Web based lecture technologies: blurring the boundaries between face to face and distance learning

Web based lecture technologies (WBLT) have gained popularity amongst universities in Australia as a tool for delivering lecture recordings to students in close to real time. This paper reports on a selection of results from a larger research project investigating the impact of WBLT on teaching and learning. Results show that while staff see the advantages for external students, they question the extent to which these advantages apply to internal students. In contrast both cohorts of students were positive about the benefits of the technologies for their learning and they adopted similar strategies for their use. With the help of other technologies, some external students and staff even found WBLT useful for fostering communication between internal and external students. As such, while the traditional boundary between internal and external students seems to remain for some staff, students seem to find the boundary much less clear

High-cut harvesting of maize stover and genotype choice can provide improved feed for ruminants and stubble for conservation agriculture

In smallholder crop–livestock systems where maize (Zea mays L.) is a staple cereal, the stover is usually an important but low-quality ruminant feed. Maize stover has various competing uses, and optimal allocation of stover, particularly for forage and mulch, is essential for improving whole-farm productivity and sustainability. Knowledge that feed quality increases with height in maize stover provides opportunities. An experiment investigated the effects of a high cutting height of stover at grain harvest (cut at two internodes below the lowest ear) on the yields and feed quality of the upper and lower stover (stubble) fractions. Measurements were made on six maize genotypes at two sites during two cropping seasons in Ethiopia. The upper stover fraction (USF) on average comprised 674 g kg–1 of the entire stover and was also substantially higher (P <.001) than the lower stover fraction (LSF) in in vitro dry matter digestibility (527 vs. 450 g kg−1 dry matter [DM]) and total N concentrations (8.8 vs. 6.2 g kg−1 DM) and was lower in fiber. Stems (including leaf sheath and tassel), husks (including shank), and leaf blade comprised 484, 310, and 206 g kg−1 of the USF, respectively. Yields and feed quality of stover varied among genotypes and environments. Use of an USF can provide a feedstuff of increased nutritional quality for ruminants, but the efficacy of the LSF for mulch requires investigation. In conclusion, a simple management change to harvest maize stover at higher stubble height combined with use of appropriate genotypes can provide higher-quality feed while leaving stubble for conservation agriculture

Variations in seed and post-harvest residue yields and residues quality of common bean ( Phaseolus vulgaris L.) as a ruminant feedstuff

Common bean is widely grown as a food legume and the post-harvest crop residues (CR) (i.e. haulm + pod wall (HPW)) are valuable as ruminant feedstuffs. The yields and constituents indicative of nutritive value for ruminants of the HPW from a wide range of common bean genotypes (G) were examined at 4 trial sites in Ethiopia during the 2013 main cropping season to assess the extent of genetic variation among G for simultaneous improvement of both HPW attributes and seed yield. Attributes measured were seed and HPW yields and the amounts of the morphological components, their concentrations of total nitrogen (N), neutral detergent fibre (aNDFom) and acid detergent fibre (ADFom), and the dry matter digestibility (DMD). The constituents were measured using near infrared spectroscopy (NIRS) and calibrations based on a large set of reference tropical forages and CR (including common bean), and were validated against other CR reference samples. These CR quality attributes were very well predicted with R2v and RPDv ranging from 0.90 to 0.98 and 3.13–7.36, respectively. There was considerable variation in yields of HPW and seed, and in the proportions and attributes of the HPW fractions among the common bean G. Trial site means for yields of HPW and seed ranged from 0.74 to 2.54 t/ha and 0.79–2.62 t/ha, respectively while for N, aNDFom and ADFom concentrations and DMD of HPW ranged from 7.7 to 11.4 g/kg DM, 648–739 g/kg DM, 502–585 g/kg DM, and 467–570 g/kg DM, respectively. Environment (E), as represented by site, generally affected the yields of HPW and seed (P < 0.001) and nutritive value of the HPW fractions (P < 0.05) as feedstuffs. Seed yield was positively correlated with HPW yield both within and across trial sites (r = 0.92; P < 0.0001), but in general seed yield was not related to the N concentration. Across all sites, seed yield was positively correlated (r = 0.68; P < 0.0001) with haulm DMD. Although this correlation may be due to variation associated with E rather than G, it is nevertheless important in that selection for higher seed yield is likely to also increase metabolisable energy (ME) content of the HPW. There were G x E interaction effects on yields of HPW (P < 0.0001) and seed (P = 0.011), but these were generally less important than E effects which explained 52–58% of the variation. In conclusion the study demonstrated that it is possible to identify genotypes such as ECAB0081 which combine high yields of both seed and HPW, and with HPW attributes which improve their quality as ruminant feedstuffs

Henry Jackson Society: The Threat to British Democracy and Society Caused by Security Think Tanks: Full Report

This report explores the impact that security think tanks such as the Henry Jackson Society (HJS) are having on British democracy and societal cohesion. It highlights links between such groups and the British and international far Right which combine with patterns of divisive and agendadriven reports based in impoverished methodologies to shape UK policy and political discourse for the worse. Such groups have caused concern amongst numerous equalities, community, and faith groups and are cited as enabling and encouraging Islamophobia and racism, facilitating far Right mobilisation, and pushing successive UK governments towards policy positions that damage societal cohesion. This report brings together open-source articles, reports, and public instances of events to document the problematic work being carried out by these security-focused think tanks and map the impact that they have had on British society. Whilst the report is particularly concerned by the on-going work of HJS, the findings are applicable to a broad network of private and publicly funded security organisations that benefit financially from the on-going War on Terror, and which routinely publish poorly researched work, thereby encouraging hostile attitudes and repressive policies against Muslims and minorities across the U

A core outcome set for localised prostate cancer effectiveness trials

Objective: To develop a core outcome set (COS) applicable for effectiveness trials of all interventions for localised prostate cancer. Background: Many treatments exist for localised prostate cancer, although it is unclear which offers the optimal therapeutic ratio. This is confounded by inconsistencies in the selection, definition, measurement and reporting of outcomes in clinical trials. Subjects and methods: A list of 79 outcomes was derived from a systematic review of published localised prostate cancer effectiveness studies and semi-structured interviews with 15 prostate cancer patients. A two-stage consensus process involving 118 patients and 56 international healthcare professionals (HCPs) (cancer specialist nurses, urological surgeons and oncologists) was undertaken, consisting of a three-round Delphi survey followed by a face-to-face consensus panel meeting of 13 HCPs and 8 patients. Results: The final COS included 19 outcomes. Twelve apply to all interventions: death from prostate cancer, death from any cause, local disease recurrence, distant disease recurrence/metastases, disease progression, need for salvage therapy, overall quality of life, stress urinary incontinence, urinary function, bowel function, faecal incontinence, sexual function. Seven were intervention-specific: perioperative deaths (surgery), positive surgical margin (surgery), thromboembolic disease (surgery), bothersome or symptomatic urethral or anastomotic stricture (surgery), need for curative treatment (active surveillance), treatment failure (ablative therapy), and side effects of hormonal therapy (hormone therapy). The UK-centric participants may limit the generalisability to other countries, but trialists should reason why the COS would not be applicable. The default position should not be that a COS developed in one country will automatically not be applicable elsewhere. Conclusion: We have established a COS for trials of effectiveness in localised prostate cancer, applicable across all interventions which should be measured in all localised prostate cancer effectiveness trials

Ladies in waiting: the timeliness of first trimester services in New Zealand

<p>Abstract</p> <p>Background</p> <p>Termination of pregnancy (TOP) services are a core service in New Zealand. However, compared to other developed countries, TOP services are accessed significantly later in the first trimester, increasing the risk for complications. The aim of this study is to examine the timeliness of access to first trimester TOP services and establish the length of delay between different points in the care pathway for these services.</p> <p>Methodology</p> <p>Data were collected from all patients attending nine TOP clinics around the country between February and May 2009 (N = 2950). Patient records were audited to determine the timeline between the first point of entry to the health system to the date of termination. In addition, women were invited to fill out a questionnaire to identify personal level factors affecting access to services (N = 1086, response rate = 36.8%).</p> <p>Results</p> <p>Women waited an average of almost 25 days between the date of the first visit with the referring doctor and the date of their termination procedure. There was a delay of 10 days between the first visit with the referring doctor and the date that the appointment for the procedure was booked, and a further 10 days delay between the date the appointment was booked and the first appointment date. Over half of the women in this study had their pregnancy terminated at ten weeks or above.</p> <p>Conclusion</p> <p>Women in New Zealand are subject to a lengthy delay while seeking TOP services. Efforts should be made by TOP clinics as well as referring doctors to reduce the waiting times for this service.</p

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p&lt;0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (&lt;1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (&lt;1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline