Use of ordination and classification procedures to evaluate phytoplankton communities during Superflux II

Cluster analysis and an ordination procedure were performed on two data matrices to investigate real and environmental spatial relationships. Multiple regression analysis was used to relate the measured environmental variables to the phytoplankton community changes. Qualitative type phytoplankton data proved to be less structured in both of these spaces, relative to the biomass data. The salinity gradients of the northern transects covaried significantly with the phytoplankton association changes. In the southern transects the light variable was most important in explaining the variance in the ordination axes. These data suggest the close relationships between phytoplankton community changes and the physical hydrology of the area

A systems biology analysis of brain microvascular endothelial cell lipotoxicity.

BackgroundNeurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimer's disease, which are increasingly important causes of morbidity and mortality around the world. Lipotoxicity is a metabolic disorder that results from accumulation of lipids, particularly fatty acids, in non-adipose tissue leading to cellular dysfunction, lipid droplet formation, and cell death.ResultsOur studies indicate for the first time that the neurovascular circulation also can manifest lipotoxicity, which could have major effects on cognitive function. The penetration of integrative systems biology approaches is limited in this area of research, which reduces our capacity to gain an objective insight into the signal transduction and regulation dynamics at a systems level. To address this question, we treated human microvascular endothelial cells with triglyceride-rich lipoprotein (TGRL) lipolysis products and then we used genome-wide transcriptional profiling to obtain transcript abundances over four conditions. We then identified regulatory genes and their targets that have been differentially expressed through analysis of the datasets with various statistical methods. We created a functional gene network by exploiting co-expression observations through a guilt-by-association assumption. Concomitantly, we used various network inference algorithms to identify putative regulatory interactions and we integrated all predictions to construct a consensus gene regulatory network that is TGRL lipolysis product specific.ConclusionSystem biology analysis has led to the validation of putative lipid-related targets and the discovery of several genes that may be implicated in lipotoxic-related brain microvascular endothelial cell responses. Here, we report that activating transcription factors 3 (ATF3) is a principal regulator of TGRL lipolysis products-induced gene expression in human brain microvascular endothelial cell

The Concordiensis, Volume 27, Number 7

Advertisements; Middlebury 0-Union 0; Football Games; Vesper Service; College Meeting; Psi Upsilon Dance; Fraternity Initiates; Medic Notes; Traditions of the Football Field; Dictes and Sayings; Erochs of Modern History; The Undivine Comedy ; The Wind; Love\u27s Language; Alumni; Intercollegiate; Eli Lectures; An Erudite Prisoner; Advertisementshttps://digitalworks.union.edu/concordiensis_1903/1023/thumbnail.jp

The Concordiensis, Volume 27, Number 11

Advertisements; The Captain\u27s Christmas; Alumni Banquet; The Press Club; College Notes; Smiles of the Campus; Dictes and Sayings; A Song of Home; The Little Breeze; The Unreached; Phi Gamma Delta Dance; Intercollegiate; To Meet the Football Team; Choosing the All-America Team; Alumni; Journalism as She is Writ; Sadie Holds Her Age Well; All Lovely in Breathitt; Oregon Society Note; Oppose Short College Course; Advertisementshttps://digitalworks.union.edu/concordiensis_1903/1027/thumbnail.jp

The Concordiensis, Volume 27, Number 6

Advertisements; Union 12-R.P.I. 11; Football Games; Reminiscences of a Trip Through Holland; Vesper Service; Medic Notes; Junior Hop; A Letter from Eli; Dictes and Sayings; Football a Century Ago; Sonnet. To One Sleep; Sacrifice; Alumni; Inter-Collegiate; The Original Cane Rush; Less Study Abroad; Value of Language Study; Advertisementshttps://digitalworks.union.edu/concordiensis_1903/1022/thumbnail.jp

Public Range Lands in Grazing Districts

When the editor of the Ames Forester so graciously asked me for an article on the Taylor Grazing Act and its operation in the West, I saw a chance to render a small service to the great agricultural State of Iowa. If a better understanding of the tie between an agricultural economy and the western range economy may be had, that service may be worth while

The Concordiensis, Volume 27, Number 3

Advertisements; Mr. Mabie\u27s Lecture; Vesper Service; Alumni; As to College Snobbishness; College Meeting; Senior Class Committees; An Autumn Plaint; Sonnet; The Storm; So Young and Fair; Man\u27s Greatness; An Ode to Tennis; The Football Man; Dictes and Sayings; Delta Upsilons Entertain; Campus Notes; The Value of Good English; Eli Got There; Remarkable Engineering Feat; Advertisementshttps://digitalworks.union.edu/concordiensis_1903/1019/thumbnail.jp

The Concordiensis, Volume 27, Number 8

Advertisements; Union University; Rochester 17- Union 6; Football Games; Campus Notes; Alumni; Pyramid Club Banquet; Dictes and Sayings; The Unreturning Tide; Dual Morality; Christ the Human; Kappa Alpha Entertains; A Press Club Organized; Delta U Conventions; Inter-Collegiate; Town Nomenclature; What Literature Owes to Walkers; Taken from the Enemy ; Advertisementshttps://digitalworks.union.edu/concordiensis_1903/1024/thumbnail.jp

The Concordiensis, Volume 27, Number 1

Advertisements; The Football Season; The Cane Rush; A Good Kick-Off; Amherst-Union Chess Tournament; Mr. Thayer\u27s Lecture; Vesper Service; College Meeting; The Class of 1907; To a Rose; Dictes and Sayings; The Constitutional Amendment; Campus Notes; Alumni Notes; The Music of the Pines; Night; Brevities of Science; Chinese Proverbs; Advertisementshttps://digitalworks.union.edu/concordiensis_1903/1017/thumbnail.jp