Spatial distribution and synoptic conditions of snow accumulation in the Russian Arctic

Snow accumulation and associated synoptic conditions in the Russian Arctic are analysed based on snow depth data from 1950 to 2013 from the All-Russian Research Institute of Hydrometeorological Information—World Data Centre data set. The mean duration of snow coverage in the Russian Arctic is approximately eight to nine months. While the period of snowmelt is usually very short (one or two months), snow accumulates during most of the cold season (October–May). Snow accumulation is associated with negative anomalies of sea level pressure and positive anomalies of air temperature, which means increased cyclonic activity over the analysed region. The cyclones differ in intensity and localization, depending on the area of snowfall. In the western part of the Russian Arctic the cyclones and air masses that bring snowfall may originate from the North Atlantic, while in the eastern part they originate from the Bering Sea, Okhotsk Sea or the North Pacific. The cyclones that bring snowfall may also form locally along the zonal border between two different air masses: the very cold, polar, continental air originating from the Siberian High and the Arctic air from the north, which is often warmer and always more humid than the continental air

Pattern recognition by pentraxins

Pentraxins are a family of evolutionarily conserved pattern-recognition proteins that are made up of five identical subunits. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver while PTX3 is produced in a variery oftissues during inflammation. The main functions of short pentraxins are to recognize a variery of pathogenic agents and then to either eliminate them or neutralize their harmful effects by utilizing the complement pathways and macrophages in the host. CRP binds to modified low-densiry lipoproteins, bacterial polysaccharides, apoptotic cells, and nuclear materials. By virtue of these recognition functions, CRP participates in the resolution ofcardiovascular, infectious, and autoimmune diseases. SAP recognizes carbohydrates, nuclear substances, and amyloid fibrils and thus participates in the resolution of infectious diseases, autoimmuniry, and amyloidosis. PTX3 interacts with several ligands, including growth factors, extracellular matrix component and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagoeytes. In addition, data in gene-targeted mice show that PTX3 is essential in female fertiliry, participating in the assembly of the cumulus oophorus extracellular matrix. PTX3 is therefore a nonredundant component ofthe humoral arm of innate immuniry as well as a tuner of inflammation. Thus, in conjunction with the other components ofinnate immuniry, the pentraxins use their pattern-recognition properry for the benefit of the host