32 research outputs found

    Independent risk loci.

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    <p><b>Independent GWAS Loci.</b> Table of independent associations with prostate cancer. Index SNPs with are grouped together, and shown with source citations. A locus with a significant number of correlated SNPs at for two index SNPs that don't meet the cutoff are also considered the same locus. Also shown are the nearby genes (Gene) and population in which the associations were reported (Ethn).</p

    Enrichment of Gene Ontology.

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    <p>Representative ontology clusters from DAVID <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004102#pgen.1004102-Huang1" target="_blank">[37]</a> enrichment analysis of nearby genes given in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004102#pgen-1004102-t001" target="_blank">Table 1</a>. Green boxes indicate membership of the genes (as columns) with the annotations (as rows). A. Transcription factor cluster. B. Male gonad development cluster.</p

    Transcription Factor Response Elements are not enriched in PCa GWAS SNPs.

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    <p> express number of observed response element disruptions as a proportion relative to the standard deviation from the background distribution. The regression line is shown in blue with 95% confidence interval. Transcription factors of interest are highlighted with blue text. The inner box (dotted line) demarcates the 95% C.I. of a bootstrapped distribution for each PWM. A bonferroni box is outside the bounds of the graphic.</p

    Results of <i>Funci{SNP}</i> analysis of GWAS correlated SNPs.

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    <p>Index SNPs with biofeatures and correlated SNPs at are combined and summarized in A–D. A. SNP counts by value. B. SNP counts by biofeature. Some SNPs map to more than one biofeature, hence the total does not sum to 727. C. Classification of 727 SNPs by <i>putative</i> functional category. D. Supervised clustering of SNPs by biofeature.</p

    Primer sequences.

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    <p><b>Primers used in cloning enhancers for reporter assays.</b> The underlined portion highlights the and sites used for site-directed cloning of the PCR product. The PSA control is described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004102#pgen.1004102-Jia1" target="_blank">[7]</a>.</p
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