On the area of optimal parameters choice for the numerical method of non-stationary hydrodynamics problem with feature

For an approximate solution of the non-stationary nonlinear Navier-Stokes equations for the flow of an incompressible viscous fluid, depending on the set of input data and the geometry of the domain, the area of optimal parameters in the variables $\nu$ and $\nu^{\ast}$ is experimentally determined depending on $\delta$ included in the definition of the $R_{\nu}$-generalized solution of the problem and the degree of the weight function in the basis of the finite element method. To discretize the problem in time, the Runge-Kutta methods of the first and second orders were used. The areas of optimal parameters for various values of the incoming angles are established.Comment: 7 pages, 3 figure

Oil and Gas Exploration Planning using VOI Technique

Paper deals with actual problem about making decisions during field development. The main aim was to apply method "Value of information" in order to estimate the necessity of field exploration works and show the effectiveness of this method. The object of analysis - field X, which is located in the Eastern Siberia. The reservoir is B13 formation of Vend age. The Field has complex structure, and divided into blocks by faults. During evaluation of the project, main uncertainties and oil in place were obtained for three blocks of the field. According to uncertainty analysis, it was suggested to drill a new exploration well, and value of information method was applied to estimate results from this exploration works. Economic evaluation of the value of information method was made by choosing optimal development strategy. According to the obtained results, drilling of the exploration wells for blocks 1 and 3 of the field X is a good decision, while drilling a well in the second block is risky and not recommended. Also using the value of information, optimal well locations were advised - well l_le for the first block, and well 3_3 for the third block

Oil and Gas Exploration Planning using VOI Technique

Paper deals with actual problem about making decisions during field development. The main aim was to apply method "Value of information" in order to estimate the necessity of field exploration works and show the effectiveness of this method. The object of analysis - field X, which is located in the Eastern Siberia. The reservoir is B13 formation of Vend age. The Field has complex structure, and divided into blocks by faults. During evaluation of the project, main uncertainties and oil in place were obtained for three blocks of the field. According to uncertainty analysis, it was suggested to drill a new exploration well, and value of information method was applied to estimate results from this exploration works. Economic evaluation of the value of information method was made by choosing optimal development strategy. According to the obtained results, drilling of the exploration wells for blocks 1 and 3 of the field X is a good decision, while drilling a well in the second block is risky and not recommended. Also using the value of information, optimal well locations were advised - well l_le for the first block, and well 3_3 for the third block

Criteria for the development of social responsibility in future officers of the national guard of the Russian Federation

This article examines the key problem of the modern educational paradigm the problem of personal development. The author highlights several contradictions in this problem, one of which is the definition of development criteria. According to the author, the fundamental quality of a person is its social responsibility. The problem of social responsibility in society is now recognized by many as a potential danger to humanity, which is confirmed by the activity in the framework of research in this area. Therefore, the concept of social responsibility of the individual as a phenomenon in science has developed quite steadily. A serious problem of social responsibility is in the sphere of professional activity. You can often hear the following concepts: social responsibility of a doctor, social responsibility of a teacher, social responsibility of a scientist, social responsibility of a business, etc. However, the current socio-political situation forces us to talk about the social responsibility of the military. The analysis of scientific research shows that social responsibility is poorly developed among military personnel. The specifics of military professional activity of a serviceman require the development of their own criteria for evaluating its development. The analysis of the military professional activity of the future officer indicates the need to consider social responsibility in this category of persons from the position of its three criteria: attitude to activity, attitude to other people, attitude to oneself. This hypothesis was tested and proved as a result of the research. The study was conducted in three stages. At the first stage, a number of personal characteristics were identified that relate to the social responsibility of the individual. At the second stage, an expert survey was conducted to determine the level of manifestation of signs of social responsibility in a group of cadets with a high level of social responsibility. The final step was the factor analysis procedure, the results of which established that a high level of social responsibility of personality of future officer equally determine all three of its criteria: attitude to activity, attitude to other people, attitude to oneself

Calculation of characteristics of hydrodynamical bearing with defined profile of sleeves based on Mathcad

Стаття присвячена проблемам моделювання роботи гідродинамічних опор ковзання в умовах рідинного тертя. Метою роботи є створення автоматизованої системи розрахунку характеристик опор ковзання з втулками довільного (гладкого) профілю. З цією метою розроблені методика і алгоритм вирішення задачі визначення несучої здатності опори ковзання з заданим профілем втулки, а також розроблені рекомендації з отримання раціональних профілів втулок підшипників ковзання. На базі даної методики розроблено систему розрахунку характеристик підшипника ковзання з застосуванням пакета комп'ютерної алгебри Mathcad. Розроблена розрахункова система була використана для пошуку варіантів раціонального профілювання втулки опори ковзання. Були знайдені варіанти профілю втулок опор ковзання, що забезпечують збільшення несучої здатності в порівнянні з опорами, в яких застосовується традиційний (круглий) профіль втулки. Також розроблена система дозволяє проводити експрес-порівняння характеристик опор ковзання з різними профілями втулки.The article is devoted to problems of hydrodynamic simulations of sliding friction in the liquid. The aim is to create an automated system for calculating the characteristics of sliding sleeves with arbitrary (smooth) profile. For this purpose developed a technique and algorithm for determining the carrying capacity of the bearing with arbitrary profile of the sliding sleeve, and developed recommendations for obtaining rational profiles of sleeve of bearing. On the basis of this methodology developed a system for calculating the characteristics of sliding bearing with the use of package of computer algebra Mathcad. Developed calculation system was used to search for variants of rational profiling of sleeve of sliding bearings. Were found variants of profile of sliding sleeves that provide an increase in carrying capacity compared with the supports that use traditional (round) profile of the sleeve. Designed system also allows quick comparison of the characteristics of sliding sleeves with different profiles.Статья посвящена проблемам моделирования работы гидродинамических опор скольжения в условиях жидкостного трения. Целью работы является создание автоматизированной системы расчета характеристик опор скольжения с втулками произвольного (гладкого) профиля. С этой целью разработаны методика и алгоритм решения задачи определения несущей способности опоры скольжения с задаваемым профилем втулки, а также разработаны рекомендации по получению рациональных профилей втулок подшипников скольжения. На базе данной методики разработана система расчета характеристик подшипника скольжения с применением пакета компьютерной алгебры Mathcad. Разработанная расчетная система была использована для поиска вариантов рационального профилирования втулки опоры скольжения. Были найдены варианты профиля втулок опор скольжения, обеспечивающие увеличение несущей способности по сравнению с опорами, в которых применяется традиционный (круглый) профиль втулки. Также разработанная система позволяет проводить экспресс-сравнение характеристик опор скольжения с различными профилями втулки

Serum Interleukin-6 in Schizophrenia: Associations with Clinical and Sociodemographic Characteristics

BACKGROUND:Recentlyasignificant part of schizophrenia studies have been focused on the role of cytokines, especially interleukin-6 (IL-6). Some authors have suggestedapathogenetic role for IL-6 in schizophrenia and concluded that therapy that centers on suppressing IL-6 activity may prove beneficial for certain categories of patients with the disorder. However, many questions about whether the changes in IL-6 levels in schizophrenia are primary, related to symptoms or caused by therapy, are concomitant metabolic disorders, are related to smoking or other secondary factors remain unanswered. AIM:To assess the level of serum IL-6 in patients with schizophrenia in comparison with healthy controls, as well as to study its association with clinical and socio-demographic characteristics. METHODS:Some 125 patients with schizophrenia and 95 healthy volunteers were examined.Theevaluation of IL-6 was performed by enzyme immunoassay. All patients were assessed using standardized psychometric instruments. Information from patient medical records on the course of the disease and treatment wasanalyzed. RESULTS:Thelevel of IL-6 was significantly higher in the patients than in the healthy volunteers (z=2.58;p=0.0099), but among men the difference between the patients and volunteers was not significant. Statistically significant correlations were found between the level of serum IL-6 and the severity of the cognitive impairment of patients: (auditory [ρ=–0.31;p=0.00063] and working memory [ρ=−0.25;p=0.0065], hand-eye coordination [ρ=−0.29;p=0.0011], verbal fluency [ρ=−0.28;p=0.0019] and problem-solving capacity [ρ=−0.22;p=0.013]), total severity of schizophrenia symptoms (PANSS, ρ=0.22;p=0.016), PANSS positive subscale (ρ=0.18;p=0.048), and the age of manifestation (ρ=0.20;p=0.025) and disease duration (ρ=0.18;p=0.043).Thelevel of IL-6 was the lowest in patients treated with third-generation antipsychotics, and the highest in those treated withfirst-generation antipsychotics (H=6.36;p=0.042). Moreover, in hospital patients, the level of IL-6 was significantly higher than in outpatients and inpatients hospitals (H=18.59;p=0.0001). CONCLUSION:Thestudy confirmed that there are associations between the serum IL-6 level and schizophrenia, the age of the patient, duration of the disease and how late in one's life cycle it began manifesting itself, as well asanumber of clinical characteristics. Considering that IL-6isassociated withawide range of symptoms that are loosely controlled by antipsychotics, this biochemical marker needs to be studied to look into how closely its level tracks with an unfavorable course of schizophrenia. That would require further prospective studies

Gastrointestinal stromal tumors in elderly patients

To study the age-related characteristics of GISTs development in patients of older age group

Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan

Introduction. Due to their high biocompatibility, substances based on nanosized selenium particles, encapsulated in natural or synthetic polymer matrices, are promising materials for the creation of biomedical preparations of diagnostic and therapeutic value. Selenium nanoparticles are successfully used in the diagnosis of various types of cancer. In addition to the diagnostic value, selenium nanoparticles have their own prophylactic and oncological effect. This paper presents the results of a study of the toxicity of the Se nanocomposite encapsulated in the polymer matrix of arabinogalactan (SeAG). The emergence and development of the pathological process in the tissue of the brain, liver and kidneys during subacute administration of this nanocomposite was studied.Materials and methods. Twenty white outbred male rats weighing 200–220 g were used in the work. Animals were orally administered a solution of the selenium nanocomposite at a dose of 500 μg per kilogram of animal body weight for 10 days. Then, using the methods of histological analysis, the severity of the biological response of the organism to the introduction of this nanocomposite was assessed. An analysis of the state of the tissue of the liver, kidneys and the sensorimotor cortex of the brain was carried out.Results. With the intragastric administration of this drug, there is stasis of blood in the portal tracts, a pronounced macrophage reaction and diapedesis of leukocytes in the liver tissue. There is a decrease in the number of normal neurons per unit area, a decrease in the number of astroglia cells and an increase in the number of  degeneratively altered neurons in the tissue of the sensorimotor cortex. There is also an increase in connective tissue in the cortex of the kidney, with the formation of fibrosis and a decrease in the area of the Shumlyansky – Bowman capsule.Conclusion. The effect of the investigated nanocomposite is characterized by the development of a pronounced pathological process in the central nervous and hepatorenal systems of the body

From experimental biomodeling to personalized medicine

This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats. The results of this study show that newborn offspring of rats exposed to vinyl chloride and mercuric chloride lagged behind the controls in sensory-motor development. There was violated the whole structure of behavior in adult offspring characterized by reduces motor and exploratory activity, increased anxiety in rats. There was abnormal impulse conduction in the neuromuscular apparatus of the hind legs of albino rats and morphological changes in the structure of nervous tissue. Developmental disorders in the offspring may be associated with the processes of accumulation, influence on the genetic apparatus of cells or mediated by epigenetic mechanisms of CNS disorders. A comparative study of the behavioral and cognitive effects of toluene, cerebral bioelectrical activity in rats with a normal embryogenesis and background prenatal hypoxia has been found that toluene neurotoxicity are more pronounced in adult rats exposed to chronic prenatal hypoxia. The results suggest a possible decrease in the sensitivity of neurons to the action of neurotoxicants because of prenatal hypoxic damage. The significance of experimental modeling is to develop approaches to personalized medicine, because knowledge of the previous prenatal pathology or neurointoxication of parents allow study of individual measures of prevention, treatment, and decisions about employment of the younger generation