133 research outputs found
Augmentation Index Derived from Peripheral Arterial Tonometry Correlates with Cardiovascular Risk Factors
Background. Augmentation index (AIx) is traditionally obtained from pressure waveforms via arterial applanation tonometry. We sought to evaluate the association between
AIx obtained from peripheral arterial tonometry (PAT) with cardiovascular risk factors (CRF) and coronary artery disease (CAD).
Methods. 186 patients were enrolled in the study. The presence or absence of CRFs and CAD was assessed in each subject. AIx was calculated by an automated algorithm averaging pulse wave amplitude data obtained via PAT. Central blood pressures were assessed in a subset of patients undergoing clinically indicated cardiac catheterization. Results. An association was observed between AIx and age, heart rate, systolic blood pressure, mean arterial pressure, pulse pressure, body weight and body mass index. AIx was significantly lower in patients with <3
CRFs compared to those with >5 CRFs ( P = .02). CAD+ patients had significantly higher AIx compared to CAD− patients ( P = .008). Area under the ROC curve was 0.604 (P < .01). In patients undergoing cardiac catheterization, after adjusting for age, height and heart rate, AIx was a significant predictor of aortic systolic and pulse pressures (P < .05) Conclusion. AIx derived from PAT correlates with cardiac risk factors and CAD. It may be a useful measure of assessing overall risk for coronary artery disease
Now You See It, Now You Don't: The Disappearing Central Engine of the Quasar J1011+5442
We report the discovery of a new "changing-look" quasar, SDSS
J101152.98+544206.4, through repeat spectroscopy from the Time Domain
Spectroscopic Survey. This is an addition to a small but growing set of quasars
whose blue continua and broad optical emission lines have been observed to
decline by a large factor on a time scale of approximately a decade. The 5100
Angstrom monochromatic continuum luminosity of this quasar drops by a factor of
> 9.8 in a rest-frame time interval of < 9.7 years, while the broad H-alpha
luminosity drops by a factor of 55 in the same amount of time. The width of the
broad H-alpha line increases in the dim state such that the black hole mass
derived from the appropriate single-epoch scaling relation agrees between the
two epochs within a factor of 3. The fluxes of the narrow emission lines do not
appear to change between epochs. The light curve obtained by the Catalina Sky
Survey suggests that the transition occurs within a rest-frame time interval of
approximately 500 days. We examine three possible mechanisms for this
transition suggested in the recent literature. An abrupt change in the
reddening towards the central engine is disfavored by the substantial
difference between the timescale to obscure the central engine and the observed
timescale of the transition. A decaying tidal disruption flare is consistent
with the decay rate of the light curve but not with the prolonged bright state
preceding the decay, nor can this scenario provide the power required by the
luminosities of the emission lines. An abrupt drop in the accretion rate onto
the supermassive black hole appears to be the most plausible explanation for
the rapid dimming.Comment: Submitted to MNRA
Towards an Understanding of Changing-Look Quasars: An Archival Spectroscopic Search in SDSS
The uncertain origin of the recently-discovered `changing-looking' quasar
phenomenon -- in which a luminous quasar dims significantly to a quiescent
state in repeat spectroscopy over ~10 year timescales -- may present unexpected
challenges to our understanding of quasar accretion. To better understand this
phenomenon, we take a first step to building a sample of changing-look quasars
with a systematic but simple archival search for these objects in the Sloan
Digital Sky Survey Data Release 12. By leveraging the >10 year baselines for
objects with repeat spectroscopy, we uncover two new changing-look quasars, and
a third discovered previously. Decomposition of the multi-epoch spectra and
analysis of the broad emission lines suggest that the quasar accretion disk
emission dims due to rapidly decreasing accretion rates (by factors of >2.5),
while disfavoring changes in intrinsic dust extinction for the two objects
where these analyses are possible. Broad emission line energetics also support
intrinsic dimming of quasar emission as the origin for this phenomenon rather
than transient tidal disruption events or supernovae. Although our search
criteria included quasars at all redshifts and transitions from either
quasar-like to galaxy-like states or the reverse, all of the clear cases of
changing-look quasars discovered were at relatively low-redshift (z ~ 0.2 -
0.3) and only exhibit quasar-like to galaxy-like transitions.Comment: 15 pages, 8 figures. Updated to accepted versio
Chalcogenide Glass Optical Waveguides for Infrared Biosensing
Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 μm wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio)sensors
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors
Summary RIPK2 mediates pro-inflammatory signaling from the bacterial sensors NOD1 and NOD2, and is an emerging therapeutic target in autoimmune and inflammatory diseases. We observed that cellular RIPK2 can be potently inhibited by type II inhibitors that displace the kinase activation segment, whereas ATP-competitive type I inhibition was only poorly effective. The most potent RIPK2 inhibitors were the US Food and Drug Administration-approved drugs ponatinib and regorafenib. Their mechanism of action was independent of NOD2 interaction and involved loss of downstream kinase activation as evidenced by lack of RIPK2 autophosphorylation. Notably, these molecules also blocked RIPK2 ubiquitination and, consequently, inflammatory nuclear factor κB signaling. In monocytes, the inhibitors selectively blocked NOD-dependent tumor necrosis factor production without affecting lipopolysaccharide-dependent pathways. We also determined the first crystal structure of RIPK2 bound to ponatinib, and identified an allosteric site for inhibitor development. These results highlight the potential for type II inhibitors to treat indications of RIPK2 activation as well as inflammation-associated cancers
Identifying core features of adaptive metabolic mechanisms for chronic heat stress attenuation contributing to systems robustness
The contribution of metabolism to heat stress may play a significant role in defining robustness and recovery of systems; either by providing the energy and metabolites required for cellular homeostasis, or through the generation of protective osmolytes. However, the mechanisms by which heat stress attenuation could be adapted through metabolic processes as a stabilizing strategy against thermal stress are still largely unclear. We address this issue through metabolomic and transcriptomic profiles for populations along a thermal cline where two seagrass species, Zostera marina and Zostera noltii, were found in close proximity. Significant changes captured by these profile comparisons could be detected, with a larger response magnitude observed in northern populations to heat stress. Sucrose, fructose, and myo-inositol were identified to be the most responsive of the 29 analyzed organic metabolites. Many key enzymes in the Calvin cycle, glycolysis and pentose phosphate pathways also showed significant differential expression. The reported comparison suggests that adaptive mechanisms are involved through metabolic pathways to dampen the impacts of heat stress, and interactions between the metabolome and proteome should be further investigated in systems biology to understand robust design features against abiotic stress
A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection
10.1186/1471-2334-4-34BMC Infectious Diseases4-BIDM
Report of the Topical Group on Electroweak Precision Physics and Constraining New Physics for Snowmass 2021
The precise measurement of physics observables and the test of their
consistency within the standard model (SM) are an invaluable approach,
complemented by direct searches for new particles, to determine the existence
of physics beyond the standard model (BSM). Studies of massive electroweak
gauge bosons (W and Z bosons) are a promising target for indirect BSM searches,
since the interactions of photons and gluons are strongly constrained by the
unbroken gauge symmetries. They can be divided into two categories: (a) Fermion
scattering processes mediated by s- or t-channel W/Z bosons, also known as
electroweak precision measurements; and (b) multi-boson processes, which
include production of two or more vector bosons in fermion-antifermion
annihilation, as well as vector boson scattering (VBS) processes. The latter
categories can test modifications of gauge-boson self-interactions, and the
sensitivity is typically improved with increased collision energy.
This report evaluates the achievable precision of a range of future
experiments, which depend on the statistics of the collected data sample, the
experimental and theoretical systematic uncertainties, and their correlations.
In addition it presents a combined interpretation of these results, together
with similar studies in the Higgs and top sector, in the Standard Model
effective field theory (SMEFT) framework. This framework provides a
model-independent prescription to put generic constraints on new physics and to
study and combine large sets of experimental observables, assuming that the new
physics scales are significantly higher than the EW scale.Comment: 55 pages; Report of the EF04 topical group for Snowmass 202
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