IPSC differentiation into ependymal progenitors to treat ventricular damage during hydrocephalus

Introduction: During both obstructive congenital hydrocephalus and post-hemorrhagic hydrocephalus additional pathological events are intimately associated with their ethiology: a) a detrimental inflammatory response; b) severe damage of the underlying periventricular nervous tissue, including white matter, and c). Therapeutic approaches have been directed to overcome a) and b), however recovery of damaged neuroepithelium/ependyma is, in our present, an important therapeutic gap. Methods: Human and mouse induced pluripotent stem cells (iPSC) have been artificially differented into ependymal progenitors. Intracerebroventricular (ICV) injections of iPCS are performed ex vivo and in vivo in the damaged ventricular wall. Their integration and differentiation has been studied by immunohistochemistry and histopathological analysis. Results: Mice and human ependymal progenitors are able to integrate and differentiate into ependyma in damaged ventricular wall. Stage of ependymal differentiation by the time of the injection defined different degrees of integration. Conclusions: IPSC appear to be a good ependymal progenitor source with no ethical controversy associated.RyC 2014-16980 Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Modelos mecánicos de los materiales granulares sueltos empleados en firmes de carreteras

[Resumen:] En los firmes de carreteras los materiales granulares sueltos desempeñan un importante papel estructural. Esto es así porque por un lado, durante la etapa de construcción del firme soportan el tráfico de obra y proporcionan un cimiento sobre el cual las capas superiores puedan situarse y compactarse y, por otro lado, en un firme terminado actúan como amortiguadores de las cargas del tráfico. En este artículo se expone una breve descripción de algunos modelos de predicción del comportamiento resiliente de los materiales granulares bajo las cargas del tráfic

La deformabilidad de la explanada y el análisis de firmes: 2ª parte, comprobación estructural de las secciones de la 6.1 y 6.2 I.C.

Este curso tuvo lugar en A Coruña, del 6 al 8 de noviembre de 2000

Diseño de firmes mediante el empleo de modelos de predicción del comportamiento de los materiales granulares

Este VI congreso tivo lugar en León do 24 ao 27 de maio de 2004

La deformabilidad de la explanada y el análisis de firmes: 1ª parte, métodos de dimensionamiento de firmes

Este curso tuvo lugar en A Coruña, del 6 al 8 de noviembre de 200

Permanent deformation models for a granular material used in road pavements

[Abstract:] This paper analyses the permanent deformation performance of an unbound granular material that has been subjected to repeated triaxial loads. The study focuses on the evolution of the cumulative strain and includes a classification of the specimens according to the shakedown concept. This was done by fitting models that express the cumulative strain to cyclic loads and stress level. The predictions of the models were not absolutely perfect. The results with the granular material were not satisfactory enough to warrant their use in a low traffic road pavement section in Galicia (Spain)

A Sub-μVRms Chopper Front-End for ECoG Recording

This paper presents a low-noise, low-power fully differential chopper-modulated front-end circuit intended for ECoG signal recording. Among other features, it uses a subthreshold source-follower biquad in the forward path to reduce noise and avoid the implementation of a ripple rejection loop. The prototype was designed in 0.18μm CMOS technology with a 1V supply. Post-layout simulations were carried out showing a power consumption below 2μW and an integrated input-referred noise of 0.75μV rms , with a noise floor below 50 nV√Hz, over a bandwidth from 1 to 200Hz, for a noise efficiency factor of 2.7.Ministerio de Economía y Empresa TEC2016-80923-

A High TCMRR, Inherently Charge Balanced Bidirectional Front-End for Multichannel Closed-Loop Neuromodulation

This paper describes a multichannel bidirectional front-end for implantable closed-loop neuromodulation. Stimulation artefacts are reduced by way of a 4-channel H-bridge current source sharing stimulator front-end that minimizes residual charge drops in the electrodes via topology-inherent charge balancing. A 4-channel chopper front-end is capable of multichannel recording in the presence of artefacts as a result of its high total common-mode rejection ratio (TCMRR) that accounts for CMRR degradation due to electrode mismatch. Experimental verification of a prototype fabricated in a standard 180 nm process shows a stimulator front-end with 0.059% charge balance and 0.275 nA DC current error. The recording front-end consumes 3.24 µW, tolerates common-mode interference up to 1 Vpp and shows a TCMRR > 66 dB for 500 mVpp inputs.Ministerio de Economía y Competitividad TEC2016-80923-POffice of Naval Research (USA) N00014111031

Estudio de las deformaciones resilientes de los materiales granulares sueltos utilizados en capas de base de carreteras

Este congreso tivo lugar en París do 11 ao 15 de xuño de 2001