Heavy Rainfall Warning Assessment Tool User Guide. Version 1.2

This report is a User Guide to a PC tool for assessing Heavy Rainfall Warnings. Development of the PC tool formed an important operational output of the Environment Agency and Met Office funded project: "Development of Rainfall Forecast Performance Monitoring Criteria. Phase 1: Development of Methodology and Algorithms" (Jones et al., 2003). The Heavy Rainfall Warning (HRW) Assessment Tool is a toolkit for Microsoft Excel. The tool allows the user to configure an assessment framework for a particular format of Heavy Rainfall Warning, enter and save data for forecasts and ground-truths, and generate a range of performance measures and other statistics for new and previously saved data. Summary tables are presented using Excel's PivotTable feature, from which charts can also be generated. Performance measures are provided to assess forecasts of heavy rainfall in continuous variable, categorical and probability form: these include bias, rmse, R-squared Efficiency, skill scores and the Continuous Brier Score

Composition dependence of ion transport coefficients in gas mixtures

A simple momentum-transfer theory for the composition dependence of ion mobilities and diffusion coefficients in gas mixtures at arbitrary field strengths is corrected, extended, and compared with a similar theory based on momentum and energy transfer, and with results based on direct solution of the Boltzmann equation by Kihara's method. Final equations are recommended for predicting composition dependences, given only results on ion mobilities and diffusion coefficients in the pure component gases

Efficient Follow-Up of Exoplanet Transits Using Small Telescopes

11 pages, 5 figures, to be published in PASP, comments welcomeHere, we introduce an online tool for the prediction of exoplanet transit light curves. Small telescopes can readily capture exoplanet transits under good weather conditions when the combination of a bright star and a large transiting exoplanet results in a significant depth of transit. However, in reality there are many considerations that need to be made to obtain useful measurements. This paper and the accompanying website lay out a procedure based on timeseries differential photometry that has been successfully employed using 0.4 m aperture telescopes to predict the expected precision for a whole light curve. This enables robust planning to decide whether the observation of a particular exoplanet transit should be attempted, and in particular to be able to readily see when it should not to be attempted. This may result in a significant increase in the number of transit observations captured by non-specialists. The technique and website are also appropriate for planning a variety of variable star observations where a prediction of the light curve can be made.Peer reviewe

Local and Global Superconductivity in Bismuth

We performed magnetization M(H,T) and magnetoresistance R(T,H) measurements on powdered (grain size ~ 149 micrometers) as well as highly oriented rhombohedral (A7) bismuth (Bi) samples consisting of single crystalline blocks of size ~ 1x1 mm2 in the plane perpendicular to the trigonal c-axis. The obtained results revealed the occurrence of (1) local superconductivity in powdered samples with Tc(0) = 8.75 \pm 0.05 K, and (2) global superconductivity at Tc(0) = 7.3 \pm 0.1 K in polycrystalline Bi triggered by low-resistance Ohmic contacts with silver (Ag) normal metal. The results provide evidence that the superconductivity in Bi is localized in a tiny volume fraction, probably at intergrain or Ag/Bi interfaces. On the other hand, the occurrence of global superconductivity observed for polycrystalline Bi can be accounted for by enhancement of the superconducting order parameter phase stiffness induced by the normal metal contacts, the scenario proposed in the context of "pseudogap regime" in cuprates [E. Berg et al., PRB 78, 094509 (2008)].Comment: 12 pages including 9 figures and 1 table, Special Issue to the 80th birthday anniversary of V. G. Peschansky, Electronic Properties of Conducting System

Mammographic image restoration using maximum entropy deconvolution

An image restoration approach based on a Bayesian maximum entropy method (MEM) has been applied to a radiological image deconvolution problem, that of reduction of geometric blurring in magnification mammography. The aim of the work is to demonstrate an improvement in image spatial resolution in realistic noisy radiological images with no associated penalty in terms of reduction in the signal-to-noise ratio perceived by the observer. Images of the TORMAM mammographic image quality phantom were recorded using the standard magnification settings of 1.8 magnification/fine focus and also at 1.8 magnification/broad focus and 3.0 magnification/fine focus; the latter two arrangements would normally give rise to unacceptable geometric blurring. Measured point-spread functions were used in conjunction with the MEM image processing to de-blur these images. The results are presented as comparative images of phantom test features and as observer scores for the raw and processed images. Visualization of high resolution features and the total image scores for the test phantom were improved by the application of the MEM processing. It is argued that this successful demonstration of image de-blurring in noisy radiological images offers the possibility of weakening the link between focal spot size and geometric blurring in radiology, thus opening up new approaches to system optimization.Comment: 18 pages, 10 figure

Observables in the Decays of B to Two Vector Mesons

In general there are nine observables in the decay of a B meson to two vector mesons defined in terms of polarization correlations of these mesons. Only six of these can be detected via the subsequent decay angular distributions because of parity conservation in those decays. The remaining three require the measurement of the spin polarization of one of the decay products.Comment: 12 pages, no figur

Symptoms and treatment of copper deficiency of wheat

Copper deficiency in wheat is still common but may not be easily noticed

Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes

Epitope-tagged active-site-directed probes are widely used to visualize the activity of deubiquitinases (DUBs) in cell extracts, to investigate the specificity and potency of small-molecule DUB inhibitors, and to isolate and identify DUBs by mass spectrometry. With DUBs arising as novel potential drug targets, probes are required that can be produced in sufficient amounts and to meet the specific needs of a given experiment. The established method for the generation of DUB probes makes use of labor-intensive intein-based methods that have inherent limitations concerning the incorporation of unnatural amino acids and the amount of material that can be obtained. Here, we describe the total chemical synthesis of active-site-directed probes and their application to activity-based profiling and identification of functional DUBs. This synthetic methodology allowed the easy incorporation of desired tags for specific applications, for example, fluorescent reporters, handles for immunoprecipitation or affinity pull-down, and cleavable linkers. Additionally, the synthetic method can be scaled up to provide significant amounts of probe. Fluorescent ubiquitin probes allowed faster, in-gel detection of active DUBs, as compared to (immuno)blotting procedures. A biotinylated probe holding a photocleavable linker enabled the affinity pull-down and subsequent mild, photorelease of DUBs. Also, DUB activity levels were monitored in response to overexpression or knockdown, and to inhibition by small molecules. Furthermore, fluorescent probes revealed differential DUB activity profiles in a panel of lung and prostate cancer cells