Europe 2020 strategy: a strategy for which type of growth?

This paper constructs an index that synthesizes the eight targets of the EU 2020 Strategy into a one-dimensional target –EU 2020 synthetic target- and the situation of each EU28 Member States (the current 27 Members plus Croatia) in 2011 with respect to them –2011 synthetic situation-. Hence we can measure the distance of each EU Member State synthetic situation in 2011 to the EU 2020 synthetic target. We find that none of the Member States meets the EU 2020 synthetic target, Denmark is the closest and Malta is the furthest to it. In fact we could identify clusters of Member States in terms of the distances to the EU 2020 synthetic target: the North EU region is closer to and the Mediterranean region is further away from it. We extent the distance analysis above by adding three inequality targets -income distribution, female employment and child poverty- and find that all of the Member States increase their distance between their 2011 synthetic inequality-extended situation and the 2020 inequality-extended targeted situation. Finally, we want to analyse each Member State’s relationship between its objective position regarding the EU 2020 synthetic target and its life satisfaction level, inhabitants’ subjective position. Through a multivariate regression methodology, we analyse how much of the total effect of the synthetic index on life satisfaction is direct, and how much is mediated. The mediation analysis shows that a substantial part of the effect of the synthetic index on life satisfaction is mediated by the GDP per capita. These results are in line with recent views in human development and well-being research. That is, the GDP per capita is only a means to achieve socioeconomic progress, not the end

A Progressive Approach to the Measurement of Regional Performance in the European Union

The shared file includes (starting on page 6) the full text that we presented at the Progressive Economy Forum 2014, held at the European Parliament, Brussels 5-6 March 2014. Our work won the award for best paper in the area "Rethinking Economy Policy" and a summary of our presentation was published in the Journal for a Progressive Economy, 3, 62-64 (first pages of this file).El archivo compartido incluye (a partir de la página 6) el texto completo que presentamos en el Foro de Economía Progresista 2014, celebrado en el Parlamento Europeo, Bruselas, 5 y 6 de marzo de 2014. Nuestro trabajo ganó el premio al mejor artículo en el área "Rethinking Economy Policy" y un resumen de nuestra presentación fue publicada en el Journal for a Progressive Economy, 3, 62-64 (primeras páginas de este archivo).With a view to promote the European Union (EU) overall harmonious development, the EU Regional Policy –or Cohesion Policy- focuses on reducing disparities between the levels of development of the various regions and the backwardness of the least favoured regions. Structural Funds, the main instrument to achieve the EU Regional Policy objectives, are allocated by regional Gross Domestic Product (GDP) per capita. Furthermore, in the EU context, the socio-economic inequalities between both people and regions have been rising in the majority of Member States over the last three decades and are now higher than in 1980 regardless of consistent objectives for economic and social cohesion (Eurostat). This separation between economy and society could be potentially overcome by including a measure of social well-being in models of regional performance. However, and despite economic and social cohesion being core EU objectives since its foundation, the community regional performance is defined in a strict economic sense by the size and growth of the economy. Regions whose per capita income falls short off the threshold of the 75% of the EU average GDP per capita are less developed regions, and are thus eligible for Structural Funds support. The aim of this paper is to present a multidimensional approach to the measurement of regional performance as an alternative to a single criterion approach based on the GDP per capita. With this in mind: 1st. Drawing on the capabilities approach and the recent trends in well-being (i.e. Stiglitz-Sen-Fitoussi Report of 2009), we discuss the reasons that justify the revision of the current allocation mechanism of EU Structural Funds. 2nd. We develop a composite index to measure regional performance in the 269 regions of EU28 in 2009 from a multidimensional perspective (16 indicators of health, education, employment, inequalities, poverty, etc.) following two distinct multivariate methods (Principal Component Analysis and Distance P2). 3rd. We discuss some regional policy implications of a change in the rules. That is, we analyse the consequences of applying a multidimensional approach instead of the traditional GDP based allocation mechanism. We find that, with an equivalent budgetary effort regarding the population benefited from these funds, a distinct map of priority regions results. Based upon the indicators considered, Stockholm in Sweden is the most developed region with a development level that triples that achieved by the least developed region (Severozapaden in Bulgaria). Hence large territorial disparities exist. Employment (female and male) related aspects and GDP per capita adjusted by inequality are the key determining factors of regional development. Were the Structural Funds allocated by our regional development index instead of the GDP per capita, some regions of Belgium, France, Greece, Germany, Italy and Spain would be considered priority regions; whereas some other regions, mainly from Eastern Europe, would not be considered so

Review of Some Statistical Methods for Constructing Composite Indicators.

The methodology for the construction process of composite indicators is reviewed in a step-by-step approach ranging from the ex-ante definition of the latent variable that is intended to be measure, through the construction process of the composite indicators. We focus particularly on four aggregations methods in order analayze weighting and aggregation approach, Distance P_2, Principal Component Analysis, Data Envelopment Analysis and Mazziotta-Pareto Index. An empirical comparison among them is provided and the composite indices divergences are shown

Implementación de un procesador académico simple así como de un entorno de programación y depuración para el mismo

En este trabajo se desarrolla un procesador académico para su uso en la asignatura Estructura de Computadores de primer curso de las nuevas titulaciones de Grado en Ingeniería Informática. En las prácticas de la asignatura se aplicarán los conceptos de sistemas digitales que ya poseen los alumnos al diseño e implementación de este procesador con el objetivo de que interactúen con una instancia real del mismo desde distintos puntos de vista: modificándola para aumentar su funcionalidad, programándola para comprobar su funcionamiento y analizando su estado interno a medida que ejecuta instrucciones. La posibilidad de que el alumno traslade el diseño teórico a una implementación funcional es fundamental para incrementar su motivación en el aprendizaje.Ministerio de Ciencia e Innovación TEC2011-27936 (HIPERSYS

A Functional Pipeline of Genome-Wide Association Data Leads to Midostaurin as a Repurposed Drug for Alzheimer’s Disease

Genome-wide association studies (GWAS) constitute a powerful tool to identify the different biochemical pathways associated with disease. This knowledge can be used to prioritize drugs targeting these routes, paving the road to clinical application. Here, we describe DAGGER (Drug Repositioning by Analysis of GWAS and Gene Expression in R), a straightforward pipeline to find currently approved drugs with repurposing potential. As a proof of concept, we analyzed a meta-GWAS of 1.6 × 107 single-nucleotide polymorphisms performed on Alzheimer’s disease (AD). Our pipeline uses the Genotype-Tissue Expression (GTEx) and Drug Gene Interaction (DGI) databases for a rational prioritization of 22 druggable targets. Next, we performed a two-stage in vivo functional assay. We used a C. elegans humanized model over-expressing the Aβ1-42 peptide. We assayed the five top-scoring candidate drugs, finding midostaurin, a multitarget protein kinase inhibitor, to be a protective drug. Next, 3xTg AD transgenic mice were used for a final evaluation of midostaurin’s effect. Behavioral testing after three weeks of 20 mg/kg intraperitoneal treatment revealed a significant improvement in behavior, including locomotion, anxiety-like behavior, and new-place recognition. Altogether, we consider that our pipeline might be a useful tool for drug repurposing in complex diseases.This work was mainly financed by Programa Operativo FEDER funds from the European Union through grant UMA20-FEDERJA-133. We thank Fundacion SantÁngela for co-funding with grant 83/23.04.2021. P.G.-G. is supported by the CIBERNED employment plan CNV-304-PRF-866. CIBERNED is integrated into Instituto de Salud Carlos III. I.d.R is supported by a national grant from the Instituto de Salud Carlos III FI20/00215. A.R. is supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240, and PI19/01301. A.M.B.-L. and M.J.M. were funded by grant PID2020-120463RB-I00 funded by the Spanish Ministerio de Ciencia e Innovación. A.C.-Z. holds a postdoctoral research contract from Secretaría General de Universidades, Investigación y Tecnología–Junta de Andalucía (POSTDOC21_00365). B.P.S (IFI21/00024) holds an “iPFIS” predoctoral contract from the National System of Health, EU-ERDF-ISCIII. M.d.C.M.-P. holds predoctoral grants from the Spanish Ministry of Science, Innovation and Universities (FPU17/00276). P.R. (CP19/00068) holds a “Miguel Servet” research contract from the National System of Health, ISCIII co-funded by the European Social Fund, “Investing in your future,” Gobierno de España. This research was funded by Delegación del Gobierno para el Plan Nacional sobre Drogas, Ministerio de Salud, Gobierno de España (PND2020/048). Ethovision XT software v17 (Noldus, Wageningen, The Netherlands) funded by Plan Propio, Universidad de Málaga

Correcting non cephalic presentation with moxibustion: study protocol for a multi-centre randomised controlled trial in general practice

<p>Abstract</p> <p>Background</p> <p>Non cephalic presentation in childbirth involves various risks to both the mother and the foetus. The incidence in Spain is 3.8% of all full-term pregnancies. The most common technique used to end the gestation in cases of non cephalic presentation is that of caesarian section, and although it provokes a lower rate of morbi-mortality than does vaginal delivery in such situations, there remains the possibility of traumatic injury to the foetal head and neck, while maternal morbidity is also increased. The application of heat (moxibustion) to an acupuncture point, in order to correct non cephalic presentation, has been practised in China since ancient times, but as yet there is insufficient evidence of its real effectiveness.</p> <p>Methods/Design</p> <p>The experimental design consists of a multi-centre randomised controlled trial with three parallel arms, used to compare real moxibustion, sham moxibustion and the natural course of events, among pregnant women with a non cephalic presentation and a gestational duration of 33–35 weeks (estimated by echography). The participants in the trial will be blinded to both interventions. The results obtained will be analyzed by professionals, blinded with respect to the allocation to the different types of intervention. In addition, we intend to carry out a economic analysis.</p> <p>Discussion</p> <p>This trial will contribute to the development of evidence concerning moxibustion in the correction of non cephalic presentations. The primary outcome variable is the proportion of cephalic presentations at term. As secondary outcomes, we will evaluate the proportion of cephalic presentations at week 38 of gestation, determined by echography, together with the safety of the technique, the specificity of moxibustion and the control of the blinding process.</p> <p>This study has been funded by the Health Ministry of the Andalusian Regional Government.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN10634508.</p

Land- and water-based exercise intervention in women with fibromyalgia: the al-andalus physical activity randomised controlled trial

Background The al-Andalus physical activity intervention study is a randomised control trial to investigate the effectiveness of a land- and water-based exercise intervention for reducing the overall impact of fibromyalgia (primary outcome), and for improving tenderness and pain-related measures, body composition, functional capacity, physical activity and sedentary behaviour, fatigue, sleep quality, health-related quality of life, and cognitive function (secondary outcomes) in women with fibromyalgia. Methods/Design One hundred eighty women with fibromyalgia (age range: 35-65 years) will be recruited from local associations of fibromyalgia patients in Andalucía (Southern Spain). Patients will be randomly assigned to a usual care (control) group (n = 60), a water-based exercise intervention group (n = 60) or a land-based exercise intervention group (n = 60). Participants in the usual care group will receive general physical activity guidelines and participants allocated in the intervention groups will attend three non-consecutive training sessions (60 min each) per week during 24 weeks. Both exercise interventions will consist of aerobic, muscular strength and flexibility exercises. We will also study the effect of a detraining period (i.e., 12 weeks with no exercise intervention) on the studied variables. Discussion Our study attempts to reduce the impact of fibromyalgia and improve patients' health status by implementing two types of exercise interventions. Results from this study will help to assess the efficacy of exercise interventions for the treatment of fibromyalgia. If the interventions would be effective, this study will provide low-cost and feasible alternatives for health professionals in the management of fibromyalgia. Results from the al-Andalus physical activity intervention will help to better understand the potential of regular physical activity for improving the well-being of women with fibromyalgia.This study was supported by the Consejeria de Turismo, Comercio y Deporte (CTCD-201000019242-TRA), the Spanish Ministry of Science and Innovation (I + D + I DEP2010-15639, grants: BES-2009-013442, BES-2011-047133, RYC-2010-05957, RYC-2011-09011), the Swedish Heart-Lung Foundation (20090635), the Spanish Ministry of Education (AP-2009-3173), Granada Research of Excelence Initiative on Biohealth (GREIB), Campus BioTic, University of Granada, Spain and European University of Madrid. Escuela de Estudios Universitarios Real Madrid. 2010/04RM

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions