Analisis Pengendalian Persediaan Bahan Baku Rotan Pada Mebel Rotan Palunesia Collection Team Kota Palu

This research was conducted to; (1) Determine the optimal order quantity of raw rattan at Palunesia Collection Team Rattan Furniture 2014, (2) Knowing the amount of safety stock of raw rattan to be available at Palunesia Collection Team Rattan Furniture 2014, (3) Know the reorder point materials rattan conducted by Palunesia Collection Team Rattan Furniture 2014, (4) To Find out the total inventory cost of raw material should be issued by the rattan at Palunesia Collection Team Rattan Furniture 2014. Selection of a study conducted by purposive (deliberately) with the consideration that Rattan Furniture Palunesia Collection Team is one of the rattan furniture industry is still active to this day of 12 rattan furniture industry in Palu, on the other hand Palunesia Rattan Furniture Collection Team simply producing furniture as the main product. This study was conducted from April to May 2015. The data analysis that used in this research included Economiq Order Quantity (EOQ), Safety Stock, Reorder Point, and Total Inventory Cost. The results indicate that the optimal number of reservations of raw materials for fine rattan in 2014 for rattan poles Amounted to 105.61 kg, for Rattan pitrit optimal order quantity Amounted to 127.34 kg and rattan core optimal order quantity Amounted to 52.20 kg. Safety stock should always be available in 2014 for this type Amounted to 26.28 kg polished rattan, Rattan pitrit of 50.49 kg, and the types of rattan core of 12.37 kg. Reorder point to be done in 2014 for the types of rattan poles when the amount of raw materials Amounted to 30.54 kg, rattan pitrit at the time the raw material Amounted to 55.39 kg, and the types of rattan core when the amount of raw materials Amounted to 14, 32 kg. Total inventory costs incurred in 2014 for this kind of rattan poles Rp. 124,003.00, for a type of rattan pitrit Rp. 119,109.95 and for the types of rattan core Rp. 123,207.14

The Dynamic of Challenges of Managing Functional Civil Servant in Malang Regency Indonesia

: Simplifying the bureaucracy is a vocal policy priority initiated by President Joko Widodo. Basically, the simplification of the bureaucracy tries to rebuild the bureaucracy based on functions and expertise which ultimately results in better output and performance. So far, the consequence is the transfer of structural positions to functional positions. These changes also have an effect on changes in the management of the state civil apparatus (ASN). Even though the management of functional positions in regional government is still a formidable challenge. Therefore, this research aims to describe the various problems of managing functional positions in local government, which are increasingly complex with the presence of the obligation to simplify the bureaucracy. Researchers conducted interviews with multiple parties, both with managers of functional positions and with individuals who have functional positions in the Malang Regency Government. The results of this study show the dynamics of the problem from three aspects, namely, first from a comparative point of view in the era of bureaucratic simplification, which shows the lack of clarity in policies seen from policy clarity, policy direction, and policy effectiveness. The second point of view of the actor is that of a functional official who experiences various human resource management problems as a functional official. The third point of view is the management of functional positions that face cultural and structural challenges such as habits and human resources management at the local level

Profile Protein Autism Analysis Based Bioinformatics as Public Dissemination Materials in Malang About the Potensial Causes Autism

Kehidupan saat ini menawarkan berbagai kemudahan. Namun, seiring dengan hal tersebut ada banyak permasalahan yang memicu stress. Selain itu, terdapat banyak unsur kimia dan logam berat yang jika saling berinteraksi dapat menimbulkan berbagai macam penyakit mulai dari flu hingga kanker, termasuk autis. Penelitian ini bertujuan untuk menganalisis potensi profil protein dalam darah yang menyebabkan autis berdasarkan bioinformatik. Kemudian, disosialisasikan kepada masyarakat khususnya orang tua anak autis di Kota Malang sehingga dapat memberikan wawasan tentang autis. Penelitian ini juga dapat dikembangkan sebagai dasar penelitian laboratorium. Jenis penelitian ini adalah deskriptif kualitatif, menggunakan tiga database yaitu National Center for Biotechnology Information (NCBI), Uniprot, dan Protein Data Bank (PDB) serta menggunakan software Pymol. Hasil penelitian ini menunjukkan bahwa: 1) Protein dalam darah yang berpotensi menyebabkan autis berdasarkan artikel yaitu mTOR, Glutathione S Transferase P, Chemokine Monocyte Chemotactic Protein-1 (MCP-1), Interferon-∂-Inducible Protein-16 (IFI-16), dan serotonin; 2) Protein-protein tersebut setelah dianalisis dengan menggunakan tiga database (NCBI, Uniprot, dan PDB) menunjukkan bahwa protein Glutathione S Transferase P lebih berpotensi terhadap autis. Hal ini karena protein tersebut berfungsi untuk mencegah neurodegeneration; 3) Penelitian tentang penyebab autis sangat dibutuhkan oleh orang tua anak autis (masyarakat), sehingga dapat diminimalisir akses masuknya pemicu tersebut

Pengaruh Teknik Pencucian terhadap Hasil Pemeriksaan Cairan Mani dan Spermatozoa pada Kain Katun

Sexual offence is one of social problem that often happened in society. One of the best evidence used for investigation was semen and sperm found in a victim's dress. A dress usually made by cotton fabric. This research aimed to discover the influence of washing method to semen and sperm test result in a cotton fabric. This research planned as experimental research, used berberio test for semen and baechi test for sperm test. The result concluded that semen still visible up to 7 days, while the sperm only lasts 3 to 4 days. Conclusion there is no influence of washing found in semen test result while the washing method did influence the sperm test result in the cotton fabric

PENGEMBANGAN WISATA RELIGI MAKRABAH BUYUT NYAI MAS CARIK INDUNG WIWITAN SELENDANG BIRU KAMPUNG SUKABARES DESA BINANGUN KECAMATAN WARINGIN KURUNG KABUPATEN SERANG

Indonesia terkenal dengan banyaknya pahlawan daerah yang berhasil menumpas parapenjajah di bumi nusantara salahsatunya ada pahlawan cantik yang berasal dari Cirebon yakni bernama Nyai Mas Carik yang merupakan seorang putri cantik jelita dari Sultan Nuh di Kesultanan Pakungwati Cirebon. Pada awal abad 1490 Masehi, Nyai Mas Carik Pergi ke Kulon atau dalam bahasa Nasional pergi ke barat dengan upaya menyebarkan Agama Islam ke wilayah Banten dan Sekitarnya dimana masa itu Banten Sedang di kuasai oleh Kaisar Kubota yang berasal dari Jepang, dalam perjalanan Nyai Mas Carik Berangkat Menunggangi Ikan Talang, berbekal  Alquan dan Papan Nisan dengan didampingi Pengawalnya bernama Muhammad Idrus tujuan Nyai Mas Carik ke Daerah Kulon untuk menyebarkan agama islam, ilmu tauhid dan Syariah Islam. Mengusir Jepang dari Kulon. Nyai Mas Carik berhasil sampai ke daerah kulan Banten tepatnya di Karangantu, kedatangan Nyai Mas Carik tidak mendapatkan sambutan meriah saat itu di Kampung Kasubuhan sedang terjadi wabah penyakit barangsiapa yang meleawati dan menginjak ludah Nyai Mas Carik akan lumpuh dan konon katanya penyakit tersebut berasal dari Nyai Mas Carik sebagai seorang pendatang ternyata yang menyebarkan fitnah saat itu adalah para pribumi penghianat pribumi yag bekerja di bawah kepemimpinan Kaisar Kubota yang saat itu masih menguasai wilayah kulon

Cardiovascular Risk Profile in Health Cadres in Jatinangor, West Java

Background: Cardiovascular disease has very high morbidity and mortality, therefore, prevention of this disease becomes a national priority in the health programs. Health cadres, as an agent in community primary prevention, should have a good health condition. This study aimed to describe the cardiovascular risk profile in health cadresin Jatinangor, West Java.Methods: This was a cross-sectional study, conducted in Cilayung Village, Jatinangor, in September 2018. Consecutive sampling was performed on 20 health cadres aged 25 - 64 years old who did not have previous cardiovascular events such as coronary heart disease or stroke. Clinical data were collected consisting of blood pressure, body mass index (BMI), random blood glucose, history of diabetes mellitus, physical activity and active smoking habits. Cardiovascular risk was assessed using Jakarta cardiovascular scores and European Relative Risk Score.Results: Only 17 of 20 health cadres fulfilled the inclusion criteria with a systolic and diastolic blood pressure of 133.5±27.8 mmHg and 81.1±14.8 mmHg, respectively, and BMI of 27.4±5.3 kg/m2.The risk of cardiovascular disease in healthy cadres was at low (47.1%), moderate (41.2%) and high risk (11.7%). The average of the European Relative Risk score was 1.88±0.9. BMI >30 has a 40% high risk of cardiovascular disease.Conclusions: Most of the health cadres in Jatinangor, West Java have a low and moderate risk of cardiovascular disease, even though there is a small percentage that is at a high risk. The awareness for prevention and management programs for risk factors needs to be raised among health cadres. .

Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and molecular dynamics simulation

A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed, subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass analytical techniques and evaluated as acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer's disease (AD). The results of predicted ADMET study demonstrated the drug-likeness properties of the titled compounds with developmental challenges in lipophilicity and solubility parameters. The in vitro assessment of the synthesized compounds revealed that all of them showed significant activity (IC50 ranging from 0.42 to 1.296 µM) towards AChE compared to the standard drug, galantamine (IC50 = 1.142 ± 0.027 µM). Among these, compound 23e displayed the most potent inhibitory activity with IC50 value of 0.42 ± 0.019 µM. Cytotoxicity of all compounds was tested on normal human hepatic (THLE-2) cell lines at three different concentrations using the MTT assay, in which none of the compound showed significant toxicity at the highest concentration of 1000 µg/ml compared to the control group. Based on the docking study against AChE, the most active derivative 23e was orientated towards the active site and occupied both catalytic anionic site (CAS) and peripheral anionic site (PAS) of the target enzyme. In-silico studies revealed tested showed better inhibition activity of AChE compared to Butyrylcholinesterase (BuChE). Molecular dynamics simulation explored the stability and dynamic behavior of 23e- AChE complex

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored. Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays. Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements

This paper presents new sets of parameters (“tunes”) for the underlying-event model of the HERWIG7 event generator. These parameters control the description of multiple-parton interactions (MPI) and colour reconnection in HERWIG7, and are obtained from a fit to minimum-bias data collected by the CMS experiment at s=0.9, 7, and 13Te. The tunes are based on the NNPDF 3.1 next-to-next-to-leading-order parton distribution function (PDF) set for the parton shower, and either a leading-order or next-to-next-to-leading-order PDF set for the simulation of MPI and the beam remnants. Predictions utilizing the tunes are produced for event shape observables in electron-positron collisions, and for minimum-bias, inclusive jet, top quark pair, and Z and W boson events in proton-proton collisions, and are compared with data. Each of the new tunes describes the data at a reasonable level, and the tunes using a leading-order PDF for the simulation of MPI provide the best description of the dat