65 research outputs found

    The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper-terpyridine compounds.

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    Three copper(II) coordination compounds have been prepared from three different 2,2′:6′,2′′-terpyridine-based ligands, which have been selected to investigate the potential role of supramolecular interactions on the DNA-interacting and cytotoxicity properties of the corresponding metal complexes. Hence, the ligands 4′-((naphthalen-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Naphtpy) and 4′-((1H-benzo[d]imidazol-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Bimztpy) have been synthesized from commercially-available 4′-chloro-2,2′:6′,2′′-terpyridine (Cltpy), and their copper(II) complexes have been obtained by reaction with copper(II) nitrate. The DNA-interacting abilities of the corresponding compounds [Cu(Cltpy)(H2O)(NO3)2] (1), [Cu(naphtpy)(NO3)(H2O)](NO3)(MeOH) (2) and [Cu(bimztpy)(NO3)(H2O)](NO3) (3) have been investigated using different techniques, and cytotoxicity assays with several cancer cell lines have revealed interesting features, viz. the more efficient complex is 2, which although it does not act as a DNA cleaver, displays the most effective DNA-interacting and cytotoxic properties, compared to 1 and 3

    Formation, Structure, and Morphology of Triazole-Based Langmuir-Blodgett Films

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    The formation, morphology, and structure of two-dimensional Langmuir-Blodgett (LB) assemblies of octadecyltriazole (ODT)-based metal-containing oligomers presenting, in the case of iron, the spin-crossover phenomenon is studied with Brewster angle microscopy, IR dichroism, X-ray diffraction, and atomic force microscopy. Two processes occurring at the air-water interface are confirmed to dominate the mechanism of formation of these LB films, the instability of the coordination polymers at the air-water interface and recoordination of metal ions in the subphase at the interface during the LB deposition process. The Langmuir film allowing the LB film formation is mostly made of ODT. The films do present a lamellar structure in which the ODT molecules are tilted and incorporate coordinated isolated metal ions and oligomers of metal ions. The morphology of the LB films is globally flat but with a rather high roughness resulting from inhomogeneities related to phenomena occurring during the LB film formation. These observations are in agreement with the relative affinity of the metal ions with ODT and the relative stability of the coordination polymers at the air-water interface, which have been determined for the group Cu-Fe-Co-Ni

    Manganese clusters derived from a 2,6-diacetylpyridine dioximato ligand: structure and magnetic study

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    Reactions of 2,6-diacetylpyridine dioxime (dapdoH2) with Mn(NO3)2 or Mn(SO3CF3)2 under a variety of conditions or co-ligands yield compounds with the formula [Mn6O2(OMe)2(dapdo)2(dapdoH)4](X)2 in which X = NO3− (1) or SO3CF3− (2), [Mn8O2(dapdo)6(NO3)2]·H2O (3) and [Mn(dapdoH2)(N3)2]n (4). Compounds 1, 3 and 4 were structurally characterized and equivalent structures for 1 and 2 were inferred from spectroscopic and analytical results. Compounds 1 and 2 consist of hexanuclear Mn2IIMn4III complexes whereas 3 consists of an octanuclear Mn6IIMn2III cluster in which the manganese atoms exhibit a rare bicapped elongated octahedral topology. Compound 4 consists of a 1D system bridged by double end-on azido ligands. Variable temperature magnetic studies were performed between 2–300 K, confirming the ground state S = 5 for 1 and 2, S = 0 for 3 and ferromagnetic response for 4

    Highly cytotoxic DNA-interacting copper(ii) coordination compounds

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    Four new Schiff-base ligands have been designed and prepared by condensation reaction between hydrazine derivatives (i.e. 2-hydrazinopyridine or 2-hydrazinoquinoline) and mono- or dialdehyde (3-tert-butyl-2-hydroxybenzaldehyde and 5-tert-butyl-2-hydroxyisophthalaldehyde, respectively). Six copper(II) coordination compounds of various nuclearities have been obtained from these ligands, which are formulated as [Cu(L1)Cl](CH3OH) (1), [Cu(L2)NO3] (2), [Cu2(L3)(ClO4)2(CH3O)(CH3OH)](CH3OH) (3), [Cu2(L4)(ClO4)(OH)(CH3OH)](ClO4) (4), [Cu8(L3)4(NO3)4(OH)5](NO3)3(CH3OH)5(H2O)8 (5) and [Cu3(HL2′)4Cl6](CH3OH)6 (6), as revealed by single-crystal X-ray studies. Their DNA-interacting abilities have been investigated using different characterization techniques, which suggest that the metal complexes act as efficient DNA binders. Moreover, cytotoxicity assays with several cancer cell lines show that some of them are very active, as evidenced by the sub-micromolar IC50 values achieved in some cases

    Highly cytotoxic DNA-interacting copper(II) coordination compounds

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    et al.Four new Schiff-base ligands have been designed and prepared by condensation reaction between hydrazine derivatives (i.e. 2-hydrazinopyridine or 2-hydrazinoquinoline) and mono- or dialdehyde (3-tert-butyl-2-hydroxybenzaldehyde and 5-tert-butyl-2-hydroxyisophthalaldehyde, respectively). Six copper(ii) coordination compounds of various nuclearities have been obtained from these ligands, which are formulated as [Cu(L1)Cl](CH3OH) (1), [Cu(L2)NO3] (2), [Cu2(L3)(ClO4)2(CH3O)(CH3OH)](CH3OH) (3), [Cu2(L4)(ClO4)(OH)(CH3OH)](ClO4) (4), [Cu8(L3)4(NO3)4(OH)5](NO3)3(CH3OH)5(H2O)8 (5) and [Cu3(HL2′)4Cl6](CH3OH)6 (6), as revealed by single-crystal X-ray studies. Their DNA-interacting abilities have been investigated using different characterization techniques, which suggest that the metal complexes act as efficient DNA binders. Moreover, cytotoxicity assays with several cancer cell lines show that some of them are very active, as evidenced by the sub-micromolar IC50 values achieved in some cases.PG acknowledges ICREA (Institució Catalana de Recerca i Estudis Avançats) and the Ministerio de Economía y Competitividad (MINECO) of Spain (Project CTQ2011-27929-C02-01). The support of COST Action CM1105 is kindly acknowledged. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences of the U. S. Department of Energy under contract no. DE-AC02-05CH11231. OR acknowledges the Ministerio de Economía y Competitividad of Spain (Project MAT2011-24284).Peer Reviewe
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