String Theory on AdS_3

It was shown by Brown and Henneaux that the classical theory of gravity on AdS_3 has an infinite-dimensional symmetry group forming a Virasoro algebra. More recently, Giveon, Kutasov and Seiberg (GKS) constructed the corresponding Virasoro generators in the first-quantized string theory on AdS_3. In this paper, we explore various aspects of string theory on AdS_3 and study the relation between these two works. We show how semi-classical properties of the string theory reproduce many features of the AdS/CFT duality. Furthermore, we examine how the Virasoro symmetry of Brown and Henneaux is realized in string theory, and show how it leads to the Virasoro Ward identities of the boundary CFT. The Virasoro generators of GKS emerge naturally in this analysis. Our work clarifies several aspects of the GKS construction: why the Brown-Henneaux Virasoro algebra can be realized on the first-quantized Hilbert space, to what extent the free-field approximation is valid, and why the Virasoro generators act on the string worldsheet localized near the boundary of AdS_3. On the other hand, we find that the way the central charge of the Virasoro algebra is generated is different from the mechanism proposed by GKS.Comment: 22 pages, 4 figures, LateX; references added, minor correction

Dementia detectives: Busting the myths

yesDescribes the one-hour dementia awareness programme developed for secondary schools

Population Genetic Structure in Channeled Whelk Busycotypus canaliculatus along the U.S. Atlantic Coast

Globally, commercial fisheries for whelk (family Buccinidae) generally exhibit a boom-and-bust cycle that fuels overexploitation of resources. Channeled whelk Busycotypus canaliculatus is a commercially important species that supports a valuable fishery along the Atlantic coast of the United States. The fishery is managed at the state level, with minimum landing size varying by state. Biological studies of channeled whelk in New England and the mid-Atlantic region have indicated that females have a low probability of maturity upon entering their respective fisheries. The life history characteristics of channeled whelk, including slow growth, late maturation, and direct development paired with unsuitable minimum landing size, make this species vulnerable to overexploitation. Currently, the population genetic structure of channeled whelk is unknown, impeding the ability to appropriately inform management. This study used 2,570 single nucleotide polymorphisms to elucidate the population genetic structure of channeled whelk sampled from 10 locations ranging from Massachusetts to South Carolina. The data indicated seven genetically distinct populations across the sampled region of the U.S. Atlantic coast. Estimates of genetic divergence among populations spanned an order of magnitude (FST = 0.017–0.582), with higher levels of divergence observed when comparing populations separated by biogeographic barriers. Based on the magnitude of observed genetic differences, five regional management units are suggested. The results of this study will aid discussions among fisheries managers in Atlantic states aimed at the development of appropriate management plans. The complex population genetic structure revealed by this study underscores the need for more comprehensive sampling, including between fishing locations sampled in this study and among offshore locations, to better understand the population genetic structure of channeled whelk

The Third wave in globalization theory

This essay examines a proposition made in the literature that there are three waves in globalization theory—the globalist, skeptical, and postskeptical or transformational waves—and argues that this division requires a new look. The essay is a critique of the third of these waves and its relationship with the second wave. Contributors to the third wave not only defend the idea of globalization from criticism by the skeptics but also try to construct a more complex and qualified theory of globalization than provided by first-wave accounts. The argument made here is that third-wave authors come to conclusions that try to defend globalization yet include qualifications that in practice reaffirm skeptical claims. This feature of the literature has been overlooked in debates and the aim of this essay is to revisit the literature and identify as well as discuss this problem. Such a presentation has political implications. Third wavers propose globalist cosmopolitan democracy when the substance of their arguments does more in practice to bolster the skeptical view of politics based on inequality and conflict, nation-states and regional blocs, and alliances of common interest or ideology rather than cosmopolitan global structures

Embracing the variety of sustainable business models: Social entrepreneurship, corporate intrapreneurship, creativity, innovation, and other approaches to sustainability challenges

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The future of coal in a carbon-constrained climate

Phasing out coal requires expanding the notion of a ‘just transition’ and a roadmap that specifies the sequence of coal plant retirement, the appropriate policy instruments as well as ways to include key stakeholders in the process

Measuring capacity building in communities: a review of the literature

<p>Abstract</p> <p>Background</p> <p>Although communities have long been exhorted to make efforts to enhance their own health, such approaches have often floundered and resulted in little or no health benefits when the capacity of the community has not been adequately strengthened. Thus being able to assess the capacity building process is paramount in facilitating action in communities for social and health improvement. The current review aims to i) identify all domains used in systematically documented frameworks developed by other authors to assess community capacity building; and ii) to identify the dimensions and attributes of each of the domains as ascribed by these authors and reassemble them into a comprehensive compilation.</p> <p>Methods</p> <p>Relevant published articles were identified through systematic electronic searches of selected databases and the examination of the bibliographies of retrieved articles. Studies assessing capacity building or community development or community participation were selected and assessed for methodological quality, and quality in relation to the development and application of domains which were identified as constituents of community capacity building. Data extraction and analysis were undertaken using a realist synthesis approach.</p> <p>Results</p> <p>Eighteen articles met the criteria for this review. The various domains to assess community capacity building were identified and reassembled into nine comprehensive domains: "learning opportunities and skills development", "resource mobilization", "partnership/linkages/networking", "leadership", "participatory decision-making", "assets-based approach", "sense of community", "communication", and "development pathway". Six sub-domains were also identified: "shared vision and clear goals", "community needs assessment", "process and outcome monitoring", "sustainability", "commitment to action" and "dissemination".</p> <p>Conclusions</p> <p>The set of domains compiled in this review serve as a foundation for community-based work by those in the field seeking to support and nurture the development of competent communities. Further research is required to examine the robustness of capacity domains over time and to examine capacity development in association with health or other social outcomes.</p

Doing more with less: productivity or starvation? The intellectual asset health check

The recent wave of savings in public service expenditure comes at the risk of creating starved workplaces, depleted of intellectual assets. This paper examines the perils of starved workplaces and how to avoid them. Organizations that nurture their intellectual assets were found to outperform their peers with 13.3% higher productivity. These organizations created a ‘win–win situation’, achieving both productivity targets while sustaining high stocks of emotional and human capital

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study

BACKGROUND: Tendinosis lesions show an increase of glycosaminoglycan amount, calcifications, and lipid accumulation. Therefore, altered cellular differentiation might play a role in the etiology of tendinosis. This study investigates whether adolescent human tendon tissue contains a population of cells with intrinsic differentiation potential. METHODS: Cells derived from adolescent non-degenerative hamstring tendons were characterized by immunohistochemistry and FACS-analysis. Cells were cultured for 21 days in osteogenic, adipogenic, and chondrogenic medium and phenotypical evaluation was carried out by immunohistochemical and qPCR analysis. The results were compared with the results of similar experiments on adult bone marrow-derived stromal cells (BMSCs). RESULTS: Tendon-derived cells stained D7-FIB (fibroblast-marker) positive, but α-SMA (marker for smooth muscle cells and pericytes) negative. Tendon-derived cells were 99% negative for CD34 (endothelial cell marker), and 73% positive for CD105 (mesenchymal progenitor-cell marker). In adipogenic medium, intracellular lipid vacuoles were visible and tendon-derived fibroblasts showed upregulation of adipogenic markers FABP4 (fatty-acid binding protein 4) and PPARG (peroxisome proliferative activated receptor γ). In chondrogenic medium, some cells stained positive for collagen 2 and tendon-derived fibroblasts showed upregulation of collagen 2 and collagen 10. In osteogenic medium Von Kossa staining showed calcium deposition although osteogenic markers remained unaltered. Tendon-derived cells and BMCSs behaved largely comparable, although some distinct differences were present between the two cell populations. CONCLUSION: This study suggests that our population of explanted human tendon cells has an intrinsic differentiation potential. These results support the hypothesis that there might be a role for altered tendon-cell differentiation in the pathophysiology of tendinosis