A spectroscopic search for AGN activity in the reionization era

The ubiquity of Lyman alpha (Ly$\alpha$) emission in a sample of four bright [O III]-strong star-forming galaxies with redshifts above 7 has led to the suggestion that such luminous sources represent a distinct population compared to their fainter, more numerous, counterparts. The presence of Ly$\alpha$ emission within the reionization era could indicate that these sources created early ionized bubbles due to their unusually strong radiation, possibly due to the presence of active galactic nuclei. To test this hypothesis we have secured long integration spectra with XSHOOTER on the VLT for three $z\simeq$7 sources selected to have similar luminosities and prominent excess fluxes in the IRAC 3.6 or 4.5$\mu$m band, usually attributed to strong [O III] emission. We secured additional spectroscopy for one of these galaxies at $z$=7.15 using MOSFIRE at the Keck telescope. For this, the most well-studied source in our sample with the strongest IRAC excess, we detect prominent nebular emission from He II and NV indicative of a non-thermal source. For the other two sources at $z$=6.81 and $z$=6.85, for which no previous optical/near infrared spectroscopy was initially available, Ly$\alpha$ is seen in one and CIII] emission in the other. Although a modest sample, our results further support the hypothesis that the phenomenon of intense [O III] emission is associated preferentially with sources lying in early ionized bubbles. However, even though one of our sources at $z$=7.15 clearly indicates the presence of non-thermal radiation, such ionized bubbles may not uniquely arise in this manner. We discuss the unique advantages of extending such challenging diagnostic studies with JWST.Comment: 11 pages, 7 figures, submitted to Ap

Mahi-mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes.

BackgroundMahi-mahi (Coryphaena hippurus) is a commercially and ecologically important fish species that is widely distributed in tropical and subtropical waters. Biological attributes and reproductive capacities of mahi-mahi make it a tractable model for experimental studies. In this study, life development of cultured mahi-mahi from the zygote stage to adult has been described.ResultsA comprehensive developmental table has been created reporting development as primarily detailed observations of morphology. Additionally, physiological, behavioral, and molecular landmarks have been described to significantly contribute in the understanding of mahi life development.ConclusionRemarkably, despite the vast difference in adult size, many developmental landmarks of mahi map quite closely onto the development and growth of Zebrafish and other warm-water, active Teleost fishes

Lyman-alpha Emission from a Luminous z=8.68 Galaxy: Implications for Galaxies as Tracers of Cosmic Reionization

We report the discovery of Lyman-alpha emission (Ly$\alpha$) in the bright galaxy EGSY-2008532660 (hereafter EGSY8p7) using the MOSFIRE spectrograph at the Keck Observatory. First reported by Roberts-Borsani et al. (2015), it was selected for spectroscopic observations because of its photometric redshift ($z_{phot}=8.57^{+0.22}_{-0.43}$), apparent brightness (H$_{160}=25.26\pm0.09$) and red Spitzer/IRAC [3.6]-[4.5] color indicative of contamination by strong oxygen emission in the [4.5] band. With a total integration of $\sim$4.3 hours, our data reveal an emission line at $\simeq$11776 {\AA} which we argue is likely Ly$\alpha$ at a redshift $z_{spec}=8.683^{+0.001}_{-0.004}$, in good agreement with the photometric estimate. The line was detected independently on two nights using different slit orientations and its detection significance is $\sim7.5\sigma$. An overlapping skyline contributes significantly to the uncertainty on the total line flux although the significance of the detected line is robust to a variety of skyline-masking procedures. By direct addition and a Gaussian fit, we estimate a 95\% confidence range of 1.0--2.5$\times10^{-17}$ erg s$^{-1}$ cm$^{-2}$, corresponding to a rest-frame equivalent width of 17--42 {\AA}. EGSY8p7 is the most distant galaxy confirmed spectroscopically to date, and the third luminous source in the EGS field beyond $z_{phot}\gtrsim7.5$ with detectable Ly$\alpha$ emission viewed at a time when the intergalactic medium is believed to be fairly neutral. Although the reionization process was probably patchy, we discuss whether luminous sources with prominent IRAC color excesses may harbor harder ionizing spectra than the dominant fainter population thereby creating earlier ionized bubbles. Further spectroscopic follow-up of such bright sources promises important insight into the early formation of galaxies.Comment: V3: ApJL accepted; 7 pages, 4 figures, 1 tabl

Combined shear/compression structural testing of asymmetric sandwich structures

Asymmetric sandwich technology can be applied in the design of lightweight, non-pressurized aeronautical structures such as those of helicopters. A test rig of asymmetric sandwich structures subjected to compression/shear loads was designed, validated, and set up. It conforms to the standard certification procedure for composite aeronautical structures set out in the “test pyramid”, a multiscale approach. The static tests until failure showed asymmetric sandwich structures to be extremely resistant, which, in the case of the tested specimen shape, were characterized by the absence of buckling and failure compressive strains up to 10,000 μ strains. Specimens impacted with perforation damage were also tested, enabling the original phenomenon of crack propagation to be observed step-by-step. The results of the completed tests thus enable the concept to be validated, and justify the possibility of creating a much larger machine to overcome the drawbacks linked to the use of small specimens

Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative.

Enrollment of children into pediatric clinical trials remains challenging. More effective strategies to improve recruitment of children into trials are needed. This study used in-depth qualitative interviews with parents who were approached to enroll their children in a clinical trial in order to gain an understanding of the barriers to pediatric clinical trial participation. Twenty-four parents whose children had been offered the opportunity to participate in a clinical trial were interviewed: 19 whose children had participated in at least 1 clinical trial and 5 who had declined participation in any trial. Each study aspect, from the initial explanation of the study to the end of the study, can affect the willingness of parents to consent to the proposed study and future studies. Establishing trust, appropriate timing, a transparent discussion of risks and benefits oriented to the layperson, and providing motivation for children to participate were key factors that impacted parents' decisions. In order for clinical trial accrual to be successful, parents' priorities and considerations must be a central focus, beginning with initial trial design. The recommendations from the parents who participated in this study can be used to support budget allocations that ensure adequate training of study staff and improved staffing on nights and weekends. Studies of parent responses in outpatient settings and additional inpatient settings will provide valuable information on the consent process from the child's and parent's perspectives. Further studies are needed to explore whether implementation of such strategies will result in improved recruitment for pediatric clinical trials

Doublethink and scale mismatch polarize policies for an invasive tree

Mismatches between invasive species management policies and ecological knowledge can lead to profound societal consequences. For this reason, natural resource agencies have adopted the scientifically-based density-impact invasive species curve to guide invasive species management. We use the density-impact model to evaluate how well management policies for a native invader (Juniperus virginiana) match scientific guidelines. Juniperus virginiana invasion is causing a sub-continental regime shift from grasslands to woodlands in central North America, and its impacts span collapses in endemic diversity, heightened wildfire risk, and crashes in grazing land profitability. We (1) use land cover data to identify the stage of Juniperus virginiana invasion for three ecoregions within Nebraska, USA, (2) determine the range of invasion stages at individual land parcel extents within each ecoregion based on the density-impact model, and (3) determine policy alignment and mismatches relative to the density-impact model in order to assess their potential to meet sustainability targets and avoid societal impacts as Juniperus virginiana abundance increases. We found that nearly all policies evidenced doublethink and policy-ecology mismatches, for instance, promoting spread of Juniperus virginiana regardless of invasion stage while simultaneously managing it as a native invader in the same ecoregion. Like other invasive species, theory and literature for this native invader indicate that the consequences of invasion are unlikely to be prevented if policies fail to prioritize management at incipient invasion stages. Theory suggests a more realistic approach would be to align policy with the stage of invasion at local and ecoregion management scales. There is a need for scientists, policy makers, and ecosystem managers to move past ideologies governing native versus non-native invader classification and toward a framework that accounts for the uniqueness of native species invasions, their anthropogenic drivers, and their impacts on ecosystem services

Molecular Basis of Lysosomal Enzyme Recognition: Three-Dimensional Structure of the Cation-Dependent Mannose 6-Phosphate Receptor

AbstractTargeting of newly synthesized lysosomal hydrolases to the lysosome is mediated by the cation-dependent mannose 6-phosphate receptor (CD-MPR) and the insulin-like growth factor II/cation-independent mannose 6-phosphate receptor (IGF-II/CI-MPR). The two receptors, which share sequence similarities, constitute the P-type family of animal lectins. We now report the three-dimensional structure of a glycosylation-deficient, yet fully functional form of the extracytoplasmic domain of the bovine CD-MPR (residues 3–154) complexed with mannose 6-phosphate at 1.8 Å resolution. The extracytoplasmic domain of the CD-MPR crystallizes as a dimer, and each monomer folds into a nine-stranded flattened β barrel, which bears a striking resemblance to avidin. The distance of 40 Å between the two ligand-binding sites of the dimer provides a structural basis for the observed differences in binding affinity exhibited by the CD-MPR toward various lysosomal enzymes

Heaviness, health and happiness: a cross-sectional study of 163 066 UK Biobank participants

<b>Background</b><p></p> Obesity is known to increase the risk of many diseases and reduce overall quality of life. This study examines the relationship with self-reported health (SRH) and happiness.<p></p> <b>Methods</b> <p></p>We conducted a cross-sectional study of the 163 066 UK Biobank participants who completed the happiness rating. The association between adiposity and SRH and happiness was examined using logistic regression. SRH was defined as good (excellent, good), or poor (fair, poor). Self-reported happiness was defined as happy (extremely, very, moderately) or unhappy (moderately, very, extremely). <p></p> <b>Results</b> <p></p>Poor health was reported by 44 457 (27.3%) participants. The adjusted ORs for poor health were 3.86, 2.92, 2.60 and 6.41 for the highest, compared with lowest, deciles of Body Mass Index, waist circumference, waist to hip ratio and body fat percent, respectively. The associations were stronger in men (p<0.001). Overall, 7511 (4.6%) participants felt unhappy, and only class III obese participants were more likely to feel unhappy (adjusted OR 1.33, 95% CI 1.15 to 1.53, p<0.001) but the associations differed by sex (p<0.001). Among women, there was a significant association between unhappiness and all levels of obesity. By contrast, only class III obese men had significantly increased risk and overweight and class I obese men were less likely to be unhappy. <p></p> <b>Conclusions</b><p></p>Obesity impacts adversely on happiness as well as health, but the association with unhappiness disappeared after adjustment for self-reported health, indicating this may be mediated by health. Compared with obese men, obese women are less likely to report poor health, but more likely to feel unhappy. <p></p&gt

Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative.

Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to recruitment of pediatric patients, but little is known regarding the specific barriers that limit pediatric providers from participating in and referring their patients to clinical trials. We conducted an online survey of pediatric providers from a wide variety of practice types across the United States to evaluate their attitudes and awareness of pediatric clinical trials. Using a 4-point Likert scale, providers described their perception of potential barriers to their practice serving as a site for pediatric clinical trials. Of the 136 providers surveyed, 52/136 (38%) had previously referred a pediatric patient to a trial, and only 17/136 (12%) had ever been an investigator for a pediatric trial. Lack of awareness of existing pediatric trials was a major barrier to patient referral by providers, in addition to consideration of trial risks, distance to the site, and time needed to discuss trial participation with parents. Overall, providers perceived greater challenges related to parental concerns and parent or child logistical barriers than study implementation and ethics or regulatory barriers as barriers to their practice serving as a trial site. Providers who had previously been an investigator for a pediatric trial were less likely to be concerned with potential barriers than non-investigators. Understanding the barriers that limit pediatric providers from collaboration or inhibit their participation is key to designing effective interventions to optimize pediatric trial participation