Understanding the mechanism of cardiac gene remodelling via PPAR-α signalling in cardiac hypertrophy

identified and unveiled the functional relevance of differentially expressed miRNAs in ISO-treated PPAR α-/- mice. As of now, limited literature was available about miRNA abundance and their altered expression in cardiac hypertrophy models in the absence of PPAR α protein. So for the very first time, using PPAR α-/- mice, we showed that several miRNAs are differentially expressed that have never been reported in context to cardiac hypertrophy. Additionally, pathway analysis, indicated that the dysregulated miRNAs target genes were enriched mostly in signal transduction pathways. Overall, our findings suggest the miRNAs expression profile of miRNAs like mmu-miR3102-5p; mmu-miR-30a-5p; mmu-miR-30c-5p; mmu-miR-466i-5p is significantly altered in response to cardiac hypertrophy in PPAR-/- mice that eventually impacts the apoptotic pathway in a negative manner

Reflection of culture and Tradition in Manju Kapur’s Home

Manju Kapur is a versatile author, and all of her novels portray the true and authentic picture of human life under various circumstances. The novels of Manju Kapur invite our serious attention, and the quality that we find in her books is of rare merit and distinction. Home, one of her most successful delineations from the perspective of the social and cultural milieu, forces the readers to think deeply on a lot of issues of family life. Nisha, the protagonist has to suffer a lot just because the members of her family do not try for equality and justice. The present paper tries to present such more delineation. It reflects the cultural and traditional aspects also

George Orwell’s Nineteen Eighty Four: A Dystopian Novel

The famous British author George Orwell, pen name of Eric Arthur Blair, was born in motihari (East Champaran, Bihar), then under Bengal Presidency in British India on June 25, 1903. However, he left Motihari when he was only one year old, went with his mother to England for his schooling and for higher studies, wrote many novels, but became famous for the two, Animal Farm, a modern beast fable attacking Russian revolution and Stalinism, and 1984, a dystopian novel setting forth his fear of totalitarian government and Increasingly bureaucratic state of the future, Nineteen Eighty four often published as 1984, is a dystopian novel published in 1949. Set in Oceania, one of the three Intercontinental super states that divided the world among themselves after a global atomic war, the story unfolds in London, the chief city of Airstrip one, governed by the Party, dictated by political system euphemistically named Engsocialism or Ingsoc in the government Invented language called newspeak, under the privileged elite of the Inner Party, that persecutes individualism and independent thinking headed by the big brother which is a tyrannical figure “Posters screaming” BROTHER IS WATCHING YOU. Big brother, is just the name, someone who is unseen and all the people are scared of Big brother. He keeps an eye on everything. He has CCTV, telescreens to control the society. Every street corner, every lamp post, and every wall has life- size picture of Big Brother's face, his eyes following wary citizens as they walk, cast it.

Comparative Evaluation of Oral Aprepitant vs. Injection Palonosetron for Preventing Post-operative Nausea and Vomiting in Laparoscopic Cholecystectomy Patients under General Anaesthesia: A Randomized Trial

Background: Post-operative nausea and vomiting (PONV) are common and distressing complications in individuals undergoing surgical procedures, particularly laparoscopic cholecystectomy. Effective management of PONV is crucial for patient comfort, quicker recovery, and reduced healthcare costs. This study focused to compare the efficacy of oral aprepitant and injection palonosetron in preventing PONV in such surgical settings. Methods: A randomized controlled trial was conducted, involving 120 participants undergoing laparoscopic cholecystectomy. Individuals were divided into three groups: Group A (oral aprepitant), Group P (injection palonosetron), and Group C (placebo). The occurrence of nausea and vomiting was monitored at various intervals post-surgery, and statistical analysis was performed to estimate the efficacy of the treatments. Results: While all groups demonstrated some effectiveness in preventing nausea, with no significant statistical differences, Group A (Aprepitant) showed a significantly higher efficacy in preventing vomiting compared to Groups P and C. Aprepitant was notably more effective, suggesting its superiority as an antiemetic in this surgical context. Conclusion: Aprepitant emerges as a potentially more effective antiemetic agent for preventing vomiting in patients undergoing laparoscopic cholecystectomy, compared to palonosetron and placebo. Recommendations: Future research should focus on optimizing antiemetic regimens tailored to individual patient needs and specific surgical procedures. Further studies are also recommended to explore the long-term effects and cost-effectiveness of using aprepitant in perioperative care

ASSESSING THE EFFECT OF DEXMEDETOMIDINE DOSAGES ON SHORT-TERM COGNITIVE FUNCTION IN GERIATRIC PATIENTS UNDERGOING HEAD AND NECK CANCER SURGERY: A CROSS-SECTIONAL STUDY.

Background. Geriatric patients undergoing head and neck cancer surgery often face cognitive challenges postoperatively. The study aims to evaluate the impact of varying dosages of Dexmedetomidine (DEX) on short-term cognitive function in this vulnerable population. Methods. A prospective study was carried out, and patients were divided into two groups based on DEX infusion rates. Inclusion criteria encompassed specified surgical regions, while exclusion criteria ensured study population homogeneity. Data on demographics, medical history, surgical details, and DEX infusion were collected. Short-term cognitive function was assessed using the Mini-Mental State Examination (MMSE) on postoperative Day 2.  Results. Ninety participants were enrolled, with Group A (lower DEX rates, n=40) and Group B (higher DEX rates, n=50). Baseline characteristics were similar between groups. Mean MMSE scores were considerably higher in Group A (27.5, 95% CI: 26.8-28.2) compared to Group B (26.0, 95% CI: 25.3-26.7) (p < 0.05). The incidence of postoperative delirium was lower in Group A (10%) than in Group B (20%) (p = 0.12). Hemodynamic stability and pain scores were similar between groups.  Conclusion. Lower DEX infusion rates were associated with better short-term cognitive function in geriatric patients undertaking head and neck cancer surgery. However, further research is needed to validate these findings and explore potential mechanisms underlying cognitive effects.  Recommendations. Based on these findings, clinicians may consider adjusting DEX infusion rates to optimize cognitive outcomes in geriatric patients undergoing similar surgical procedures

Assessing the effect of Dexmedetomidine Dosages on Short-Term Cognitive Function in Geriatric Patients undergoing Head and Neck Cancer Surgery

Background: Geriatric patients undergoing head and neck cancer surgery often face cognitive challenges postoperatively. The study aims to assess the impact of varying dosages of Dexmedetomidine (DEX) on short-term cognitive function in this vulnerable population. Methods: A prospective study was conducted, and patients were divided into two groups based on DEX infusion rates. Inclusion criteria encompassed specified surgical regions, while exclusion criteria ensured study population homogeneity. Data on demographics, medical history, surgical details, and DEX infusion were collected. Short-term cognitive function was assessed using the Mini-Mental State Examination (MMSE) on postoperative Day 2. Results: Ninety participants were enrolled, with Group A (lower DEX rates, n=40) and Group B (higher DEX rates, n=50). Baseline characteristics were similar between groups. Mean MMSE scores were significantly higher in Group A (27.5, 95% CI: 26.8-28.2) compared to Group B (26.0, 95% CI: 25.3-26.7) (p < 0.05). Incidence of postoperative delirium was lower in Group A (10%) than Group B (20%) (p = 0.12). Hemodynamic stability and pain scores were similar between groups. Conclusion: Lower DEX infusion rates were associated with better short-term cognitive function in geriatric patients undergoing head and neck cancer surgery. However, further research is needed to validate these findings and explore potential mechanisms underlying cognitive effects. Recommendations: Based on these findings, clinicians may consider adjusting DEX infusion rates to optimize cognitive outcomes in geriatric patients undergoing similar surgical procedures

DC Motor Dual Close-Loop PID Speed-Tuning System on The Basis of ABC Algorithm

The DC Servo Motors has top position in various servo motor mechanisms. It is important to study DC Servo motor stability for position control study. Generally transient responses of DC Servo Motor are improved by using PID controller. Currently, to provide workable initial value most tuning methods have been designed. DC servo motor stability for the speed get unstable without any controller . The stability of the system get unstable after 2 second . When the design system will work without PID controller then the stability of the current and speed of the motor is not stable . it is verifying in the form of sinusoidal waveform . For any good design system , system will work in a stable form for current and speed graph . As the graph is showing that the graphs of the DC servo motor is stable up to 2 sec. But the after 2 second the graphs will get unstable . This type of problem can damage the complete model where this type of motor will be used . In this paper we are improving the stability of the current and speed for the DC motor by apply PID controller

Comparative Analysis of MANET Reactive Protocols

an Ad - hoc network is a group of mobile nodes. In an ad - hoc network a mobile node can directly communicate with the other node that lies in its transmission range or it can forward its information to the other node that will act as an intermediate node and forwards the information to the desired node using multi - hop links. In such a network there is no need of any infrastructure. Ad - hoc networks routing protocols are classified into two categories: Proactive/table - driven and reactive/on - demand. Reactive rou ting protocol is used whenever a communication is requested. There are two types of reactive protocols: AODV (Ad hoc on - demand distance vector protocol) and DSR (Dynamic source routing protocol). In one type of scenario one protocol may perform best while another may perform worst, so there is a need to determine an optimal one out of these in a more dynamic environment. The differences in the working of these protocols lead to significant performance differentials for both of these protocol

Review Paper Based On the Relation between the Strength of Concrete Cubes and Cylinders

ABSTRACT This paper reports the review about comparison of the compressive strength of cubes and cylinders of different grades of concrete. The cubes of standard size of 150x150x150 mm were cured and tested after 7 and 28 days each. The cylinders of standard size 150mm dia. and 300mm height are cured and tested after 7 and 28 days each

MANAGEMENT OF DIABETES WITH COVID-19: A REVIEW

Objective: As of now, the world is struggling with a serious pandemic of disease 2019 Coronavirus (COVID-19), which was emerged from Wuhan in China, originated by the novel coronavirus 2019 (SARS-CoV-2). COVID-19 is a viral illness, which is occurring on a large scale in every nation of the globe. Symptoms of coronavirus mainly include fever, fatigue, cough, headache, pneumonia and in severe condition, there is respiratory distress. The deadly virus alarmed the world to be on high alert as the number of rising cases and the death toll rising as the day passes. Methods: We have searched for articles of preference and interest systematically in sources like Google Scholar, PubMed, and other outlets. Results: Management in the case of diabetes is really necessary to decrease their mortality. Certain management parameters need to be followed to take care of patients suffering from both diseases. Conclusion: In this review, we highlighted the role of different medicines like chloroquine, lopinavir, and hydroxychloroquine for the remedy of this pandemic. We also discussed the chest Computed tomography functions and Real-time polymerase chain reaction for the screening of the outbreak. The center of attention of this review majorly on the care of diabetes throughout the time of the COVID-19 epidemic