19,897 research outputs found
Rite to Death, Left to Life: Death Ritual as a Cross-Cultural Unit of Analysis
Death ritual is a nearly ubiquitous aspect of life within civilization, and serves the purpose of reconciling the logical positivist societal constructions that uphold social order with the fundamentally logic-breaking nature of death. This paper posits that death ritual serves as a strong cross-cultural unit of analysis as it provides insight into the defining socio-cultural traits and spiritual outlooks of different cultures. This unit of analysis is applied to Song-era Ch’an Buddhism, pre-colonial Hindu India, and Maori death ritual. For each of these examples, death rites are connected to aspects of art, culture, social organization, and spirituality or religion, and they are examined in relation to one another. The paper concludes with a further analysis of the consistent role death ritual plays in maintaining positivist social systems while being adapted to the disparate cultural needs of a given society
Promoting Social Emotional Engagement through a Universal Design for Learning
A positive, caring, and supportive school environment paired with high levels of student engagement and motivation for learning are key factors that significantly influence a student’s success in school and, as a result, for life beyond. With school districts tasked to educate a diverse student population with a range of abilities and learning styles, teachers are challenged to maintain high levels of motivation and engagement to facilitate learning within their individual classrooms.
An innovative program through the Marcus Autism Center specifically addresses these challenges within the context of the classroom through a Universal Design for Learning (UDL) framework relevant for all students in both the general education and special education settings. Based on the most current social neuroscience and on normative social emotional guidelines, the SEE-KS program facilitates teachers’ ability to meet the needs of all students through proactive planning that considers students’ developmental levels and learning styles.
By mentoring coaching teams at both the district and school levels, SEE-KS additionally places special emphasis on building on-site capacity of school districts through a financially sustainable staff development program. Videos and results of current collaborations between Marcus and several Georgia school districts will highlight SEE-KS’ potential to impact a range of students in Georgia’s schools.
Content use by parents: I will discuss a range of UDL supports that can be utilized by both school staff and families to promote social emotional engagement and learning for all students and why the specific supports are key at various developmental levels
Optical Identification of He White Dwarfs Orbiting Four Millisecond Pulsars in the Globular Cluster 47 Tucanae
We used ultra-deep UV observations obtained with the Hubble Space Telescope
to search for optical companions to binary millisecond pulsars (MSPs) in the
globular cluster 47 Tucanae. We identified four new counterparts (to MSPs
47TucQ, 47TucS, 47TucT and 47TucY) and confirmed those already known (to MSPs
47TucU and 47TucW). In the color magnitude diagram, the detected companions are
located in a region between the main sequence and the CO white dwarf cooling
sequences, consistent with the cooling tracks of He white dwarfs of mass
between 0.15 Msun and 0.20 Msun. For each identified companion, mass, cooling
age, temperature and pulsar mass (as a function of the inclination angle) have
been derived and discussed. For 47TucU we also found that the past accretion
history likely proceeded in a sub-Eddington rate. The companion to the redback
47TucW is confirmed to be a non degenerate star, with properties particularly
similar to those observed for black widow systems. Two stars have been
identified within the 2-sigma astrometric uncertainty from the radio positions
of 47TucH and 47TucI, but the available data prevent us from firmly assessing
whether they are the true companions of these two MSPs.Comment: 27 pages, 7 figures, Accepted for publication by Ap
The effect of functional roles on group efficiency
The usefulness of ‘roles’ as a pedagogical approach to support small group performance can be often read, however, their effect is rarely empirically assessed. Roles promote cohesion and responsibility and decrease so-called ‘process losses’ caused by coordination demands. In addition, roles can increase awareness of intra-group interaction. In this article, the effect of functional roles on group performance, efficiency and collaboration during computer-supported collaborative learning (CSCL) was investigated with questionnaires and quantitative content analysis of e-mail communication. A comparison of thirty-three questionnaire observations, distributed over ten groups in two research conditions: role (n = 5, N = 14) and non-role (n = 5, N = 19), revealed no main effect for performance (grade). A latent variable was interpreted as ‘perceived group efficiency’ (PGE). Multilevel modelling (MLM) yielded a positive marginal effect of PGE. Groups in the role condition appear to be more aware of their efficiency, compared to groups in the ‘non-role’ condition, regardless whether the group performs well or poor. Content analysis reveals that students in the role condition contribute more ‘task content’ focussed statements. This is, however, not as hypothesised due to the premise that roles decrease coordination and thus increase content focused statements; in fact, roles appear to stimulate coordination and simultaneously the amount of ‘task content’ focussed statements increases
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Rapid detection of Mycobacterium ulcerans with isothermal recombinase polymerase amplification assay.
Background
Access to an accurate diagnostic test for Buruli ulcer (BU) is a research priority according to the World Health Organization. Nucleic acid amplification of insertion sequence IS2404 by polymerase chain reaction (PCR) is the most sensitive and specific method to detect Mycobacterium ulcerans (M. ulcerans), the causative agent of BU. However, PCR is not always available in endemic communities in Africa due to its cost and technological sophistication. Isothermal DNA amplification systems such as the recombinase polymerase amplification (RPA) have emerged as a molecular diagnostic tool with similar accuracy to PCR but having the advantage of amplifying a template DNA at a constant lower temperature in a shorter time. The aim of this study was to develop RPA for the detection of M. ulcerans and evaluate its use in Buruli ulcer disease.
Methodology and principal findings
A specific fragment of IS2404 of M. ulcerans was amplified within 15 minutes at a constant 42°C using RPA method. The detection limit was 45 copies of IS2404 molecular DNA standard per reaction. The assay was highly specific as all 7 strains of M. ulcerans tested were detected, and no cross reactivity was observed to other mycobacteria or clinically relevant bacteria species. The clinical performance of the M. ulcerans (Mu-RPA) assay was evaluated using DNA extracted from fine needle aspirates or swabs taken from 67 patients in whom BU was suspected and 12 patients with clinically confirmed non-BU lesions. All results were compared to a highly sensitive real-time PCR. The clinical specificity of the Mu-RPA assay was 100% (95% CI, 84–100), whiles the sensitivity was 88% (95% CI, 77–95).
Conclusion
The Mu-RPA assay represents an alternative to PCR, especially in areas with limited infrastructure.
Author summary
Current diagnostic methods to detect M. ulcerans suffer from delayed time-to-results in most endemic countries by the prolonged period of time for the shipment and storage of samples to a distant, centralized laboratory. The M. ulcerans recombinase polymerase amplification assay (Mu-RPA) is a new, rapid diagnostic test developed for the detection of M. ulcerans infection, known commonly as Buruli ulcer, a chronic, debilitating, necrotizing disease of the skin and soft tissues. This assay is suitable for use on a portable detection device, with the potential to be used for quick diagnosis at the point of need, providing timely results to health workers at Buruli ulcer treatment clinics
Radio Timing and Optical Photometry of the Black Widow System PSR J1953+1846A in the Globular Cluster M71
We report on the determination of the astrometric, spin and orbital
parameters for PSR J1953+1846A, a "black widow" binary millisecond pulsar in
the globular cluster M71. By using the accurate position and orbital parameters
obtained from radio timing, we identified the optical companion in ACS/Hubble
Space Telescope images. It turns out to be a faint (m_F606W>=24, m_F814W>=23)
and variable star located at only ~0.06" from the pulsar timing position. The
light curve shows a maximum at the pulsar inferior conjunction and a minimum at
the pulsar superior conjunction, thus confirming the association with the
system. The shape of the optical modulation suggests that the companion star is
heated, likely by the pulsar wind. The comparison with the X-ray light curve
possibly suggests the presence of an intra-binary shock due to the interaction
between the pulsar wind and the material released by the companion. This is the
second identification (after COM-M5C) of an optical companion to a black widow
pulsar in a globular cluster. Interestingly, the two companions show a similar
light curve and share the same position in the color magnitude diagram.Comment: Accepted for publication by ApJ; 33 Pages, 10 Figures, 3 Table
Bayesian optimization of the PC algorithm for learning Gaussian Bayesian networks
The PC algorithm is a popular method for learning the structure of Gaussian
Bayesian networks. It carries out statistical tests to determine absent edges
in the network. It is hence governed by two parameters: (i) The type of test,
and (ii) its significance level. These parameters are usually set to values
recommended by an expert. Nevertheless, such an approach can suffer from human
bias, leading to suboptimal reconstruction results. In this paper we consider a
more principled approach for choosing these parameters in an automatic way. For
this we optimize a reconstruction score evaluated on a set of different
Gaussian Bayesian networks. This objective is expensive to evaluate and lacks a
closed-form expression, which means that Bayesian optimization (BO) is a
natural choice. BO methods use a model to guide the search and are hence able
to exploit smoothness properties of the objective surface. We show that the
parameters found by a BO method outperform those found by a random search
strategy and the expert recommendation. Importantly, we have found that an
often overlooked statistical test provides the best over-all reconstruction
results
Postdischarge assessment after a heart failure hospitalization: the next step forward.
Heart failure (HF) is the most frequent cause of hospitalization for patients >65 years of age. Mortality during the initial hospitalization ranges from 6% to 7% in Europe to 3% to 4% in the United States, depending on the length of hospital stay. Poor outcomes have universally been shown after discharge, with 60- to 90-day mortality rates of 5% to 15% and hospital readmission rates of 30%. Whereas the prognosis of patients with chronic HF has improved in recent years, there has been no change in the high risk of death or rehospitalization after an HF hospitalization. In addition to the lack of new therapies, incomplete relief from fluid overload, insufficient patient education, lack of implementation of evidence-based therapies, and poor postdischarge follow-up planning are among the main causes of these poor outcomes.
A better assessment of the patient at the time of discharge and in the following weeks seems therefore as mandatory. This article outlines the main components of such a program. These include the personnel who should be involved, i.e. HF specialists and cardiologists versus non-specialists, the variables which should be assessed, i.e. those related with congestion and fluid overload, the times when they should be assessed, as the phase at highest risk is immediately after discharge from hospital, and, finally, the aims of such programs. We retain that an improvement of post-discharge follow-up will be able to significantly improve patients’ outcomes with a rate of success comparable, if not greater, to that which can be achieved by new therapies
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