294 research outputs found

    Organizational Innovation in Russian Agriculture: The Emergence of "New Agricultural Operators" and Its Consequences

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    After almost a decade of downsizing, Russian agriculture has been steadily growing since the end of 90's against the background of deep organizational changes and innovations. The traditional collective farming segment is the key target and subject of innovations. Outside investors and operators have acquired control over farm assets from the primary nominal owners and possessors. As a result, exceptionally large commercial farm operations - "agroholdings" - are being created. Both inside and outside innovators are introducing organizational changes such as vertical integration, custom and contract farming, land leasing, machinery sharing and others. The paper discusses size, scope and character of the ongoing innovations and their short and long-term consequences.agroholdings, contract and custom farming, new agricultural operators, integration, Industrial Organization,

    Investigating the impact of asymmetric macular sensitivity on visual acuity chart reading in choroideraemia

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    Introduction: Degeneration in choroideraemia, unlike typical centripetal photoreceptor degenerations, is centred temporal to the fovea. Once the fovea is affected, the nasal visual field (temporal retina) is relatively spared, and the preferred retinal locus shifts temporally. Therefore, when reading left to right, only the right eye reads into a scotoma. We investigate how this unique property affects the ability to read an eye chart. Methods: Standard‐ and low‐luminance visual acuity (VA) for right and left eyes were measured with the Early Treatment of Diabetic Retinopathy Study (ETDRS) chart. Letters in each line were labelled by column position. The numbers of letter errors for each position across the whole chart were summed to produce total column error scores for each participant. Macular sensitivity was assessed using microperimetry. Central sensitivity asymmetry was determined by the temporal‐versus‐nasal central macular difference and subsequently correlated to a weighted ETDRS column error score. Healthy volunteers and participants with X‐linked retinitis pigmentosa GTPase regulator associated retinitis pigmentosa (RPGR‐RP) were used as controls. Results: Thirty‐nine choroideraemia participants (median age 44.9 years [IQR 35.7–53.5]), 23 RPGR‐RP participants (median age 30.8 years [IQR 26.5–40.5]) and 35 healthy controls (median age 23.8 years [IQR 20.3–29.0]) were examined. In choroideraemia, standard VA in the right eye showed significantly greater ETDRS column errors on the temporal side compared with the nasal side (p = 0.002). This significantly correlated with greater asymmetry in temporal‐versus‐nasal central macular sensitivity (p = 0.04). No significant patterns in ETDRS column errors or central macular sensitivity were seen in the choroideraemia left eyes, nor in RPGR‐RP and control eyes. Conclusion: Difficulty in tracking across lines during ETDRS VA testing may cause excess errors independent of true VA. VA assessment with single‐letter optotype systems may be more suitable, particularly for patients with choroideraemia, and potentially other retinal diseases with asymmetric central macular sensitivity or large central scotomas including geographic atrophy

    The effect of volume change and stack pressure on solid‐state battery cathodes

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    Solid-state lithium batteries may provide increased energy density and improved safety compared with Li-ion technology. However, in a solid-state composite cathode, mechanical degradation due to repeated cathode volume changes during cycling may occur, which may be partially mitigated by applying a significant, but often impractical, uniaxial stack pressure. Herein, we compare the behavior of composite electrodes based on Li4Ti5O12 (LTO) (negligible volume change) and Nb2O5 (+4% expansion) cycled at different stack pressures. The initial LTO capacity and retention are not affected by pressure but for Nb2O5, they are significantly lower when a stack pressure of <2 MPa is applied, due to inter-particle cracking and solid-solid contact loss because of cyclic volume changes. This work confirms the importance of cathode mechanical stability and the stack pressures for long-term cyclability for solid-state batteries. This suggests that low volume-change cathode materials or a proper buffer layer are required for solid-state batteries, especially at low stack pressures

    Reflecting on loss in Papua New Guinea

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    This article takes up the conundrum of conducting anthropological fieldwork with people who claim that they have 'lost their culture,' as is the case with Suau people in the Massim region of Papua New Guinea. But rather than claiming culture loss as a process of dispossession, Suau claim it as a consequence of their own attempts to engage with colonial interests. Suau appear to have responded to missionization and their close proximity to the colonial-era capital by jettisoning many of the practices characteristic of Massim societies, now identified as 'kastom.' The rejection of kastom in order to facilitate their relations with Europeans during colonialism, followed by the mourning for kastom after independence, both invite consideration of a kind of reflexivity that requires action based on the presumed perspective of another

    Platelet depletion in experimental myocardial infarction

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    Accumulation of platelets in the microvasculature after acute myocardial ischemia may exacerbate tissue injury through the formation of microthrombi and by the release of vasoactive substances. To assess the role of platelets in myocardial ischemic injury and infarction, circulating platelets were reduced by 94±2% (mean±S.E.M.) with sheep antiserum to canine platelets. Regional myocardial ischemia was produced by occlusion of the left circumflex coronary artery (LCCA) for 90 min followed by reperfusion for 5 hours. Infarct size did not differ significantly between antiplatelet serum and nonimmune serum groups: 36±8 vs. 43±4% of the area at risk, determined by a post-mortem dual staining technique (p>0.05). A second occlusion-reperfusion control group, sacrificed at 24 hours, did not differ from 5 hr reperfused groups with regard to infarct size. Coronary sinus thromboxane B 2 (TXB 2 ) concentrations were not altered significantly by platelet depletion. Histopathologic examination confirmed the presence of necrosis in the infarcted myocardium and revealed substantial leukocytic infiltration in both groups. The results suggest that circulating platelets are not required for the full expression of myocardial ischemic injury resulting from temporary coronary artery occlusion followed by reperfusion.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41747/1/395_2005_Article_BF01907903.pd

    Capability and Quality of Products in Relation to Sustainability: A Model for a Sustainable Subcontract Electronics Manufacturing Companies

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    The study aimed to determine the relationship of capability and quality of products in relation to sustainability of subcontract electronics manufacturing companies in the Philippines, Indonesia, Malaysia, Singapore, Taiwan, Thailand, and Vietnam. The respondents’ profile such as plant location and years of operations were considered as moderator variables. Data from 46 subcontract electronics manufacturing companies were analyzed using descriptive and inferential statistics.  Furthermore, bootstrapping procedure was used due to the limited number of electronics subcontract manufacturing companies who participated in this study. The study shows that the subcontract electronics manufacturing companies were all capable in terms of the control processes and packages classification; and highly capable in terms of production capacity. The quality of products in terms of goods and services was all perceived to be good.  Company respondents were perceived to be high in economic and social sustainability and very high in terms of environmental sustainability.  Further results revealed that packaging, production capacity, consumer specification, and reliability testing are significant predictors of the economic sustainability. It also shows that control processes, reliability testing, and inspection and quality were significant predictors of social sustainability. Customer specification and reliability testing are significant predictors of environmental sustainability.  Overall, the result showed that production capacity, consumer specification, and inspection and quality are the significant predictors of the sustainability.  CAPAQUALISUS model for sustainable subcontract electronics manufacturing companies was developed from this study

    Evaluation of Strategic Planning in HEIs Using Contex, Input, Process, Product (CIPP) Model: Basis for an Enhanced Model

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    This study aimed to evaluate and improve the prevailing strategic planning process of selected Higher Education Institutions (HEIs) using the Context, Input, Process and Product (CIPP) by Daniel L. Stufflebeam in 1966. The study utilized quantitative techniques with 644 respondents composed of administrators, associates and assistants in administration, faculty and staff of selected higher education institutions (HEIs). Six HEIs were selected to represent each type of institution under the vertical typology of the Commission on Higher Education (CHED), namely: autonomous, deregulated, and regulated. In each category, two were selected to represent the group of HEIs they belong: two HEIs which were granted Autonomous Status, two HEIs that were given Deregulated Status, and two HEIs with Regulated Status. The geographical location was considered in choosing the HEIs. The evaluation results emphasize that the performance and degree of implementation of both autonomous and deregulated status are of the same range in most of the aspects that were subjected to evaluation. It is suggesting that deregulated HEIs performance is leaning towards being autonomous than of being at the lower end of the scale, except for financial capability where the capacities of deregulated HEIs is closer that of regulated HEIs. Further results revealed that universities and colleges differ in the degree of implementation on the monitoring of finance. Based on the results, a proposed program to enhance strategic planning process model was developed

    Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease)

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    The neuronal ceroid lipofuscinoses are a group of lysosomal storage disorders that comprise the most common, genetically heterogeneous, fatal neurodegenerative disorders of children. They are characterised by childhood onset, visual failure, epileptic seizures, psychomotor retardation and dementia. CLN3 disease, also known as Batten disease, is caused by autosomal recessive mutations in the CLN3 gene, 80–85% of which are a ~1 kb deletion. Currently no treatments exist, and after much suffering, the disease inevitably results in premature death. The aim of this study was to generate a zebrafish model of CLN3 disease using antisense morpholino injection, and characterise the pathological and functional consequences of Cln3 deficiency, thereby providing a tool for future drug discovery. The model was shown to faithfully recapitulate the pathological signs of CLN3 disease, including reduced survival, neuronal loss, retinopathy, axonopathy, loss of motor function, lysosomal storage of subunit c of mitochondrial ATP synthase, and epileptic seizures, albeit with an earlier onset and faster progression than the human disease. Our study provides proof of principle that the advantages of the zebrafish over other model systems can be utilised to further our understanding of the pathogenesis of CLN3 disease and accelerate drug discovery
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