Chiral Anomaly and γ3π\gamma 3\pi

Measurement of the $\gamma 3\pi$ process has revealed a possible conflict with what should be a solid prediction generated by the chiral anomaly. We show that inclusion of appropirate energy-momentum dependence in the matrix element reduces the discrepancy.Comment: 8 page standard Latex fil

An interface for the interactive design of artistic screens

The article presents the concepts and the tools involved in the interactive design of artistic screens. The screen elements are derived from a small set of analytical contours provided by the screen designer. We present the requirements that these contours must satisfy in order to generate consistent screens. Software tools have been developed which provide automatic means for verifying and enforcing these constraints. They include a way of specifying the periodicity of the screen dot and a graphical interface offering a convenient way of specifying and tuning the growth of the screen do

Amount of Antiprotons in Cosmic Rays due to Halo Neutralino Annihilation

We evaluate the antiproton--to--proton flux ratio which can be generated by neutralino--neutralino annihilation in the galactic halo, considering the most general compositions for the relic neutralinos and modelling the neutralino local density according to its relic abundance. We find that in the case of mixed neutralino compositions this $\bar p/p$ ratio is higher than for pure higgsinos or gauginos. It is shown how the expected improvements in sensitivity for the new measurements of the $\bar p/p$ may provide very useful information, complementary to the one obtainable with other experimental means.Comment: 13 pages in Plain TeX, 7 figures included in a separate uuencoded tarred-compressed Postscript file; To appear in Astroparticle Physics; Report number: DFTT 35/9

Specifying color differences in a linear color space (LEF)

This work presents a novel way of generating color differences for synthesizing artistically screened color images. A single color is specified by interacting with the mouse alternately on a constant luminance plane and on a constant hue plane within the LEF color space (the orthogonal space formed by the RGB cube's black-white axis (L) and by its E and F chrominance axes). By interactively selecting a second color point, a color difference is specified. We present a method for extrapolating this color difference throughout all colors of the RGB cube so as to generate consistent color differences, i.e. smoothly varying similar color differences for different colors. The produced artistically screened color patches show that significant luminance differences always generate significant visually perceived differences, whereas significant hue and/or saturation differences do not always generate significant visually perceived differences

Steroid profiling by UHPLC-MS/MS in dried blood spots collected from healthy women with and without testosterone gel administration.

The quantification of a large panel of endogenous steroids in serum by LC-MS/MS represents a powerful clinical tool for the screening or diagnosis of diverse endocrine disorders. This approach has also demonstrated excellent sensitivity for the detection of testosterone misuse in the anti-doping field, especially in female athlete population. In both situations, the use of dried blood spots (DBS) could provide a viable alternative to invasive venous blood collection. Here, the evaluation of DBS sampling for the quantification of a panel of endogenous steroids using UHPLC-MS/MS is described. The UHPLC-MS/MS method was validated for quantitative analysis of eleven free and eight conjugated steroids and was then used for the analysis of DBS samples collected in 14 healthy women during a normal menstrual cycle (control phase) followed by a 28-days testosterone gel treatment (treatment phase). Results were compared with those obtained from serum matrix. Satisfactory performance was obtained for all compounds in terms of selectivity, linearity, accuracy, precision, combined uncertainty, stability as well as extraction recovery and matrix effects. In control phase, high correlation was observed between DBS and serum concentrations for most compounds. In treatment phase, higher testosterone concentrations were observed in capillary than in venous DBS, suggesting a possible interference resulting from testosterone contamination on finger(s) used for gel application. Steroid profiling in capillary DBS represents a simple and efficient strategy for monitoring endogenous steroid concentrations and their fluctuation in clinical context of steroid-related disorders, or for the detection of testosterone abuse in anti-doping

Straightforward quantification of endogenous steroids with liquid chromatography-tandem mass spectrometry: Comparing calibration approaches.

Different calibration strategies are used in liquid chromatography hyphenated to mass spectrometry (LC-MS) bioanalysis. Currently, the surrogate matrix and surrogate analyte represent the most widely used approaches to compensate for the lack of analyte-free matrices in endogenous compounds quantification. In this context, there is a growing interest in rationalizing and simplifying quantitative analysis using a one-point concentration level of stable isotope-labeled (SIL) standards as surrogate calibrants. Accordingly, an internal calibration (IC) can be applied when the instrument response is translated into analyte concentration via the analyte-to-SIL ratio performed directly in the study sample. Since SILs are generally used as internal standards to normalize variability between authentic study sample matrix and surrogate matrix used for the calibration, IC can be calculated even if the calibration protocol was achieved for an external calibration (EC). In this study, a complete dataset of a published and fully validated method to quantify an extended steroid profile in serum was recomputed by adapting the role of SIL internal standards as surrogate calibrants. Using the validation samples, the quantitative performances for IC were comparable with the original method, showing acceptable trueness (79%-115%) and precision (0.8%-11.8%) for the 21 detected steroids. The IC methodology was then applied to human serum samples (n = 51) from healthy women and women diagnosed with mild hyperandrogenism, showing high agreement (R <sup>2</sup> > 0.98) with the concentrations obtained using the conventional quantification based on EC. For IC, Passing-Bablok regression showed proportional biases between -15.0% and 11.3% for all quantified steroids, with an average difference of -5.8% compared to EC. These results highlight the reliability and the advantages of implementing IC in clinical laboratories routine to simplify quantification in LC-MS bioanalysis, especially when a large panel of analytes is monitored

Partial Derivation of Transformation Properties of Quarks and Leptons

Under the assumptions that $SU(3)_c\times U(1)_Y \times G^{\prime}$ with $G^{\prime}$ simple is a local symmetry group at high energies, that color is parity-conserving, and the Y-charges are irreducible, we show that anomaly constraints imply the minimal set of fermions is fifteen in number. Given this minimal set, we further show that $G^{\prime}$ must be $SU(2)$ and the unbroken gauge symmetry is {\it either} color {\it or} the product of color with electric charge.Comment: 9 pages, UMDHEP 94-72 and IFP-487-UN

Comparison of "Live High-Train Low" in Normobaric versus Hypobaric Hypoxia.

We investigated the changes in both performance and selected physiological parameters following a Live High-Train Low (LHTL) altitude camp in either normobaric hypoxia (NH) or hypobaric hypoxia (HH) replicating current "real" practices of endurance athletes. Well-trained triathletes were split into two groups (NH, n = 14 and HH, n = 13) and completed an 18-d LHTL camp during which they trained at 1100-1200 m and resided at an altitude of 2250 m (PiO2  = 121.7±1.2 vs. 121.4±0.9 mmHg) under either NH (hypoxic chamber; FiO2 15.8±0.8%) or HH (real altitude; barometric pressure 580±23 mmHg) conditions. Oxygen saturations (SpO2) were recorded continuously daily overnight. PiO2 and training loads were matched daily. Before (Pre-) and 1 day after (Post-) LHTL, blood samples, VO2max, and total haemoglobin mass (Hbmass) were measured. A 3-km running test was performed near sea level twice before, and 1, 7, and 21 days following LHTL. During LHTL, hypoxic exposure was lower for the NH group than for the HH group (220 vs. 300 h; P<0.001). Night SpO2 was higher (92.1±0.3 vs. 90.9±0.3%, P<0.001), and breathing frequency was lower in the NH group compared with the HH group (13.9±2.1 vs. 15.5±1.5 breath.min-1, P<0.05). Immediately following LHTL, similar increases in VO2max (6.1±6.8 vs. 5.2±4.8%) and Hbmass (2.6±1.9 vs. 3.4±2.1%) were observed in NH and HH groups, respectively, while 3-km performance was not improved. However, 21 days following the LHTL intervention, 3-km run time was significantly faster in the HH (3.3±3.6%; P<0.05) versus the NH (1.2±2.9%; ns) group. In conclusion, the greater degree of race performance enhancement by day 21 after an 18-d LHTL camp in the HH group was likely induced by a larger hypoxic dose. However, one cannot rule out other factors including differences in sleeping desaturations and breathing patterns, thus suggesting higher hypoxic stimuli in the HH group

Dithering algorithms for variable dot size printers

Dither-based methods for the halftoning of images on multi-level printing devices such as multi-level inkjet printers are presented. Due to the relatively large size of single droplets, halftoning algorithms are still needed. However, since halftoning occurs between the basic levels attainable by printing one, two or several droplets at the same position, artefacts are less visible than in equal resolution bilevel printers. When dithering algorithms are used for the halftoning task, the dither threshold tiles should have oblique orientations so as to make the halftoning artifacts less visible. They should be designed so as to break up the inherent artifacts of variable dot size printers, such as for example continuous lines made up of elongated elliptic dots. The resulting visual effects are shown by simulating the printed dots of a multilevel inkjet printe

Microquasars as sources of positron annihilation radiation

We consider the production of positrons in microquasars, i.e. X-ray binary systems that exhibit jets frequently, but not continuously. We estimate the production rate of positrons in microquasars, both by simple energy considerations and in the framework of various proposed models. We then evaluate the collective emissivity of the annihilation radiation produced by Galactic microquasars and we find that it might constitute a substantial contribution to the annihilation flux measured by INTEGRAL/SPI. We also discuss the possible spatial distribution of Galactic microquasars, on the basis of the (scarce) available data and the resulting morphology of the flux received on Earth. Finally, we consider nearby 'misaligned' microquasars, with jets occasionally hitting the atmosphere of the companion star; these would represent interesting point sources, for which we determine the annihilation flux and the corresponding light curve, as well as the line's spectral profile. We discuss the possibility of detection of such point sources by future instruments.Comment: 13 pages, 7 figures, accepted in A&