How the weights associated with prognostic and prescriptive variables combine with a patient's values to contribute to the calculation of the patient's Personalized Advantage Index.

<p>LOO  =  Leave One Out. ADM  =  Antidepressant Medication. HRSD  =  Hamilton Rating Scale for Depression.</p>a<p> =  Prognostic variable.</p>b<p> =  Prescriptive variable.</p>c<p> =  See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083875#pone-0083875-t004" target="_blank">Table 4</a>.</p

Paroxetine vs. Placebo Comparison of Symptom Measure and Neuroticism Change.

<p>Paroxetine vs. Placebo Comparison of Symptom Measure and Neuroticism Change.</p

Frequency histogram showing predicted end-HRSD scores for each patient in their Optimal and their Non-Optimal treatment, as indicated by the treatment selection algorithm.

<p>Frequency histogram showing predicted end-HRSD scores for each patient in their Optimal and their Non-Optimal treatment, as indicated by the treatment selection algorithm.</p

Frequency histogram showing Personalized Advantage Index (PAI) scores for all patients in the sample.

<p>Frequency histogram showing Personalized Advantage Index (PAI) scores for all patients in the sample.</p

Intake and Week 8 Scores on Symptom Measures, as Percentage of Possible Maximum (POMP) Scores.

<p>Intake and Week 8 Scores on Symptom Measures, as Percentage of Possible Maximum (POMP) Scores.</p

The treatment (Tx) main effect and interactions of Tx with the prescriptive variables.

<p>LOO  =  Leave One Out. CBT  =  Cognitive Behavioral Therapy. ADM  =  Antidepressant Medication. Tx  =  Treatment. HRSD  =  Hamilton Rating Scale for Depression.</p>a<p> =  See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083875#pone-0083875-t004" target="_blank">Table 4</a>.</p

Descriptive statistics for baseline variables.

<p>ADM  =  Antidepressant Medication. CBT  =  Cognitive Behavioral Therapy. HRSD  =  Hamilton Rating Scale for Depression.</p><p>^a =  Capped at 2; sample breakdown for number prior medications: 0 = 52% (55% in ADM, 46% in CBT), 1 = 24% (21% in ADM, 30% in CBT), 2 or more  = 24% (24% in ADM, 24% in CBT).</p

Paroxetine vs. Placebo Main Effects for Depression, Anxiety, and Subscales.

<p>Paroxetine vs. Placebo Main Effects for Depression, Anxiety, and Subscales.</p

Comparison of mean end-HRSD scores for patients randomly assigned to their Optimal treatment versus those assigned to their Non-Optimal treatment.

<p>The left side gives the results for the full sample. The right side includes only patients for whom the algorithm predicted a clinically significant advantage on the PAI of ≥3.</p

How the estimates from Tables 2 and 3 combine to produce a patient's estimated end-HRSD scores in CBT and ADM, respectively, and the PAI.

<p>Tx  =  Treatment. CBT  =  Cognitive Behavioral Therapy. ADM  =  Antidepressant Medication. HRSD  =  Hamilton Rating Scale for Depression. PAI  =  Personalized Advantage Index; the difference between the predictions for CBT and ADM, in end-HRSD units.</p>a<p> =  The square of the model output.</p