The Noose That Builds the Nation: Mexican Lynching in the Southwest

In North from Mexico: the Spanish Speaking People of the United States, Carey McWilliams asserts that more Mexicans were lynched in the southwest between 1865 and 1920 than blacks in other parts of the south. The hundreds of unrestrained murders of Mexicans throughout the southwest have gone largely unrecognized in U.S. and Chicano/a histories. Previous work on lynching has focused on the murders of African Americans in the South. Those works that have discussed violence against Mexicans in the southwest in this period conflate lynching murders with generalized stories on frontier violence and vigilantism. In addition, no work has been published that considers modern southwestern lynchings of Mexicans. Why has the lynching of Mexicans been largely unwritten and the losses of these lynching victims unvalued? I examine how nation building and the consolidation of national belonging have been constructed through ritualized, performative violence. Brutal murders of Mexicans have been replicated for over a century in the southwest--today by vigilante groups in San Diego County, at the Arizona state border, and throughout the southwest. I suggest a larger look at the lynching of Mexicans in the southwest as coupled with expansionism and colonialism--historically and in the present

Establishing a \u27Place of Hope\u27 In a Homeless Shelter for Families and Children

This project analyzes the critical leadership style of the management team, including this writer, in establishing A Place of Hope\u27 at a homeless shelter (The Shelter) for families and children located in a major city in the Upper Midwest Region. This project will assess the author\u27s use of the following characteristics found in critical leadership: critical in nature, transformative in style, educative in form, and ethical in character (Foster, 1986, p.52). This project took place from 1999 to 2001

Optimization of Oleosin 30G Production for Echocardiography

Provided they are uniform in size, monodisperse microbubbles behave as contrast agents to enhance echocardiographic imaging. Compounds like Oleosin 30G with surfactant-like properties help stabilize microbubbles - thereby ensuring their uniform size. Designed herein is an industrial-scale plant to produce medical-grade Oleosin 30G with a process consisting of three steps: 1) upstream production via recombinant E. coli in an integrated batch bioprocessing model, 2) downstream purification, and 3) processing by microfluidic manifolds. Ultimately Oleosin 30G-coated microbubbles are manufactured, ready for injection within one month. Owing to its unique properties and cost-effective production, Oleosin 30G has the potential to outcompete current market leader Definity®. Altogether, overall yield of Oleosin 30G constitutes 7.39 kg/year to provide for 100% market saturation. Financial analysis indicates pursuing Oleosin 30G for echocardiography applications is very profitable with a 296% return on investment and holds potential for production expansion should the market demand increase

Scanning History

Digitizing yearbooks makes Linfield\u27s history more accessible and connecte

Memantine Improves Attentional Processes in Fragile X-Associated Tremor/Ataxia Syndrome: Electrophysiological Evidence from a Randomized Controlled Trial.

Progressive cognitive deficits are common in patients with fragile X-associated tremor/ataxia syndrome (FXTAS), with no targeted treatment yet established. In this substudy of the first randomized controlled trial for FXTAS, we examined the effects of NMDA antagonist memantine on attention and working memory. Data were analyzed for patients (24 in each arm) who completed both the primary memantine trial and two EEG recordings (at baseline and follow-up) using an auditory "oddball" task. Results demonstrated significantly improved attention/working memory performance after one year only for the memantine group. The event-related potential P2 amplitude elicited by non-targets was significantly enhanced in the treated group, indicating memantine-associated improvement in attentional processes at the stimulus identification/discrimination level. P2 amplitude increase was positively correlated with improvement on the behavioral measure of attention/working memory during target detection. Analysis also revealed that memantine treatment normalized the P2 habituation effect at the follow-up visit. These findings indicate that memantine may benefit attentional processes that represent fundamental components of executive function/dysfunction, thought to comprise the core cognitive deficit in FXTAS. The results provide evidence of target engagement of memantine, as well as therapeutically relevant information that could further the development of specific cognitive or disease-modifying therapies for FXTAS

Patient-reported measures of well-being in older multiple myeloma patients: use of secondary data source

Background!#!Changes in well-being of patients with multiple myeloma (MM) before and after diagnosis have not been quantified.!##!Aims!#!Explore the use of secondary data to examine the changes in the well-being of older patients with MM.!##!Methods!#!We used the Health and Retirement Study (HRS), linked to Medicare claims to identify older MM patients. We compared patient-reported measures (PRM), including physical impairment, sensory impairment, and patient experience (significant pain, self-rated health, depression) in the interviews before and after MM diagnosis using McNemar's test. We propensity-matched each MM patient to five HRS participants without MM diagnosis based on baseline characteristics. We compared the change in PRM between the MM patients and their matches.!##!Results!#!We identified 92 HRS patients with MM diagnosis (mean age = 74.6, SD = 8.4). Among the surviving patients, there was a decline in well-being across most measures, including ADL difficulty (23% to 40%, p value = 0.016), poor or fair self-rated health (38% to 61%, p value = 0.004), and depression (15% to 30%, p value = 0.021). Surviving patients reported worse health than participants without MM across most measures, including ADL difficulty (40% vs. 27%, p value = 0.04), significant pain (38% vs. 22%, p value = 0.01), and depression (29% vs. 11%, p value = 0.003).!##!Discussion!#!Secondary data were used to identify patients with MM diagnosis, and examine changes across multiple measures of well-being. MM diagnosis negatively affects several aspects of patients' well-being, and these declines are larger than those experienced by similar participants without MM.!##!Conclusion!#!The results of this study are valuable addition to understanding the experience of patients with MM, despite several data limitations

Spatio-temporal analysis of malaria incidence in the Peruvian Amazon Region between 2002 and 2013.

Malaria remains a major public health problem in the Peruvian Amazon where the persistence of high-risk transmission areas (hotspots) challenges the current malaria control strategies. This study aimed at identifying significant space-time clusters of malaria incidence in Loreto region 2002-2013 and to determine significant changes across years in relation to the control measures applied. Poisson regression and purely temporal, spatial, and space-time analyses were conducted. Three significantly different periods in terms of annual incidence rates (AIR) were identified, overlapping respectively with the pre-, during, and post- implementation control activities supported by PAMAFRO project. The most likely space-time clusters of malaria incidence for P. vivax and P. falciparum corresponded to the pre- and first two years of the PAMAFRO project and were situated in the northern districts of Loreto, while secondary clusters were identified in eastern and southern districts with the latest onset and the shortest duration of PAMAFRO interventions. Malaria in Loreto was highly heterogeneous at geographical level and over time. Importantly, the excellent achievements obtained during 5 years of intensified control efforts totally vanished in only 2 to 3 years after the end of the program, calling for sustained political and financial commitment for the success of malaria elimination as ultimate goal

Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety

Advancements in rheumatoid arthritis (RA) treatment protocols and introduction of targeted biological therapies have markedly improved patient outcomes, despite this, up to 50% of patients still fail to achieve a significant clinical response. In veterinary medicine, stem cell therapy in the form of autologous stromal vascular fraction (SVF) is an accepted therapeutic modality for degenerative conditions with 80% improvement and no serious treatment associated adverse events reported. Clinical translation of SVF therapy relies on confirmation of veterinary findings in targeted patient populations. Here we describe the rationale and preclinical data supporting the use of autologous SVF in treatment of RA, as well as provide 1, 3, 6, and 13 month safety outcomes in 13 RA patients treated with this approach