Atlántico digital : logros y desafíos : procesos para una ciudadanía digital

Atlántico Digital: De este lado de la frontera de la comunicación -- Las redes de fibra óptica en el Atlántico: 400 kilómetros de desarrollo -- Retos digitales: a propósito de Gobierno en Línea en el Atlántico -- Nuevas Tecnologías y Políticas de la Representación: reduciendo la brecha cultural.Editorial Universidad del Nort

Kwapa: Gente del río. Estrategias transmedia de impacto social

PAP Alter Código produce materiales de interacción audiovisual que se organizan en un universo transmedia, trabaja con personas de todas las edades, su meta es difundir representaciones no estigmatizantes de grupos socialmente desfavorecidos, además de compartir esta visión a todo aquel que colabore en el proyecto. En la temporada de verano 2023, el equipo Alter CÓDIGO continuó con el desarrollo del videojuego “A la orilla del río”, para ello la organización del trabajo se dividió en múltiples áreas tanto como comunitarias como digitales para dar una mayor profundidad al producto. Los avances más significativos van desde una versión más actualizada del guion, storyboards, una primera animación, un demo, este último de lo que sería el gameplay, y un minijuego. Asimismo, se muestra la vinculación comunitaria e impacto social que se logró con el desarrollo de los talleres de intervención fotográfica con niños acerca de su territorio. Paralelamente se aborda la creación de redes sociales y página web para la difusión del proyecto por fuera del PAP. En los dos meses de trabajo se cumplieron con los ideales del Proyecto de Aplicación Profesional y se logró una difusión transmedia. A pesar de que el proyecto aún no llega a su finalización, los avances y el alcance superaron las metas que se otorgaron al inicio de la temporada.ITESO, A.C

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI &lt;18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For school&#x2;aged children and adolescents, we report thinness (BMI &lt;2 SD below the median of the WHO growth reference) and obesity (BMI &gt;2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 12

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 12, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR), Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTAG), Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kleber Ramírez (UPTM), Mérida – Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (C.A.B.B.O.P.P), Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE), Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia - Venezuela, Centro de Investigaciones Internacionales SAS (CIN), Antioquia - Colombia.y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso

Calidad del agua subterránea para el riego en el Oasis de Pica, norte de Chile

ABSTRACT Farmers from the Pica Oasis localities, foothills of northern Chile, take advantage of groundwater at different depths in the irrigation of citrus crops, tropical fruits and vegetables. In order to establish a monitoring network and provide recommendations to the irrigators, the physicochemical properties of these waters were characterized, their annual temporal behavior and their quality for irrigation was determined, as well as to interpret factors that affect the composition. 29 wells at three depths (deep, intermediate and superficial aquifer) were managed for the network and the temperature, CE and pH were recorded in four campaigns between 2016 and 2017. The parameters quantified at <0.45 μm were TDS, major ions, nitrate, trace elements Cr-Mn-Fe-Co-Ni-Cu-Zn- Mo-Al-Cd-Pb-Hg-Li-Ba-B-As and the indicators %Na, SSP, SAR, RCS and PS. There are spatial variations, but not temporary, of the quality of the thermal groundwater, neutral to slightly alkaline. The vast majority are waters suitable for irrigation according to CE, RAS and CSR and there is no risk from metals and metalloids; except for% Na, PSS, SP, boron and lithium (citrus). The deep aquifer (80-100 m) has fresh waters of low EC, bicarbonated and / or sulphated sodium, but the level of% Na and PSS affects the soil; the intermediate (24-39 m) has fresh and brackish water, sulphated sodium and% Na, PSS and harmful SP. The surface aquifer (17-21 m) contains higher salinity (brackish), sodium-calcium and is distributed in the boundary between sulfated bicarbonated or sulphated chloridated, are in breach of regulations for chloride, sulfate and nitrate. The increase of dissolved ions in the surface aquifer is attributed to the dissolution of sulphated by alluvium in the area, bad practices in irrigation-fertilization processes and the aridity condition.RESUMEN Agricultores de las localidades del Oasis de Pica, precordillera del norte de Chile, aprovechan las aguas subterráneas a distintas profundidades en el riego de cultivos cítricos, frutos tropicales y verduras. Con el objeto de establecer una red de monitoreo y entregar recomendaciones a los regantes, se caracterizaron las propiedades fisicoquímicas de estas aguas, su comportamiento temporal anual y se determinó su calidad para riego, además de interpretar factores que inciden en su composición. Se gestionaron para la red 29 pozos a tres profundidades (acuífero profundo, intermedio y superficial) y se registró la temperatura, CE y pH en cuatro campañas entre 2016 y 2017. Los parámetros cuantificados a < 0,45 µm fueron STD, iones mayoritarios, nitrato, elementos traza Cr-Mn-Fe- Co-Ni-Cu-Zn-Mo-Al-Cd-Pb-Hg-Li-Ba-B-As y los indicadores agronómicos % Na, PSS, RAS, CSR y PS. Se observan diferencias espaciales, pero no temporales de la calidad de las aguas subterráneas termales, neutras a levemente alcalinas. La gran mayoría son aguas adecuadas para el riego de acuerdo a CE, RAS y CSR, y no existe riesgo por metales y metaloides; excepto por % Na, PSS, SP, boro y litio (cítricos) de origen natural. El acuífero profundo (80-100 m) posee aguas dulces de baja CE, bicarbonatadas y/o sulfatadas sódicas, pero el nivel de % Na y PSS afecta el suelo; el intermedio (24-39 m) tiene aguas dulces y salobres, sulfatadas sódicas y % Na, PSS y SP perjudicial. El acuífero superficial (17-21 m) contiene mayor salinidad (salobres), sódicas-cálcicas y se reparten en el límite entre sulfatada bicarbonatada o sulfatada clorurada, están bajo incumplimiento de normativas para cloruro, sulfato y nitrato. El aumento de iones disueltos en el acuífero superficial se atribuye a la disolución de yesíferas por aluvión en la zona, malas prácticas en procesos de riego-fertilización y la condición de aridez

Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway

Angiotensin-(1-9) is a peptide from the noncanonical renin-angiotensin system with anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. In the present study we aimed to elucidate it, basing us initially on previous work from our group and colleagues who proved a relationship between disturbances in mitochondrial morphology and calcium handling, associated with the setting of cardiac hypertrophy. Our first finding was that angiotensin-(1-9) can induce mitochondrial fusion through DRP1 phosphorylation. Secondly, angiotensin-(1-9) blocked mitochondrial fission and intracellular calcium dysregulation in a model of norepinephrine-induced cardiomyocyte hypertrophy, preventing the activation of the calcineurin/NFAT signaling pathway. To further investigate angiotensin-(1-9) anti-hypertrophic mechanism, we performed RNA-seq studies, identifying the upregulation of miR-129 under angiotensin-(1-9) treatment. miR-129 decreased the transcript levels of the protein kinase A inhibitor (PKIA), resulting in the activation of the protein kinase A (PKA) signaling pathway. Finally, we showed that PKA activity is necessary for the effects of angiotensin-(1-9) over mitochondrial dynamics, calcium handling and its anti-hypertrophic effects

La Constitución Política de los Estados Unidos Mexicanos 1917-2017 a 100 años

resultado de la primera revolución social del siglo XX fue la Constitución Política de los Estados Unidos Mexicanos, documento que plasmó las aspiraciones de toda una nación, marcando el rumbo de nuestro país hacia la democracia. Gracias a la Carta Magna hoy tenemos garantizados amplios derechos y podemos ejercer plenamente nuestras libertades. Celebro que la Universidad Autónoma del Estado de México conmemore los cien años de nuestra Constitución con la publicación de este libro, elaborado por un grupo multidisciplinario de investigadores, pertenecientes a diversas instituciones educativas del país, que analizan los diferentes artículos de la Constitución de 1917, desde los ámbitos histórico, filosófico, jurídico, educativo y social. Para el Gobierno del Estado de México, un libro conmemorativo de nuestra Carta Magna es invitación a reflexionar sobre las características de nuestras instituciones, así como la conveniencia de mantener o reformar sus artículos para continuar respondiendo a las necesidades de la ciudadanía. En cada propuesta de este libro, desde sus respectivos campos de estudio, los autores analizan los retos de la sociedad actual; además en su lectura e interpretación demuestran que los 136 artículos no son letra muerta, siguen vigentes