Uveitis and Acute Interstitial Nephritis: What to Expect

A 46-year-old female patient presenting with acute interstitial nephritis and anterior uveitis was admitted. The renal biopsy disclosed the presence of interstitial nephritis, confirming the clinical diagnosis of tubulointerstitial nephritis and uveitis (TINU) syndrome. Treatment with oral steroids was started, with prompt improvement of symptoms and laboratory abnormalities

Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

We report a case of a 64-year-old male who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease

ESTUDIO CLÍNICO-EPIDEMIOLÓGICO DE 301 PERSONAS ATENDIDAS EN LA REPÚBLICA DE HAITÍ

Se realizó un estudio clínico-epidemiológico observacional descriptivo de 301 personas atendidas en la República de Haití, en el período comprendido del 20 marzo del 2012 al 20 mayo del 2012 en el Servicio de Medicina y Terapia del Hospital Departemental du Centre Sainte Thérése de Hinche. La naturaleza social del conocimiento es destacada en el sentido de insistir en su función social, así como en el compromiso y la responsabilidad de la ciencia y los científicos. Se realizó un estudio clínico-epidemiológico observacional descriptivo, se le aplicó una encuesta  para el control y la tipificación de las patologías, validadas en anteriores estudios realizados. El objetivo de la investigación es conocer los rasgos clínico-epidemiológicos de la población haitiana que se asociaron a sus hábitos de vida y factores de riesgo personales. En el estudio realizado se confirma la estrecha relación clínico-epidemiológica de los trastornos que existen en la República de Haití. La literatura afirma que la mala disposición final de las excretas, unido a la exposición a vectores, consumo de bebidas que contienen alcohol, sedentarismo, contribuye  a la aparición de patologías que aumentan la mortalidad. Al conocer los rasgos clínico-epidemiológicos de la población haitiana asociados a sus hábitos de vida y factores de riesgo personales, se pueden prevenir muchos problemas de salud

CARACTERIZACIÓN DE LA LEPTOSPIROSIS EN 271 PERSONAS ATENDIDAS EN EN EL HOSPITAL UNIVERSITARIO “DR. ANTONIO LUACES IRAOLA”

Lo que da origen a esta investigación, es la prevención responsable del riesgo de contraer leptospirosis, qué se desconoce cómo evitarla. En el mundo la leptospirosis es una antrozoonosis que afecta a más de 160 especies de animales salvajes y domésticos que constituyen el reservorio y la fuente de infección para el hombre. Las especies más afectas son los roedores salvajes y los animales domésticos, especialmente los perros, el ganado bovino, porcino, ovino y equino. Se organizó un formulario para la recogida de datos individuales que incluyó las diferentes variables de estudio, se emplearon las evidencias significativas y el análisis de datos, se consultaran expertos en encuentros científicos, con profesionales de experiencia en el tema, en las etapas de elaboración y/o validación al respecto, además los datos obtenidos se compararon con la literatura nacional y extranjera actualizada. El objetivo fundamental  es caracterizar el comportamiento clínico-epidemiológico de leptospirosis en 271 personas atendidas en en el Hospital Universitario Dr. Antonio Luaces Iraolaen el período comprendido de octubre de 2008 a junio de 2011. No existió letalidad por leptospirosis, en los casos ingresados en el Servicio de Medicina del Hospital Universitario Dr. Antonio Luaces Iraola en el período estudiado, lo que demuestra una conducta correcta seguida en los mismos, que comparado con estudios de otros autores varía, entre el 2,2 y el 9,7%, no así cuando el trastorno ocurre en el embarazo, que letalidad la fetal es alta. El comportamiento clínico-epidemiológico de leptospirosis, coincide con la edad en que se realizan mayores labores agrícolas, que están íntimamente relacionadas con los factores predictivos o síntomas premonitorios

On the origin of X-shaped radio galaxies

After a brief, critical review of the leading explanations proposed for the small but important subset of radio galaxies showing an X-shaped morphology (XRGs) we propose a generalized model, based on the jet-shell interaction and spin-flip hypotheses. The most popular scenarios for this intriguing phenomenon invoke either hydrodynamical backflows and over-pressured cocoons or rapid jet reorientations, presumably from the spin-flips of central engines following the mergers of pairs of galaxies, each of which contains a supermassive black hole (SMBH). We confront these models with a number of key observations and thus argue that none of the models is capable of explaining the entire range of salient observational properties of XRGs, although some of the arguments raised in the literature against the spin-flip scenario are probably not tenable. We then propose here a new scenario which also involves galactic mergers but would allow the spin of the central engine to maintain its direction. Motivated by the detailed multi-band observations of the nearest radio galaxy, Centaurus A, this new model emphasizes the role of interactions between the jets and the shells of stars and gas that form and rotate around the merged galaxy and can cause temporary deflections of the jets, occasionally giving rise to an X-shaped radio structure. Although each of the models is likely to be relevant to a subset of XRGs, the bulk of the evidence indicates that most of them are best explained by the jet-shell interaction or spin-flip hypotheses.Comment: 19 pages, major revision including two Appendices and a Table, accepted in Research in Astronomy and Astrophysic

Ciencias de la Biología y Agronomía

Este volumen I contiene 17 capítulos arbitrados que se ocupan de estos asuntos en Tópicos Selectos de Ciencias de la Biología y Agronomía, elegidos de entre las contribuciones, reunimos algunos investigadores y estudiantes. Se presenta un Estudio Comparativo de los Recursos Hidrológico-Forestales de la Microcuenca de la Laguna de Epatlan, Pue. (1993 a 2014); la Situación Actual de la Mancha de Asfalto en Maíz (Zea mays L.) en los Municipios de Jiquipilas y Ocozocoautla, Chiapas, México; las poblaciones sobresalientes de maíz de la raza Zapalote Chico, en la Región Istmeña de Oaxaca; Se indica el índice de área foliar de cultivo de Chile Poblano mediante dos métodos en condiciones protegidas; Esquivel, Urzúa y Ramírez exploran el efecto de la biofertilización con Azospirillum en el crecimiento y producción de Jitomate; esbozan su artículo sobre la determinación del nivel de Heterosis en híbridos de Maíz para la Comarca Lagunera; una investigación sobre la estabilización de semilla de Solanum lycopersicum durante el almacenamiento y estimulación de la germinación; acotan sobre el CTAB como una nueva opción para la detección de Huanglongbing en cítricos, plantean su evaluación sobre el aluminio y cómo afecta la vida de florero de Heliconia psittacorum; indican sobre el impacto del H-564C, como un híbrido de maíz con alta calidad de proteina para el trópico húmedo de México; presetan su investigación sobre la producción de Piña Cayena Lisa y MD2 (Ananas comosus L.) en condiciones de Loma Bonita, en Oaxaca; acotan sobre el efecto de coberteras como control biológico por conservación contra áfidos en Nogal Pecanero; esbozan sobre la caracterización de cuatro genotipos de Frijol Negro en Martínez de la Torre, Veracruz, México; presentan una caracterización hidroecológica de la microcuenca de Arroyo Prieto, Yuriría, Gto., y alternativas para su restauración ambiental; presentan su investigación sobre el efecto del hongo Beauveria bassiana sobre solubilización de fosfatos y la disponibilidad de fósforo en el suelo; plantean su investigación sobre la Germinación y regeneración in vitro de Epidendrum falcatum LINDL; esbozan su artículo sobre genotipos de frijol negro y su tolerancia a sequía terminal en Veracruz, México

Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression

The clinicopathological features of the hamster model of visceral leishmaniasis (VL) closely mimic active human disease. Studies in humans and hamsters indicate that the inability to control parasite replication in VL could be related to ineffective classical macrophage activation. Therefore, we hypothesized that the pathogenesis of VL might be driven by a program of alternative macrophage activation. Indeed, the infected hamster spleen showed low NOS2 but high arg1 enzyme activity and protein and mRNA expression (p<0.001) and increased polyamine synthesis (p<0.05). Increased arginase activity was also evident in macrophages isolated from the spleens of infected hamsters (p<0.05), and arg1 expression was induced by L. donovani in primary hamster peritoneal macrophages (p<0.001) and fibroblasts (p<0.01), and in a hamster fibroblast cell line (p<0.05), without synthesis of endogenous IL-4 or IL-13 or exposure to exogenous cytokines. miRNAi-mediated selective knockdown of hamster arginase 1 (arg1) in BHK cells led to increased generation of nitric oxide and reduced parasite burden (p<0.005). Since many of the genes involved in alternative macrophage activation are regulated by Signal Transducer and Activator of Transcription-6 (STAT6), and because the parasite-induced expression of arg1 occurred in the absence of exogenous IL-4, we considered the possibility that L. donovani was directly activating STAT6. Indeed, exposure of hamster fibroblasts or macrophages to L. donovani resulted in dose-dependent STAT6 activation, even without the addition of exogenous cytokines. Knockdown of hamster STAT6 in BHK cells with miRNAi resulted in reduced arg1 mRNA expression and enhanced control of parasite replication (p<0.0001). Collectively these data indicate that L. donovani infection induces macrophage STAT6 activation and STAT6-dependent arg1 expression, which do not require but are amplified by type 2 cytokines, and which contribute to impaired control of infection

ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats

An update to the 2007 American College of Veterinary Internal Medicine (ACVIM) consensus statement on the identification, evaluation, and management of systemic hypertension in dogs and cats was presented at the 2017 ACVIM Forum in National Harbor, MD. The updated consensus statement is presented here. The consensus statement aims to provide guidance on appropriate diagnosis and treatment of hypertension in dogs and cats

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life