Effective field theory approach to Casimir interactions on soft matter surfaces

We utilize an effective field theory approach to calculate Casimir interactions between objects bound to thermally fluctuating fluid surfaces or interfaces. This approach circumvents the complicated constraints imposed by such objects on the functional integration measure by reverting to a point particle representation. To capture the finite size effects, we perturb the Hamiltonian by DH that encapsulates the particles' response to external fields. DH is systematically expanded in a series of terms, each of which scales homogeneously in the two power counting parameters: \lambda \equiv R/r, the ratio of the typical object size (R) to the typical distance between them (r), and delta=kB T/k, where k is the modulus characterizing the surface energy. The coefficients of the terms in DH correspond to generalized polarizabilities and thus the formalism applies to rigid as well as deformable objects. Singularities induced by the point particle description can be dealt with using standard renormalization techniques. We first illustrate and verify our approach by re-deriving known pair forces between circular objects bound to films or membranes. To demonstrate its efficiency and versatility, we then derive a number of new results: The triplet interactions present in these systems, a higher order correction to the film interaction, and general scaling laws for the leading order interaction valid for objects of arbitrary shape and internal flexibility.Comment: 4 pages, 1 figur

The Phenomenology of Inclusive Heavy-to-Light Sum Rules

By calculating the O(\alpha_s) corrections to inclusive heavy-to-light sum rules we find model independent upper and lower bounds on form factors for B to pi and B to rho. We use the bounds to rule out model predictions. Some models violate the bounds only for certain ranges of sum rule input parameters \bar{lambda} \simeq m_B-m_b and lambda_1, or for certain choices of model parameters, while others obey or violate the bounds irrespective of the inputs. We discuss the reliability and convergence of the bounds, point out their utility for extracting V_{ub}, and derive from them a new form factor scaling relation.Comment: 15 pages, 3 figures include

ScreenMill: A freely available software suite for growth measurement, analysis and visualization of high-throughput screen data

<p>Abstract</p> <p>Background</p> <p>Many high-throughput genomic experiments, such as Synthetic Genetic Array and yeast two-hybrid, use colony growth on solid media as a screen metric. These experiments routinely generate over 100,000 data points, making data analysis a time consuming and painstaking process. Here we describe <it>ScreenMill</it>, a new software suite that automates image analysis and simplifies data review and analysis for high-throughput biological experiments.</p> <p>Results</p> <p>The <it>ScreenMill</it>, software suite includes three software tools or "engines": an open source <it>Colony Measurement Engine </it>(<it>CM Engine</it>) to quantitate colony growth data from plate images, a web-based <it>Data Review Engine </it>(<it>DR Engine</it>) to validate and analyze quantitative screen data, and a web-based <it>Statistics Visualization Engine </it>(<it>SV Engine</it>) to visualize screen data with statistical information overlaid. The methods and software described here can be applied to any screen in which growth is measured by colony size. In addition, the <it>DR Engine </it>and <it>SV Engine </it>can be used to visualize and analyze other types of quantitative high-throughput data.</p> <p>Conclusions</p> <p><it>ScreenMill </it>automates quantification, analysis and visualization of high-throughput screen data. The algorithms implemented in S<it>creenMill </it>are transparent allowing users to be confident about the results <it>ScreenMill </it>produces. Taken together, the tools of <it>ScreenMill </it>offer biologists a simple and flexible way of analyzing their data, without requiring programming skills.</p

Identification of Functionally Distinct TRAF Proinflammatory and PI3K/MEK Transforming Activities Emanating from the RET/PTC Fusion Oncoprotein

Thyroid carcinomas that harbor RET/PTC oncogenes are well differentiated, relatively benign neoplasms compared with those expressing oncogenic RAS or BRAF mutations despite signaling through shared transforming pathways. A distinction, however, is that RET/PTCs induce immunostimulatory programs, suggesting that, in the case of this tumor type, the additional pro-inflammatory pathway reduces aggressiveness. Here, we demonstrate that pro-inflammatory programs are selectively activated by TRAF2 and TRAF6 association with RET/PTC oncoproteins. Eliminating this mechanism reduces pro-inflammatory cytokine production without decreasing transformation efficiency. Conversely, ablating MEK/ERK or PI3K/AKT signaling eliminates transformation but not pro-inflammatory cytokine secretion. Functional uncoupling of the two pathways demonstrates that intrinsic pro-inflammatory pathways are not required for cellular transformation and suggests a need for further investigation into the role inflammation plays in thyroid tumor progression

N=1 Supersymmetric SU(2)rSU(2)^r Moose Theories

We study the quantum moduli spaces and dynamical superpotentials of four dimensional $SU(2)^r$ linear and ring moose theories with $\mathcal{N}=1$ supersymmetry and link chiral superfields in the fundamental representation. Nontrivial quantum moduli spaces and dynamical superpotentials are produced. When the moduli space is perturbed by generic tree level superpotentials, the vacuum space becomes discrete. The ring moose is in the Coulomb phase and we find two singular submanifolds with a nontrivial modulus that is a function of all the independent gauge invariants needed to parameterize the quantum moduli space. The massive theory near these singularities confines. The Seiberg-Witten elliptic curve that describes the quantum moduli space of the ring moose is produced.Comment: 26 pages, 4 figures. A few comments and references added. To appear in PR

Power Corrections in Charmless Nonleptonic B-Decays: Annihilation is Factorizable and Real

We classify LambdaQCD/mb power corrections to nonleptonic B-> M1 M2 decays, where M1 and M2 are charmless non-isosinglet mesons. Using recent developments in soft-collinear effective theory, we prove that the leading contributions to annihilation amplitudes of O[alphas(mb) LambdaQCD/mb] are real and are determined by nonperturbative functions that already occur in the lowest order B-> M1 M2 factorization theorem. A complex nonperturbative parameter from annihilation first appears at O[alphas^2(sqrt{Lambda mb}) LambdaQCD/mb]. ``Chirally enhanced'' contributions are also factorizable and real at lowest order. Thus, incalculable strong phases are suppressed in annihilation amplitudes, unless the alphas(sqrt{Lambda mb}) expansion breaks down. Modeling the distribution functions, we find that (11 +- 9)% and (15 +- 11)% of the absolute value of the measured B-> K- pi+ and B-> K- K0 penguin amplitudes come from annihilation. This is consistent with the expected size of power corrections

Fluid-Induced Propulsion of Rigid Particles in Wormlike Micellar Solutions

In the absence of inertia, a reciprocal swimmer achieves no net motion in a viscous Newtonian fluid. Here, we investigate the ability of a reciprocally actuated particle to translate through a complex fluid that possesses a network using tracking methods and birefringence imaging. A geometrically polar particle, a rod with a bead on one end, is reciprocally rotated using magnetic fields. The particle is immersed in a wormlike micellar (WLM) solution that is known to be susceptible to the formation of shear bands and other localized structures due to shear-induced remodeling of its microstructure. Results show that the nonlinearities present in this WLM solution break time-reversal symmetry under certain conditions, and enable propulsion of an artificial "swimmer." We find three regimes dependent on the Deborah number (De): net motion towards the bead-end of the particle at low De, net motion towards the rod-end of the particle at intermediate De, and no appreciable propulsion at high De. At low De, where the particle time-scale is longer then the fluid relaxation time, we believe that propulsion is caused by an imbalance in the fluid first normal stress differences between the two ends of the particle (bead and rod). At De~1, however, we observe the emergence of a region of network anisotropy near the rod using birefringence imaging. This anisotropy suggests alignment of the micellar network, which is "locked in" due to the shorter time-scale of the particle relative to the fluid