Centro cívico de Dunstable Inglaterra

This civic centre has two storeys: — The ground floor provides room for a vestibule, cloakroom, the management office, washroom for the public, the large elliptic hall and access to the stalls, dressing room for the actors, and a kitchen in communication with the restaurant situated on the higher level; — The second storey comprises a hall and bar, council room, restaurant, additional dressing rooms for actors, storage room for dresses and other performance paraphernalia, and the room for the cinematographic projectors. This civic centre has many useful functions, such as exhibitions, banquets, dress balls, theatrical performances, etc. The elliptical hall accommodates 750 seated spectators.El edificio tiene dos plantas de altura: La planta baja aloja: el vestíbulo, el guardarropas, las oficinas administrativas, los aseos para el público, el patio de butacas de la gran sala elíptica, camerinos para los artistas, una cocina en comunicación con el restaurante situado en el nivel superior, etc. La primera planta comprende: el vestíbulo con su ambigú, la sala de juntas, un restaurante, los camerinos, el almacén para attrezzo, la cabina de proyección, etc. El «Centro» se destina a usos múltiples: exposiciones, banquetes, bailes de gala, representaciones teatrales, etc. La sala elíptica tiene capacidad para 750 personas sentadas

Overview of the In-Space Manufacturing Technology Portfolio

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Stat3 Controls Tubulointerstitial Communication during CKD

In CKD, tubular cells may be involved in the induction of interstitial fibrosis, which in turn, leads to loss of renal function. However, the molecular mechanisms that link tubular cells to the interstitial compartment are not clear. Activation of the Stat3 transcription factor has been reported in tubular cells after renal damage, and Stat3 has been implicated in CKD progression. Here, we combined an experimental model of nephron reduction in mice from different genetic backgrounds and genetically modified animals with in silico and in vitro experiments to determine whether the selective activation of Stat3 in tubular cells is involved in the development of interstitial fibrosis. Nephron reduction caused Stat3 phosphorylation in tubular cells of lesion-prone mice but not in resistant mice. Furthermore, specific deletion of Stat3 in tubular cells significantly reduced the extent of interstitial fibrosis, which correlated with reduced fibroblast proliferation and matrix synthesis, after nephron reduction. Mechanistically, in vitro tubular Stat3 activation triggered the expression of a specific subset of paracrine profibrotic factors, including Lcn2, Pdgfb, and Timp1. Together, our results provide a molecular link between tubular and interstitial cells during CKD progression and identify Stat3 as a central regulator of this link and a promising therapeutic target

Patients referred to a pain management clinic: beliefs, expectations and priorities

Aim. This paper is a report of a study to explore patients' pain-beliefs and emotions at the point of referral to a pain clinic, their expectations of the clinic and their priorities for improvement in aspects of their lives affected by pain. Background. Chronic pain is a common experience and, although the percentage of people with pain referred to pain clinics is increasing, they often experience complex journeys through the healthcare system. Patients' beliefs about pain have been shown to influence their experience of pain and treatment outcomes, with a focus on the organic cause of pain reported. Methods. Three focus groups were convened with 18 participants. Ten statements about pain were distributed to each participant and ranked according to their priorities. The data were collected in 2002-2003. Findings. The participants' beliefs were dominated by the search for a firm diagnosis and cure. Participants held three main beliefs; that the cause of the pain must be established; that other people do not believe in the pain of a person without a firm diagnosis; and that painkillers are a way of 'fobbing you off'. Participants had little knowledge and few concrete expectations of the pain clinic. Their main priorities for improvement were 'less pain', 'some pain free times', and being able to do more 'everyday things'. Conclusins. Staff delivering pain management services must understand patients' beliefs and expectations and explain their own perspectives in order to provide a sound basis for working together