Developing Diplomats: Comparing Form and Culture Across Diplomatic Services, PRP 194

This study is a detailed and focused effort to broaden how we understand and conceptualize the recruitment, training, and development of professional diplomats in the twenty-first century. The goal is not to criticize processes in different countries, but to create a common foundation for comparing, learning, and even integrating training and career development models across nations.Public Affair

An overview of recent advances of the catalytic selective oxidation of ethane to oxygenates

The selective partial oxidation of short chain alkanes is a key challenge within catalysis research. Direct ethane oxidation to oxygenates is a difficult aim, but potentially rewarding, and it could lead to a paradigm shift in the supply chain of several bulk chemicals. Unfortunately, low C–H bond reactivity and kinetically labile products are just some reasons affecting the development and commercialisation of such processes. Research into direct ethane oxidation is therefore disparate, with approaches ranging from oxidation in the gas phase at high temperatures to enzyme catalysed hydroxylation under ambient conditions. Furthermore, in overcoming the barrier posed by the chemically inert C–H bond a range of oxidants have been utilised. Despite years of research, this remains an intriguing topic from both academic and commercial perspectives. Herein we describe some recent developments within the field of catalytic ethane oxidation focusing on the formation of oxygenated products, whilst addressing the key challenges which are still to be overcome

Correction to: Solvent free synthesis of PdZn/TiO2 catalysts for the hydrogenation of CO2 to methanol

The article Solvent Free Synthesis of PdZn/TiO2 Catalysts for the Hydrogenation of CO2 to Methanol by Hasliza Bahruji, Jonathan Ruiz Esquius, Michael Bowker, Graham Hutchings, Robert D. Armstrong, Wilm Jones was originally published Online First without open access. After publication in volume 61, issue 3–4, pages 144–153, the author decided to opt for Open Choice and to make the article an open access publication. Therefore, the copyright of the article has been changed to ©The Author(s) 2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Preparation of Solid Solution and Layered IrO _x-Ni(OH)₂Oxygen Evolution Catalysts:Toward Optimizing Iridium Efficiency for OER

Minimizing iridium loading in oxygen evolution reaction (OER) catalysts, without impairing electrocatalytic activity and stability is crucial to reduce the cost of water electrolysis. In this work, two Ir0.5Ni0.5Ox mixed oxide catalysts with layered and solid solution morphologies were prepared by modifying a facile hydrothermal methodology. The catalytic OER activity and stability of the Ir-Ni catalyst with a homogeneous distribution (IrNi-HD) was seriously compromised compared to pure IrOx due to the high concentration of surface nickel prone to corrosion under reaction conditions. However, the design of layered IrOx-Ni(OH)x (IrNi-LY) with Ir at the exposed surface allowed a 50% reduction in the molar concentration of the precious metal on the electrode compared to IrOx without impairing the catalytic activity or stability. As a result, IrNi-LY outperformed IrOx in activity when normalized to the Ir mass. </p

Quantification of Residual Stresses in Electron Beam Welded Fracture Mechanics Specimens

Residual stress measurements have been made in a range of electron beam welded samples to study how the weld induced residual stresses redistributed during fabrication of compact tension, C(T), specimens. The samples were manufactured from Type 316H stainless steel in the ex-service material condition and in material which had been preconditioned by inducing 8% plastic strain. Measurements made using neutron diffraction, slitting and the contour method were generally in good agreement and showed residual stress components of up to three times the base material's yield strength existed in the samples. When sectioning a sample to perform the contour method, large elastic deformations occurred at the cut tip due to the large residual stresses present. A correction was applied to the measured surface displacements to account for this deformation. Neutron diffraction measurements were made at various stages of the fabrication process, which showed significant stress redistribution occurred as the welded samples were machined into C(T) specimens. However the tensile stresses near the crack tip of the C(T) specimens remained large and could significantly influence subsequent crack growth tests

Evidence of blood stage efficacy with a virosomal malaria vaccine in a Phase IIa clinical trial

Background Previous research indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine. This trial was the first to combine two existing vaccination strategies to produce a vaccine that induces immune responses to both the pre-erythrocytic and blood stages of the P. falciparum life cycle. Methods This was a Phase I/IIa study of a new combination malaria vaccine FFM ME-TRAP+PEV3A. PEV3A includes peptides from both the pre-erythrocytic circumsporozoite protein and the blood-stage antigen AMA-1. This study was conducted at the Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, UK. The participants were healthy, malaria naïve volunteers, from Oxford. The interventions were vaccination with PEV3A alone, or PEV3A+FFM ME-TRAP. The main outcome measure was protection from malaria in a sporozoite challenge model. Other outcomes included measures of parasite specific immune responses induced by either vaccine; and safety, assessed by collection of adverse event data. Results We observed evidence of blood stage immunity in PEV3A vaccinated volunteers, but no volunteers were completely protected from malaria. PEV3A induced high antibody titres, and antibodies bound parasites in immunofluorescence assays. Moreover, we observed boosting of the vaccine-induced immune response by sporozoite challenge. Immune responses induced by FFM ME-TRAP were unexpectedly low. The vaccines were safe, with comparable side effect profiles to previous trials. Although there was no sterile protection two major observations support an effect of the vaccine-induced response on blood stage parasites: (i) Lower rates of parasite growth were observed in volunteers vaccinated with PEV3A compared to unvaccinated controls (p = 0.012), and this was reflected in the PCR results from PEV3A vaccinated volunteers. These showed early control of parasitaemia by some volunteers in this group. One volunteer, who received PEV3A alone, was diagnosed very late, on day 20 compared to an average of 11.8 days in unvaccinated controls. (ii). Morphologically abnormal parasites were present in the blood of all (n = 24) PEV3A vaccinated volunteers, and in only 2/6 controls (p = 0.001). We describe evidence of vaccine-induced blood stage efficacy for the first time in a sporozoite challenge study