FDG-PET to evaluate regional cerebral metabolism, and PET-PiB to detect fibrillar amyloid deposition in 30 middle-aged, asymptomatic, cognitively normal individuals with one parent diagnosed with LOAD (O-LOAD), and 25 comparable controls (CS) without family history of neurodegenerative disorders (CS). We observed isocortical thinning in AD-relevant areas including posterior cingulate, precuneus, and areas of the prefrontal and temporoparietal cortex in O-LOAD. Unexpectedly, this group displayed increased cerebral metabolism, in some cases overlapping with the areas of cortical thinning, and no differences in bilateral hippocampal volume and hippocampal metabolism. Given the importance of age in this sample of individuals potentially developing early AD-related changes, we controlled results for age and observed that most differences in cortical thickness and metabolism became nonsignificant; however, greater deposition of β-amyloid was observed in the right hemisphere including temporoparietal cortex, postcentral gyrus, fusiform inferior and middle temporal and lingual gyri. If replicated, the present observations of morphological, metabolic, and amyloid changes in cognitively normal persons with family history of LOAD may bear important implications for the definition of very early phenotypes of this disorder.Fil: Duarte-Abritta, Bárbara. Fundación FLENI. Servicio de Psiquiatría; ArgentinaFil: Villareal, Mirta F. Fundación FLENI. Servicio de Psiquiatría; ArgentinaFil: Villarealm, Mirta F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Abulafia, Carolina. Fundación FLENI. Servicio de Psiquiatría; ArgentinaFil: Abulafia, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Abulafia, Carolina. Universidad Católica Argentina. Facultad de Ciencas Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Loewenstein, David A. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados UnidosFil: Curiel-Cid, Rosie. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados UnidosFil: Castro, Mariana N. Fundación FLENI. Servicio de Psiquiatría; ArgentinaFil: Castro, Mariana N. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castro, Mariana N. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; ArgentinaFil: Surace, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Surace, Ezequiel. Fundacion FLENI. Departamento de Neuropatología y Biología Molecular; ArgentinaFil: Vigo, Daniel E. Consejo Nacional de Investigaciones Científicas y Tecnicas; ArgentinaFil: Vigo, Daniel E. Universidad Católica Argentina. Facultad de Ciencas Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Vázquez, Silvia. Fundación FLENI. Centro de Imágenes Moleculares; ArgentinaFil: Nemeroff, Charles B. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences; Estados UnidosFil: Sevlever, Gustavo. Fundacion FLENI. Departamento de Neuropatología y Biología Molecular; ArgentinaFil: Guinjoan, Salvador M. Fundación FLENI. Servicio de Psiquiatría; ArgentinaFil: Guinjoan, Salvador M. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de psiquiatría y salud mental; ArgentinaFil: Guinjoan, Salvador M. Universidad de Buenos Aires. Facultad de Psicología. Neurofisiología I; Argentin

Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease.

Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer's disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer's disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer's disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer's-relevant brain regions even at a relatively young age.status: publishe

Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease.

The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting early structural and functional traits associated with the disorder, we sought to characterize cortical thickness and subcortical grey matter volume, cerebral metabolism, and amyloid deposition in persons at risk for LOAD in comparison with a similar group without family history of AD. We obtained 3T T1 images for gray matter volume, FDG-PET to evaluate regional cerebral metabolism, and PET-PiB to detect fibrillar amyloid deposition in 30 middle-aged, asymptomatic, cognitively normal individuals with one parent diagnosed with LOAD (O-LOAD), and 25 comparable controls (CS) without family history of neurodegenerative disorders (CS). We observed isocortical thinning in AD-relevant areas including posterior cingulate, precuneus, and areas of the prefrontal and temporoparietal cortex in O-LOAD. Unexpectedly, this group displayed increased cerebral metabolism, in some cases overlapping with the areas of cortical thinning, and no differences in bilateral hippocampal volume and hippocampal metabolism. Given the importance of age in this sample of individuals potentially developing early AD-related changes, we controlled results for age and observed that most differences in cortical thickness and metabolism became nonsignificant; however, greater deposition of β-amyloid was observed in the right hemisphere including temporoparietal cortex, postcentral gyrus, fusiform inferior and middle temporal and lingual gyri. If replicated, the present observations of morphological, metabolic, and amyloid changes in cognitively normal persons with family history of LOAD may bear important implications for the definition of very early phenotypes of this disorder.status: publishe

Pulmonary imaging in coronavirus disease 2019 (COVID-19): a series of 140 Latin American children.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which resulted in the worldwide coronavirus disease 2019 (COVID-19) pandemic of 2020, has particularly affected Latin America. The purpose of the study was to analyze the imaging findings of pulmonary COVID-19 in a large pediatric series. Children with SARS-CoV-2 infection confirmed by either quantitative reverse transcription-polymerase chain reaction from nasopharyngeal swabs or presence of circulating immunoglobulin M (IgM) antibodies and who underwent chest radiograph or CT or both were included in this retrospective multicenter study. Three pediatric radiologists independently reviewed radiographs and CTs to identify the presence, localization, distribution and extension of pulmonary lesions. We included 140 children (71 female; median age 6.3 years, interquartile range 1.6-12.1 years) in the study. Peribronchial thickening (93%), ground-glass opacities (79%) and vascular engorgement (63%) were the most frequent findings on 131 radiographs. Ground-glass opacities (91%), vascular engorgement (84%) and peribronchial thickening (72%) were the most frequent findings on 32 CTs. Peribronchial thickening (100%), ground-glass opacities (83%) and pulmonary vascular engorgement (79%) were common radiograph findings in asymptomatic children (n=25). Ground-glass opacity and consolidation were significantly higher in children who needed intensive care admission or died (92% and 48%), in contrast with children with a favorable outcome (71% and 24%, respectively; P Asymptomatic children and those with mild symptoms of COVID-19 showed mainly peribronchial thickening, ground-glass opacities and pulmonary vascular engorgement on radiographs. Ground-glass opacity and consolidation were more common in children who required intensive care admission or died