Navigating the Information Needs of Online & Remote Students: Charting a New Course

National is a non-traditional university that provides higher education to working adults in an accelerated (one-month) format. It is projected that by the end of 2007 over half of the 22,000 FTE students will be taking classes online. To meet this change in student demographics, the Library changed its service model and now provides all library instruction online via voice and video over the internet or as web-based interactive tutorials. The move to synchronous training over the Internet has called on us to develop new pedagogical approaches to our instruction to encourage active learning and HOTS (higher order thinking skills). Through the process, faculty have been surveyed for their perceptions of student competencies for skills they see as critical to success in their programs. The content from the library instruction list of over 25 classes serves as the baseline for developing parallel multimedia tutorials and just-in-time training aids. This presentation focuses on three aspects of this new service model: Collaborating with faculty to better integrate information literacy into the curriculum; exploring online pedagogies and assessment; and redesigning library presence to better meet student needs. Participants will be able to view a demonstration of the online class sessions

JISC funded Kaptur project environmental assessment report

The overall objective of the JISC funded Kaptur project (October 2011 - March 2013) is to discover, create and pilot a sectoral model of best practice in the management of research data in the visual arts. This report outlines findings from the first workpackage, environmental assessment, based on the following research question: What is the nature of visual arts research data? Appendix A provides detail on the methodology; data was gathered from a literature review and 16 face-to-face interviews with visual arts researchers; four at each partner institution: Glasgow School of Art; Goldsmiths, University of London; University for the Creative Arts; and University of the Arts London

The hidden harm: alcohol’s impact on children and families

Examines the prevalence and effects of heavy drinking on families and children, and the extent to which they persisted or changed over time. Summary The 2015 study examined the prevalence and effects of heavy drinking on families and children, and the extent to which they persisted or changed over time. It paints a concerning picture of the prevalence of alcohol-related family and domestic violence in Australia, shedding new light on a hidden dimension of alcohol harms that occurs largely behind closed doors. Key findings The hidden harm draws on two national surveys of alcohol’s harm to others, service system data and qualitative interviews with families, providing for the first time a detailed and valuable insight into the magnitude of the problem and the large numbers of Australian children who are being put at risk. In 2011 there were 29,684 police-reported incidents of alcohol-related domestic violence in Australia, and that’s just in the four states and territories where this data is available. Children are being verbally abused, left in unsupervised or unsafe situations, physically hurt or exposed to domestic violence because of others’ drinking. Many were also witnessing verbal or physical conflict, drinking or inappropriate behaviour. Over a million children (22 per cent of all Australian children) are estimated to be affected in some way by the drinking of others (2008). 142,582 children were substantially affected (2008), and more than 10,000 Australian children are in the child protection system because of a carers drinking (2006-07)

An exploration of social justice intent in photovoice research studies from 2008 to 2013

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108344/1/nin12064.pd

Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

International audienceNumerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450. Depending of their nature and their severity, the mitochondrial alterations are able to induce mild to fulminant hepatic cytolysis and steatosis (lipid accumulation), which can have different clinical and pathological features. Microvesicular steatosis, a potentially severe liver lesion usually associated with liver failure and profound hypoglycemia, is due to a major inhibition of mitochondrial fatty acid oxidation (FAO). Macrovacuolar steatosis, a relatively benign liver lesion in the short term, can be induced not only by a moderate reduction of mitochondrial FAO but also by an increased hepatic de novo lipid synthesis and a decreased secretion of VLDL-associated triglycerides. Moreover, recent investigations suggest that some drugs could favor lipid deposition in the liver through primary alterations of white adipose tissue (WAT) homeostasis. If the treatment is not interrupted, steatosis can evolve toward steatohepatitis, which is characterized not only by lipid accumulation but also by necroinflammation and fibrosis. Although the mechanisms involved in this aggravation are not fully characterized, it appears that overproduction of reactive oxygen species by the damaged mitochondria could play a salient role. Numerous factors could favor drug-induced mitochondrial and metabolic toxicity, such as the structure of the parent molecule, genetic predispositions (in particular those involving mitochondrial enzymes), alcohol intoxication, hepatitis virus C infection, and obesity. In obese and diabetic patients, some drugs may induce acute liver injury more frequently while others may worsen the pre-existent steatosis (or steatohepatitis)

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

Alzheimer's amyloid precursor protein 695 (APP) is a plasma membrane protein, which is known to be the source of the toxic amyloid β (Aβ) peptide associated with the pathogenesis of Alzheimer's disease (AD). Here we demonstrate that by virtue of its chimeric NH2-terminal signal, APP is also targeted to mitochondria of cortical neuronal cells and select regions of the brain of a transgenic mouse model for AD. The positively charged residues at 40, 44, and 51 of APP are critical components of the mitochondrial-targeting signal. Chemical cross-linking together with immunoelectron microscopy show that the mitochondrial APP exists in NH2-terminal inside transmembrane orientation and in contact with mitochondrial translocase proteins. Mutational studies show that the acidic domain, which spans sequence 220–290 of APP, causes the transmembrane arrest with the COOH-terminal 73-kD portion of the protein facing the cytoplasmic side. Accumulation of full-length APP in the mitochondrial compartment in a transmembrane-arrested form, but not lacking the acidic domain, caused mitochondrial dysfunction and impaired energy metabolism. These results show, for the first time, that APP is targeted to neuronal mitochondria under some physiological and pathological conditions

Women\u27s Experiences in the Transition from Capstone Design Courses to Engineering Workplaces

Substantial research over the past few decades has documented the challenges women experience both as students in engineering programs and as professionals in engineering workplaces. Few studies, however, have followed women from one context to the other to explore the ways in which school experiences, and particularly capstone experiences designed to facilitate this transition, do and do not prepare women for their work as practicing engineers. To address this gap, we draw on data from a larger multi-institution study to address the question, “How do women experience the transition from engineering school to engineering work?” Participants for this study are drawn from a larger study across four universities (three mechanical engineering programs and one engineering science program). All participants identified as “female” on a screening questionnaire that included options for transgender and gender-nonconforming, as well as an option to skip the question. The full data set includes interviews with the participants conducted at the end of their capstone design course, responses to open-ended questions sent each week during their first 12 weeks of work, and interviews conducted after three, six, and 12 months of work. To answer the research question, we used purposeful sampling to identify four women whose interviews represented different trajectories across this school-to-work transition; we then used constructed narrative analysis to present their individual stories and identify salient points of similarity and difference for discussion. We also present implications for engineering educators, including that life-long learning should be expected, communication and collaboration are as essential workplace skills as technical competencies, and that gender is not necessarily a homogenizing force. Above all, we emphasize the power of the individual voice in better understanding the experiences of our students

The Prediction Accuracy of Digital Orthodontic Setups for the Orthodontic Phase before Orthognathic Surgery.

The purpose of this study was to verify whether pre-treatment digital setups can accurately predict the tooth positions after presurgical orthodontic treatment has been performed in a 3-dimensional way. Twenty-six patients who underwent a combined orthodontic-orthognathic surgical treatment were included. Pre-treatment digital dental models were merged with cone beam computed tomography (CBCT) scans. One operator fabricated virtual setups to simulate the tooth movements of the presurgical orthodontic treatment. Prior to surgery, digital dental models were merged with the CBCT scans. Differences between de virtual setups and the presurgical dental models were calculated using linear mixed model analyses. Differences in tooth displacements exceeding the boundaries of clinical acceptance (>2 degrees for rotations and >0.6 mm for translations) were found in 75% of the rotational and 52% of translational mean differences in the maxilla and in 74% of the rotational mean differences and 44% of the translational mean differences in the mandible. Significant differences were found for all tooth types and in all tooth displacement directions with significant effects of extractions and surgically assisted rapid maxillary expansion (SARME) procedures. The accuracy of the digital setup is still too limited to correctly simulate the presurgical orthodontic treatment

Longitudinal Three-Dimensional Stereophotogrammetric Growth Analysis in Infants with Unilateral Cleft Lip and Palate from 3 to 12 Months of Age

This longitudinal study aimed to evaluate facial growth and soft tissue changes in infants with complete unilateral cleft lip, alveolus, and palate (CUCLAP) at ages 3, 9, and 12 months. Using 3D images of 22 CUCLAP infants, average faces and distance maps for the entire face and specific regions were created. Color-coded maps highlighted more significant soft tissue changes from 3 to 9 months than from 9 to 12 months. The first interval showed substantial growth in the entire face, particularly in the forehead, eyes, lower lip, chin, and cheeks (p < 0.001), while the second interval exhibited no significant growth. This study provides insights into facial soft tissue growth in CUCLAP infants during critical developmental stages, emphasizing substantial improvements between 3 and 9 months, mainly in the chin, lower lip, and forehead. However, uneven growth occurred in the upper lip, philtrum, and nostrils throughout both intervals, with an overall decline in growth from 9 to 12 months. These findings underscore the dynamic nature of soft tissue growth in CUCLAP patients, highlighting the need to consider these patterns in treatment planning. Future research should explore the underlying factors and develop customized treatment interventions for enhanced facial aesthetics and function in this population