Debajyoti Choudhury

Gluon fusion into a very heavy neutrino pair by Higgs exchange is shown to lead to substantial production cross sections at $pp$ supercolliders even without any extra generation of quarks. Rates are calculated for scalar as well as pseudoscalar Higgs. The angular correlation between dileptons emerging from the decays of the neutrinos shows distinctive features for Dirac and Majorana neutrinos as well as for scalar and pseudoscalar Higgs

Optimisation of Bifacial Photovoltaics Module with Reflective Layer in Outdoor Performance

While the improvements of STC maximum power point (Pmpp) and current from inserting reflective layers in the inter-cell gap of bifacial modules have been reported, there are many additional factors that contribute to the module outdoor performance in addition to the module STC performance. This paper presents the analysis and optimisation of bifacial PV modules with reflective layer at the inter-cell gap for outdoor performance. Bifacial module with reflective layer was studied where the reflective surfaces are inserted behind the rear glass. Normal glass/glass bifacial modules were compared to the proposed bifacial modules with reflective layers that were fabricated with the same cell type. A numerical model was created to simulate the current gain from each configuration with varying outdoor conditions. The numerical model was verified with an outdoor performance set-up that was experimentally constructed

pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains

Cellular global translation is often measured using ribosome profiling or quantitative mass spectrometry, but these methods do not provide direct information at the level of elongating nascent polypeptide chains (NPCs) and associated co-translational events. Here, we describe pSNAP, a method for proteome-wide profiling of NPCs by affinity enrichment of puromycin- and stable isotope-labeled polypeptides. pSNAP does not require ribosome purification and/or chemical labeling, and captures bona fide NPCs that characteristically exhibit protein N-terminus-biased positions. We applied pSNAP to evaluate the effect of silmitasertib, a potential molecular therapy for cancer, and revealed acute translational repression through casein kinase II and mTOR pathways. We also characterized modifications on NPCs and demonstrated that the combination of different types of modifications, such as acetylation and phosphorylation in the N-terminal region of histone H1.5, can modulate interactions with ribosome-associated factors. Thus, pSNAP provides a framework for dissecting co-translational regulations on a proteome-wide scale

Tau Signals of R-parity breaking at LEP 200

The detectability at LEP 200 of explicit $R$-parity breaking by tau-number $(L_\tau)$ violating operators is considered. The assumption of $L_\tau$-violation is motivated by the relative lack of constraints on such couplings but similar considerations apply to explicit $L_e$- or $L_\mu$-violation. The $LSP$, now unstable, and not necessarily neutral, decays via $L_\tau$-violating modes. Only signals from the production and decays of $LSP$ pairs are considered, thereby avoiding any dependence on the sparticle mass spectrum. Rather spectacular signals are predicted: spherical events with $m$ leptons (usually containing at least one $\tau$) and $n$ jets $(m,n \leq 4)$, the most characteristic of which are like-sign $\tau\tau$ events. These signals are enumerated for each $LSP$ candidate and quantitative estimates are provided for the favoured case when the $LSP$ is a neutralino. Other new physics signals, which can mimic these signatures, are also briefly discussed.Comment: 27 pages in PHYZZX, six figures (not included, available on request). TIFR/TH/92-29,UH-511-751-92,CERN-TH.6613/9

Summary of the Activities of the Working Group I on High Energy and Collider Physics

This is a summary of the projects undertaken by the Working Group I on High Energy Collider Physics at the Eighth Workshop on High Energy Physics Phenomenology (WHEPP8) held at the Indian Institute of Technology, Mumbai, January 5-16, 2004. The topics covered are (i) Higgs searches (ii) supersymmetry searches (iii) extra dimensions and (iv) linear collider.Comment: summary of Working Group I at the Eighth Workshop on High Energy Physics Phenomenology (WHEPP8), I.I.T., Mumbai, January 5-16, 200

Great Lakes Runoff Intercomparison Project Phase 3: Lake Erie (GRIP-E)

Hydrologic model intercomparison studies help to evaluate the agility of models to simulate variables such as streamflow, evaporation, and soil moisture. This study is the third in a sequence of the Great Lakes Runoff Intercomparison Projects. The densely populated Lake Erie watershed studied here is an important international lake that has experienced recent flooding and shoreline erosion alongside excessive nutrient loads that have contributed to lake eutrophication. Understanding the sources and pathways of flows is critical to solve the complex issues facing this watershed. Seventeen hydrologic and land-surface models of different complexity are set up over this domain using the same meteorological forcings, and their simulated streamflows at 46 calibration and seven independent validation stations are compared. Results show that: (1) the good performance of Machine Learning models during calibration decreases significantly in validation due to the limited amount of training data; (2) models calibrated at individual stations perform equally well in validation; and (3) most distributed models calibrated over the entire domain have problems in simulating urban areas but outperform the other models in validation

Comprehensive molecular characterization of gastric adenocarcinoma

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers