16 research outputs found

    Abbau von Reisstroh durch Pilzgemeinschaften aus Paddy Soils

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    Pilze haben in Reisböden (Paddy Soils) einen entscheidenden Einfluss auf den Ab-bau von Reisstroh. Allerdings unterliegt ihre Aktivität direkt den wechselnden Bewirt-schaftungszuständen des Nassfeldanbaus von Reis. In dieser Arbeit wurden Pilzisolate aus unter-schiedlichen Paddy Soils hinsichtlich ihres Abbaupotentials untersucht. In einem Inku-bationsversuch (20 Wochen) zeigten die aus-gewählten Isolate unterschiedliche Besied-lungsstrategien und Aktivitäten bei der Zer-setzung von Reisstroh

    Characterization of

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    ABSTRACT Neuropeptide Y (NPY) is a 36-amino acid peptide discovered in the early 1980s that belongs to a family of peptides that includes pancreatic polypeptides (PP) and peptide YY (PYY) The use of various cloning techniques has resulted in the identification of five receptors to date (Y 1 , Y 2 , Y 4 , Y 5 , and y 6

    dealii/candi: 9.2.0-r2

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    candi - (Compile & Install) - Downloads, configures, builds and installs deal.I

    The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor

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    A series of small molecules based on a chemotype identified from our compound collection were synthesized and tested for binding affinity (IC50) at the human Neuropeptide Y Y2 receptor (NPY Y2). Six of the 23 analogs tested possessed an NPY Y2 IC50 ⩽ 15 nM. One member of this series, JNJ 31020028, is a selective, high affinity, receptor antagonist existing as a racemic mixture. As such a synthetic route to the desired enantiomer was designed starting from commercially available (S)-(+)-mandelic acid
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