Politicians’ ability to survive a scandal is more to do with their ability to govern and maintain coalition than with the public’s approval

Last week we saw New Jersey Governor Chris Christie embroiled in what has become known as the ‘Bridgegate’ scandal. But what are the factors that make a scandal last longer or shorten them? Brandon Rottinghaus has made an in-depth study of national and state-level scandals, finding that at state level they generally last for less than 100 days, and around six months for presidential-level scandals. He finds that elected officials are far more likely to survive scandals as opposed to appointees, because, having been elected; they are simply harder to remove, and that a greater degree of legislative opposition makes scandals harder to overcome

A study for comprehensive and collaborative relationships: Partnering public schools and nonprofit outdoor programs

My research paper will explore the divide between urban youth and their participation in outdoor programs. In an effort to provide a foundation of reason for the lack of participation in outdoor programs by urban youth, this study will be completed through an abstract approach on heuristic research and constraint theory. Heuristic research can be defined as the process of researching a “personal venture in search of understanding one’s self and the world around them” (Moustakas, 1990). In addition, constraint theory focuses on the barriers individuals face in regards to participation in activities or the completion of a goal (Samdahl & Jekubovich, 1997). By delving into the literature surrounding this topic I will identify the barriers that are keeping public schools from utilizing the opportunities that quality outdoor programs may offer as well as the pedagogies and methods of a few successful outdoor programs who seek to foster the development of healthy intrapersonal and social skill sets of urban youth (Outward Bound, 2010; Elkind, 2007; Kolb, 1984). I will also research current educational institutions in the Des Moines Metro to determine potential partnerships. The other purpose of this study is to research and explore ways urban classrooms and outdoor programs may partner to offer both their curricula to youth with the intent of fostering active and more effective contributing members of a rapidly changing society

Presidential Greatness & Political Science: Assessing the 2014 APSA Presidents & Executive Politics Section Presidential Greatness Survey

Debates about presidential greatness have been with us for decades, facilitated in part by numerous systematic surveys of scholars with expertise in American history and politics. Nevertheless, the voice of political scientists in this debate has been relatively muted when compared particularly with the role that historians have had in making these determinations. This article introduces and assesses results of a recent effort to capture the attitudes of political science presidency experts about presidential greatness. By surveying the membership of the APSA Presidents and Executive Politics section, we could identify and then compare specifically the attitudes of political scientists against the growing body of ratings and rankings of a phenomenon with long-standing interest and importance

The C Terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit

Ku is a heterodimeric protein with double-stranded DNA end-binding activity that operates in the process of nonhomologous end joining. Ku is thought to target the DNA-dependent protein kinase (DNA-PK) complex to the DNA and, when DNA bound, can interact and activate the DNA-PK catalytic subunit (DNA-PKcs). We have carried out a 3′ deletion analysis of Ku80, the larger subunit of Ku, and shown that the C-terminal 178 amino acid residues are dispensable for DNA end-binding activity but are required for efficient interaction of Ku with DNA-PKcs. Cells expressing Ku80 proteins that lack the terminal 178 residues have low DNA-PK activity, are radiation sensitive, and can recombine the signal junctions but not the coding junctions during V(D)J recombination. These cells have therefore acquired the phenotype of mouse SCID cells despite expressing DNA-PKcs protein, suggesting that an interaction between DNA-PKcs and Ku, involving the C-terminal region of Ku80, is required for DNA double-strand break rejoining and coding but not signal joint formation. To gain further insight into important domains in Ku80, we report a point mutational change in Ku80 in the defective xrs-2 cell line. This residue is conserved among species and lies outside of the previously reported Ku70-Ku80 interaction domain. The mutational change nonetheless abrogates the Ku70-Ku80 interaction and DNA end-binding activity

In deciding how to exercise power via Executive Orders, US Presidents appeal to Congress only if it can be united

Recent months have seen Republican attacks on President Obama, accusing him of presiding over an ‘imperial presidency’, but to what extent do presidents actually operate completely outside of Congress’ powers? By looking at 5,000 executive orders issued by presidents over the last 80 years Jeremy D. Bailey and Brandon Rottinghaus find that when issuing these orders, presidents tend to appeal back to Congress when the majority party is strong, and act unilaterally when the majority is weak and divided

Celecoxib concentration predicts decrease in prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk women

BACKGROUND: Epidemiologic studies suggest that long term low dose celecoxib use significantly lowers breast cancer risk. We previously demonstrated that 400 mg celecoxib taken twice daily for 2 weeks lowered circulating plasma and breast nipple aspirate fluid (NAF) prostaglandin (PG)E2 concentrations in post- but not premenopausal high risk women. We hypothesized that circulating concentrations of celecoxib influenced PGE2 response, and that plasma levels of the drug are influenced by menopausal status. To address these hypotheses, the aims of the study were to determine: 1) if circulating plasma concentrations of celecoxib correlated with the change in plasma or NAF PGE2 concentrations from baseline to end of treatment, and 2) whether menopausal status influenced circulating levels of celecoxib. METHODS: Matched NAF and plasma were collected from 46 high risk women who were administered celecoxib twice daily for two weeks, 20 subjects receiving 200 mg and 26 subjects 400 mg of the agent. NAF and plasma samples were collected before and 2 weeks after taking celecoxib. RESULTS: In women taking 400 mg bid celecoxib, plasma concentrations of the agent correlated inversely with the change in NAF PGE2 levels from pre- to posttreatment. Nonsignificant trends toward higher celecoxib levels were observed in post- compared to premenopausal women. There was a significant decrease in NAF but not plasma PGE2 concentrations in postmenopausal women who took 400 mg celecoxib (p = 0.03). CONCLUSION: In high risk women taking 400 mg celecoxib twice daily, plasma concentrations of celecoxib correlated with downregulation of PGE2 production by breast tissue. Strategies synergistic with celecoxib to downregulate PGE2 are of interest, in order to minimize the celecoxib dose required to have an effect