Study of Diluted Meldonium Solutions by Surface Enhanced Raman Scattering Spectroscopy

Silvered porous silicon was utilized as an active substrate for a detection of small amounts of meldonium by surface enhanced Raman scattering (SERS) spectroscopy. We were able to detect the meldonium in its water solutions at the concentrations of 102–106 M. Immersion of the silvered porous silicon in the meldonium solutions at the 104M concentration and lower led to the dimers' formation. At the concentrations larger than 103 M, a greater contribution to the enhancement of the Raman intensity was caused by a chemical mechanism while the smaller amounts were detected mostly due to an electromagnetic mechanism