16 research outputs found
Oligosaccharide recognition and binding to the carbohydrate binding module of AMP-activated protein kinase
- Publication venue
- Federation of European Biochemical Societies. Published by Elsevier B.V.
- Publication date
- 30/10/2007
- Field of study
AbstractThe AMP-activated protein kinase (AMPK) contains a carbohydrate-binding module (β1-CBM) that is conserved from yeast to mammals. β1-CBM has been shown to localize AMPK to glycogen in intact cells and in vitro. Here we use Nuclear Magnetic Resonance spectroscopy to investigate oligosaccharide binding to 15N labelled β1-CBM. We find that β1-CBM shows greatest affinity to carbohydrates of greater than five glucose units joined via α,1→4 glycosidic linkages with a single, but not multiple, glucose units in an α,1→6 branch. The near identical chemical shift profile for all oligosaccharides whether cyclic or linear suggest a similar binding conformation and confirms the presence of a single carbohydrate-binding site
The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production
- Author
- Abramoff
- Afonine
- Altschul
- Aslund
- Bader
- Bader
- Bader
- Baker
- Bardwell
- Bardwell
- Begoña Heras
- Blommel
- Burmeister
- Chakraborty
- Chen
- Chung
- Crow
- Dailey
- Derewenda
- Dolinsky
- Dolinsky
- Dutton
- Emsley
- Evans
- Früh
- Gasteiger
- Gilbert
- Guddat
- Heras
- Holmgren
- Horne
- Hu
- Huber-Wunderlich
- Inaba
- Inaba
- Jennifer L. Martin
- Joosten
- Kabsch
- Kai-En Chen
- Kieran Rimmer
- Kurz
- Liang
- Macnab
- Maria A. Halili
- Martin
- Martin
- Martin J. Scanlon
- McCarthy
- McCoy
- McPhillips
- Nelson
- Pace
- Patricia M. Walden
- Paxman
- Peek
- Peterson
- Pooja Sharma
- Roberts
- Rozhkova
- Shevchik
- Shimizu
- Shouldice
- Studier
- Thompson
- Vivian
- Winn
- Wunderlich
- Publication venue
- 'International Union of Crystallography (IUCr)'
- Publication date
- 01/10/2012
- Field of study
The enzyme TcpG is a periplasmic protein produced by the Gram-negative pathogen Vibrio cholerae. TcpG is essential for the production of ToxR-regulated proteins, including virulence-factor pilus proteins and cholera toxin, and is therefore a target for the development of a new class of anti-virulence drugs. Here, the 1.2 Å resolution crystal structure of TcpG is reported using a cryocooled crystal. This structure is compared with a previous crystal structure determined at 2.1 Å resolution from data measured at room temperature. The new crystal structure is the first DsbA crystal structure to be solved at a sufficiently high resolution to allow the inclusion of refined H atoms in the model. The redox properties of TcpG are also reported, allowing comparison of its oxidoreductase activity with those of other DSB proteins. One of the defining features of the Escherichia coli DsbA enzyme is its destabilizing disulfide, and this is also present in TcpG. The data presented here provide new insights into the structure and redox properties of this enzyme, showing that the binding mode identified between E. coli DsbB and DsbA is likely to be conserved in TcpG and that the [beta]5-[alpha]7 loop near the proposed DsbB binding site is flexible, and suggesting that the tense oxidized conformation of TcpG may be the consequence of a short contact at the active site that is induced by disulfide formation and is relieved by reduction
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo Musicò
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- Annaïg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila Oláh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- Aurélie Ledreux
- Avital A Rodal
- Ayesha Saleem
- Ákos M Lőrincz
- Áurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E Benediktsdóttir
- Bernadett R Bodnár
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
- Beth Holder
- Bianca C Pachane
- Biao Lu
- Bingdong Sui
- Birke J Benedikter
- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
- Bong Hwan Sung
- Bonita H Powell
- Brachyahu M Kestecher
- Bradley Whitehead
- Brian Dobosh
- Bridges Esther M.
- Brucale Marco
- Bruce A Stanton
- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
- Camille V Trinidad
- Cansu Gorgun
- Carla Mazzeo
- Carlos Salomon
- Carmen Campos-Silva
- Carmen Carceller
- Carmen Fernandez-Becerra
- Carmen Jerónimo
- Carney Randy P.
- Carolina Balbi
- Carolina Soekmadji
- Caroline Gilbert
- Caroline J Reddel
- Catherine A Sánchez
- Catherine Martel
- Cecilia Bucci
- Cecilia Lässer
- Celine Elie-Caille
- Cécile E Malnou
- Changhai Tian
- Changjin Lee
- Chantal M Boulanger
- Charisse N Winston
- Charles J Blijdorp
- Charles P Lai
- Charlotte Lawson
- Chaya Brodie
- Chelsea N Davis
- Cherie Blenkiron
- Chiew Yong Ng
- Chihchen Chen
- Chitranshi Nitin
- Christian Neri
- Christian P Pallasch
- Christian Preußer
- Christina Nedeva
- Christopher Fernandez-Prada
- Chungmin Han
- Claudia M Radu
- Cláudio Pinheiro
- Clémence Belleannée
- Clotilde Billottet
- Clotilde Théry
- Cocucci Emanuele
- Colin L Hisey
- Cora L Alvarez
- Coralie L Guerin
- Crescitelli Rossella
- Crislyn D'Souza-Schorey
- Cristina Fornaguera
- Cristina Pr Xavier
- Cristóbal Cerda-Troncoso
- D Craig Hooper
- D Michiel Pegtel
- Daan Paget
- Dakota Gustafson
- Dalila Iannotta
- Daniel Bachurski
- Daniel H Kim
- Daniel J MacPhee
- Daniel S Lark
- Daniel W Hagey
- Daniela Boselli
- Daniela Freitas
- Daniela L Papademetrio
- Daniele D'Arrigo
- Daniele Noël
- Danielle J Beetler
- Danilo Mladenović
- David A Armstrong
- David A Routenberg
- David C Lyden
- David D Roberts
- David J Lundy
- David Juncker
- David Laurin
- David Otaegui
- David P Al-Adra
- David R Brigstock
- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
- Delaram Khamari
- Denis Corbeil
- Dennis K Jeppesen
- Di Vizio Dolores
- Diego Kyburz
- Dilara C Ozkocak
- Dimitri Aubert
- Dina Ak Ahmed
- Dinesh Upadhya
- Dionysios C Watson
- Dirk P Dittmer
- Dirk Strunk
- Dmitry Ter-Ovanesyan
- Dolores Di Vizio
- Dominic Guanzon
- Donald G Phinney
- Dong Jun Park
- Dong-Gyu Jo
- Dong-Sup Lee
- Dongin Kim
- Dorian Forte
- Dorival M Rodrigues-Junior
- Doste R Mamand
- Driedonks Tom A. P.
- Dylan Burger
- Edina Gyukity-Sebestyén
- Edison Salas-Huenuleo
- Edit I Buzas
- Eduardo Marbán
- Eduardo Martínez-Martínez
- Eduardo Reategui
- Edveena Hanser
- Edwin van der Pol
- Efrat Levy
- Eisuke Dohi
- Elena Aikawa
- Elena Izquierdo
- Elena Khomyakova
- Elena S Martens-Uzunova
- Elena Vacchi
- Elham Hosseini-Beheshti
- Elias Sulaiman
- Elisa Lázaro-Ibáñez
- Elisa Tonoli
- Elise Madec
- Elizabeth R Dellar
- Elke Pogge von Strandmann
- Ellis K Fok
- Elżbieta Karnas
- Emanuele Cocucci
- Emilia Scharrig
- Emilio Di Ianni
- Emma Kc Symonds
- Enis Kostallari
- Eqbal Mohamadi
- Erdbrügger Uta
- Erez Eitan
- Eric Boilard
- Erica Bazzan
- Ernesto Gargiulo
- Esmahan Durmaz
- Estefanía Lozano-Andrés
- Esther M Bridges
- Esther Nm Nolte-'t Hoen
- Eszter Á Tóth
- Etienne Doré
- Etienne Moussay
- Eva Rohde
- Eva-Maria Krämer-Albers
- Evan A Gizzie
- Ewa K Zuba-Surma
- Ewa Ł Stępień
- Émilie Velot
- Fabian Braun
- Fabiana Geraci
- Fabienne Archer
- Fabrice Lucien
- Faezeh Shekari
- Faisal J Alibhai
- Falcon‐Perez Juan M.
- Farah Fatima
- Farrukh Aqil
- Fatah Kashanchi
- Fatemeh Momen-Heravi
- Fausto Almeida
- Federica Collino
- Federico Cocozza
- Federico Colombo
- Ferdinando Pucci
- Fernanda Jadue
- Fernando Souza-Fonseca-Guimaraes
- Flora Guerra
- Florian Puhm
- Fons Aj van de Loo
- Francesc E Borràs
- Francesca Perut
- Francesco Valle
- Francois Mullier
- Frank Rm Stassen
- Franz L Ricklefs
- Fred H Hochberg
- Frederic St-Denis-Bissonnette
- Frederik J Verweij
- Fu Qing‐Ling
- Fumihiko Urabe
- Gabrielis Kundrotas
- Gabriella Dobra
- Gabriella Pocsfalvi
- Gagan Deep
- Ganesh V Shelke
- Ganesha Poojary
- Ganna Stepanova
- Geneviève Bart
- Georges E Grau
- Georgia K Atkin-Smith
- Georgios Giamas
- Géraldine C Genard
- Ghasem Hosseini Salekdeh
- Gi-Hoon Nam
- Giorgia Melli
- Giovanni Camussi
- Giuseppina Poppa
- Gloria Alvarez-Llamas
- Goberdhan Deborah C. I.
- Gorjana Rackov
- Graca Raposo
- Gregory E Rice
- Gregory Lavieu
- Guanshu Liu
- Guido Jenster
- Guillaume van Niel
- Guoku Hu
- Guoping Li
- Hadi Valadi
- Hafiza Padinharayil
- Hakho Lee
- Han Sang Kim
- Hang Yin
- Hannah K Jackson
- Hanser Edveena
- Hao Chen
- Hao Zhang
- Hargita Hegyesi
- Harmeet Malhi
- Harris Adrian L.
- Harry Holthofer
- Harry Vm Spiers
- Haseeb Zubair
- Haughey Norman J.
- Heather H Pua
- Hendrix An
- Henrique Girão
- Heon-Jin Lee
- Hernando A Del Portillo
- Hernán González-King Garibotti
- Héctor Peinado
- Hidetoshi Tahara
- Hilal A Rather
- Hill Andrew F.
- Hiroaki Komuro
- Honami Naora
- Hongkuan Fan
- Houjian Cai
- Huaqi Su
- Hugo R Caires
- Hyo Jung An
- Hyungsoon Im
- Igea D'Agnano
- Igor V Kurochkin
- Ilaria Giusti
- Ilaria Prada
- Iliya Lefterov
- Imola Cs Szigyártó
- In-San Kim
- Indira Prasadam
- Inge Nelissen
- Ioannis Azoidis
- Irene Bertolini
- Irina Nazarenko
- Irma Schabussova
- Isabel Barranco
- Ivan J Vechetti
- Ivan Kh Poon
- Ivanov Alexander R.
- Ivica Marić
- J Brian Byrd
- Jacky G Goetz
- Jacob A Cleary
- Jamal Ghanam
- Jameel M Inal
- James G Patton
- Jan Lötvall
- Jan Van Deun
- Jana Zarubova
- Jane Howard
- Janine Stam
- Janis A Müller
- Janne Leivo
- Janos Zempleni
- Janusz Rak
- Jascinta P Santavanond
- Jason P Webber
- Javier Ramirez-Ricardo
- Javier Sotillo
- Jean-Marie Bach
- Jeff Bouffard
- Jeff Wm Bulte
- Jeffrey L Franklin
- Jeffrey S Schorey
- Jen Alexander-Brett
- Jenifer Pendiuk Goncalves
- Jennifer C Jones
- Jens C Luoto
- Jens Gruber
- Jerome Paggetti
- Jessica Gobbo
- Jessica Schiavi-Tritz
- Jessie Santoro
- Jiao Jiao Li
- Jing Jin
- Jiri Hrdy
- Jisook Moon
- Joanne Lannigan
- Joao N Ferreira
- Joaquin Seras-Franzoso
- Joel Ej Beaumont
- Johan Skog
- Johann M Gudbergsson
- Johanna Mm Puutio
- Johannes Oesterreicher
- John J Bissler
- John J Miklavcic
- John J Tomes
- John P Nolan
- Johnathon D Anderson
- Jonathan Degosserie
- Jonathan Leor
- Joost Pg Sluijter
- Jordi Roca
- Joseph Whitley
- Joshua A Welsh
- Joshua D Spitzberg
- Jovanovic‐Talisman Tijana
- Joy Wolfram
- Juan M Falcon-Perez
- Juan P Tosar
- Juhee Park
- Julia C Gross
- Julia Kuligowski
- Julia V Burnier
- Julian Swatler
- Julie A Saugstad
- Julie Constanzo
- Julien Saint-Pol
- Juntaro Matsuzaki
- Justus C Ndukaife
- Júlia Costa
- Kaiping Burrows
- Kaloyan Takov
- Kanchana K Ayyar
- Karen Forbes
- Karin Ekström
- Karolina Soroczyńska
- Kasper M Rouschop
- Kasra Khalaj
- Katelyn A Bruno
- Katherine E White
- Kathleen M Lennon
- Kathrin Gärtner
- Kathryn L Howe
- Katrin S Reiners
- Kazunari Akiyoshi
- Kelly Coutant
- Kelly Cs Roballo
- Kendall R Van Keuren-Jensen
- Kenneth W Witwer
- Kenny Man
- Kentaro Jingushi
- Kerstin Menck
- Kevin Leandro
- Khairul I Ansari
- Kieran Brennan
- Kimberley L Alexander
- Kirsi Rilla
- Kirsty M Danielson
- Kiyotaka Shiba
- Koen Breyne
- Koji Ueda
- Konxhe Kulaj
- Krishna P Maremanda
- Krishnan Anand
- Kristyna Turkova
- Krisztina Buzas
- Krisztina Németh
- Krisztina Pálóczi
- Krisztina V Vukman
- Kruh‐Garcia Nicole A.
- Ku'ulei‐Lyn Faustino Vroniqa
- Kyburz Diego
- Kyle I Mentkowski
- Kyle P Bramich
- Kyungmoo Yea
- Laura Bongiovanni
- Laura Grech
- Laura J Vella
- Laura Yedigaryan
- Lauren A Newman
- Lausonia Ramaswamy
- Lawrence W Chamley
- Lässer Cecilia
- Leandra K Figueroa-Hall
- Lei Zheng
- Lenassi Metka
- Lennon Kathleen M.
- Leon G Coleman Jr
- Leonardo Nimrichter
- Leonid Margolis
- Leonidas A Phylactou
- Leonora Balaj
- Lesley Cheng
- Liang Dong
- Liang Wu
- Lien Lippens
- Lifang Yang
- Lila Drittanti
- Liliia Paniushkina
- Lim Sai Kiang
- Ling-Qing Yuan
- Linglei Jiang
- Lissette Retana Moreira
- Loes Teeuwen
- Loïc Steiner
- Lorena Martin-Jaular
- Lorena Urbanelli
- Lorraine O'Driscoll
- Lothar C Dieterich
- Louise C Laurent
- Lötvall Jan
- Luca Musante
- Lucas Walther
- Lucia Paolini
- Lucia R Languino
- Lucienne Tritten
- Lucio Barile
- Ludovic Vinay
- Ludwig Ermann Lundberg
- Luis A Ortiz
- Luis Arteaga-Blanco
- Luis Mariñas-Pardo
- Luis Pereira de Almeida
- Luisa Weiss
- Luke C McIlvenna
- Luke van der Koog
- Lynn Pulliam
- M Helena Vasconcelos
- M Madhy Garcia Garcia
- M. AlbaneseMembro del Collaboration Group
- Maarten P Bebelman
- Maddox Adam L.
- Magdalena E Wysmołek
- Magdalena J Lorenowicz
- Mahlegha Ghavami
- Mahoney Mỹ G.
- Maiken Mellergaard
- Maimonah E Al-Masawa
- Maja Kosanović
- Makon-Sébastien Njock
- Malene Møller Jørgensen
- Malgorzata Czystowska-Kuzmicz
- Mangesh D Hade
- Manuel Gomez-Florit
- Manuel Varas-Godoy
- Manuela Basso
- Marc-André Langlois
- Marca Hm Wauben
- Marcel I Ramirez
- Marcela A Cucher
- Marcelo A Mori
- Marcin Jurga
- Marcio L Rodrigues
- Marco Brucale
- Marco Falasca
- Margaret M Mc Gee
- Margarida Viola
- Maria D Mayan
- Maria Eldh
- Maria Elena Cicardi
- Maria Harmati
- Maria I Guillén
- Maria Kaparakis-Liaskos
- Maria Noé Garcia
- Mariama Mbengue
- Marianne S Joerger-Messerli
- Marieke T Roefs
- Marija Holcar
- Marije E Kuipers
- Marina Cretich
- Mario Gimona
- Mariola J Ferraro
- Marit Inngjerdingen
- María Fernández-Rhodes
- María José Alcaraz
- María Yáñez-Mó
- Mark C Allenby
- Mark D Hulett
- Mark J McCann
- Mark J McVey
- Mark L Weiss
- Mark Samuels
- Mark Santos
- Marni D Boppart
- Marta Garcia-Contreras
- Marta Monguió-Tortajada
- Martens‐Uzunova Elena S.
- Martijn Jc van Herwijnen
- Martin E van Royen
- Martin Olivier
- Martin Wolf
- Martina Gabrielli
- Marvin Droste
- Mary Bebawy
- Maryam Azlan
- Marzena Kurzawa-Akanbi
- Masaharu Somiya
- Masahiko Kuroda
- Masahiro Morimoto
- Masako Harada
- Masamitsu Kanada
- Masood Kamali-Moghaddam
- Massimo Bottini
- Massimo Dominici
- Mateja E Kreft
- Mathilde Bergamelli
- Mathilde Mosser
- Matias Ostrowski
- Mats Van Delen
- Mattia I Morandi
- Maurizio Muraca
- Mauro Manno
- Max Piffoux
- Mátyás Bukva
- Md Matiur Rahman
- Md Mostafizur Rahman
- Meadhbh Á Brennan
- Meena Kumari
- Megan I Mitchell
- Mehdi Kabani
- Mehdi Mirzaei
- Mei He
- Meike J Saul
- Melissa K Jones
- Meta J Kuehn
- Metka Lenassi
- Michael P Rimmer
- Michael W Graner
- Michael W Pfaffl
- Michele Zanoni
- Michelle L Pleet
- Migara K Jayasinghe
- Migmar Tsamchoe
- Miguel Flores-Bellver
- Mikael Klingeborn
- Mikhail Skliar
- Miriam Romano
- Miroslava Katsur
- Miroslaw T Kornek
- Mizenko Rachel R.
- Modeline N Longjohn
- Mohammad Rahbari
- Mohanty Sujata
- Mona Batish
- Monika Baj-Krzyworzeka
- Monika Pietrowska
- Möller Andreas
- Muhammad Nawaz
- Muller Fabbri
- Muthuvel Jayachandran
- Myltykbay S Rysmakhanov
- Mỹ G Mahoney
- Nadezhda Nikiforova
- Nadim Tawil
- Namita N Kashyap
- Nandini Asokan
- Naohiro Seo
- Natalia J Krawczynska
- Natalie R Bauer
- Natasa Zarovni
- Natasha S Barteneva
- Nataša Resnik
- Nathaniel Eb Saidu
- Naureen Javeed
- Naveed Akbar
- Navneet Dogra
- Neslihan P Taşlı
- Neta Regev-Rudzki
- Newman Lauren A.
- Nicholas J Peake
- Nicholas R Hoyle
- Nico G Menjivar
- Nicole A Kruh-Garcia
- Nicole Meisner-Kober
- Nicole Noren Hooten
- Nieuwland Rienk
- Nihal Altan-Bonnet
- Nihar Godbole
- Nilufar Ali
- Norman J Haughey
- O'Driscoll Lorraine
- Ochiya Takahiro
- Oksana Kehoe
- Ole Østergaard
- Oleg S Tutanov
- Olesia Gololobova
- Olga Shatnyeva
- Olivier Blanc-Brude
- Olivier Burgy
- Olivier de Wever
- Olivier G de Jong
- Olivier Loudig
- Omar A Osorio
- Onno J Arntz
- Orazio Fortunato
- Orman L Snyder
- Ornella Urzì
- Osamu Takikawa
- Oscar Boyadjian
- Oscar Pb Wiklander
- Oskar Staufer
- Oumaima Stambouli
- Owen G Davies
- Pamali Fonseka
- Paola A Martinez-Murillo
- Paola C Loreto Palacio
- Paola de Candia
- Paolo Bergese
- Paolo Neviani
- Paolo V Fioretti
- Partha K Chandra
- Pascal Colosetti
- Pascale Zimmermann
- Paschalia Pantazi
- Pasquale D'Acunzo
- Patricia M M Ozawa
- Patricia Xander
- Patrick Hölker
- Paul A Haynes
- Paul C Boutros
- Paul D Robbins
- Paul Harrison
- Paula Pincela Lins
- Per Svenningsen
- Peter E Kima
- Peter Nejsum
- Philip D Stahl
- Philippa K Wade
- Pia R-M Siljander
- Pierre Arsène
- Pierre-Yves Mantel
- Pieter Vader
- Pietro Parisse
- Pilar Martin-Duque
- Pingping Han
- Piul S Rabbani
- Qi Hui Poh
- Qiang Chen
- Qin Zhang
- Qing-Ling Fu
- Qiubai Li
- Quan Lu
- Quentin Lemaire
- Quentin Lubart
- Quentin Roux
- Rachel C Quilang
- Rachel E Crossland
- Rachel R Mizenko
- Rafaela F Ferreira
- Raghu Kalluri
- Raghubendra S Dagur
- Rahul Sanwlani
- Ralph Weissleder
- Raluca E Ghebosu
- Ram Sagar
- Ramaroson Andriantsitohaina
- Ramin Khanabdali
- Ramkumar Menon
- Ramon M Eichenberger
- Randy P Carney
- Randy Schekman
- Rane A Harrison
- Raphael Schneider
- Raymond M Schiffelers
- Rebecca A Dragovic
- Rebecca L Davies
- Rebecca Lim
- Reem Bagabas
- Reihaneh Safavi-Sohi
- Renata Chalupská
- René Weiss
- Reza Yarani
- Rezvan Esmaeili
- Riccardo Natoli
- Riccardo Vago
- Richard Chahwan
- Richard Jr Kelwick
- Ridolfi Andrea
- Rienk Nieuwland
- Rikinari Hanayama
- Rita Romani
- Rob Knight
- Robert J Coffey
- Robert L Raffai
- Roberta Palmulli
- Rocío Del Carmen Bravo-Miana
- Rocío Pérez-González
- Roger Olofsson Bagge
- Rohde Eva
- Rojalin Tatu
- Rok Romih
- Rong Xu
- Rossella Crescitelli
- Rowland Andrew
- Rucha Trivedi
- Russell G Rogers
- Rüdiger M Groß
- Ryan C Pink
- Ryou-U Takahashi
- Saara Laitinen
- Sabina Gorska
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- Sachin Shukla
- Saftics Andras
- Sahoo Susmita
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- Sarah Deville
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- Sarah Williams
- Sarai Martinez-Pacheco
- Saravanakumar Murugesan
- Saroj Kumar
- Sasha J Kweskin
- Saugstad Julie A.
- Saumya Das
- Sayam Ghosal
- Scott M Langevin
- Sean M Davidson
- Seiko Ikezu
- Seoyoon Bae
- Serena Cavallero
- Setty M Magaña
- Seung W Oh
- Sébastien Banzet
- Shalini Mishra
- Sharad Kumar
- Sheila Spada
- Shekari Faezeh
- Sherif A Ibrahim
- Shikha Rani
- Shilpa Buch
- Shin-Ichi Kano
- Shirley Potter
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- Shuai Chen
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- Somchai Chutipongtanate
- Sonal Sukreet
- Soo Kim
- Sophie Cavallero
- Sophie Rome
- Soren Jacobsen
- Ssang-Goo Cho
- Stanley M Lemon
- Stanley S Stylli
- Stefan Schneider
- Stefania Raimondo
- Stefano Forte
- Steffi Bosch
- Stella Kourembanas
- Stephanie F Rutter
- Stephanie Jung
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- Stephen Lenzini
- Stephen Redenti
- Steven J Biller
- Steven M Jay
- Stuart Hunt
- Subbaya Subramanian
- Subhadip Ghatak
- Sujan K Mondal
- Sujata Mohanty
- Sukhbir Kaur
- Suman Dutta
- Sun Young Lee
- Suresh Mathivanan
- Surya Shrivastava
- Susann Allelein
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- Syrine Arif
- Tae Ryong Lee
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- Takanori Eguchi
- Tamás Beke-Somfai
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- Tania Limongi
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- Tanina Arab
- Tara Thompson-Felix
- Taral R Lunavat
- Tatiane De Rossi
- Tatu Rojalin
- Tecla Marangon
- Teena Kjb Gamage
- Ter‐Ovanesyan Dmitry
- Thabiso E Motaung
- Thanh Kha Phan
- Theresa L Whiteside
- Théry Clotilde
- Thibaud Dauphin
- Thomas Kislinger
- Thomas Michael Shiju
- Thupten Tsering
- Tiana F Koukoulis
- Tijana Jovanovic-Talisman
- Timothea Konstantinou
- Timothy V Domashevich
- Tine Hiorth Schøyen
- Tobias Tertel
- Tom Ap Driedonks
- Tom G Keulers
- Tommaso Neri
- Tomofumi Yamamoto
- Tong Wang
- Torrecilhas Ana C.
- Tosar Juan P.
- Trude Aspelin
- Tsuneya Ikezu
- Ursula S Sandau
- Useckaite Zivile
- Uta Erdbrügger
- Valentina R Minciacchi
- Valentina Zappulli
- Valeria Barreca
- Valle Francesco
- van der Pol Edwin
- van Herwijnen Martijn J. C.
- Varga Zoltan
- Vasiliki Mahairaki
- Vasiliy S Chernyshev
- Vatsal Deliwala
- Veer Bala Gupta
- Vendula Pospichalova
- Vengala Rao Yenuganti
- Venkatesh Kumar Chetty
- Vera A Tang
- Vera Mugoni
- Vera Tscherrig
- Verity J Ford
- Verline Justilien
- Veronica Huber
- Veronika Kralj-Iglic
- Veronika Stoka
- Victor Bodart-Santos
- Vijaya Sunkara
- Vikramsingh Gujar
- Viktoria Szeifert
- Viktoria Weber
- Vincent Hyenne
- Vincent Yeung
- Vincenza Dolo
- Violaine Moreau
- Vito G D'Agostino
- Vivek Kumar Gupta
- Vladimir Bokun
- Vroniqa Ku'ulei-Lyn Faustino
- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
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- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
- Archer Simon
- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
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- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
- Avery Alison
- Avis Joanne
- Aya Viviana
- Azirar Hanna
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- Bahl Amit
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- Blackwood Geoffrey
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- Bloomfield David
- Bloomfield David
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- Bottomley David
- Bottomley David M
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- Catton Charles N
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- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Hans T
- Chung Peter
- Chung Peter W M
- Churn Mark
- Churn Mark
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- Clarke Noel W
- Clarke Peter
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- Clarke Samantha
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- Clements Colette
- Clements Mia AnnaMaria
- Clitheroe Pat
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- Coffin Teresa
- Cogley Lyn
- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
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- Conroy Ruth
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- Conway Rachel
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- Cook Adrian D
- Cook Audrey
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- Cooper Adele
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- Coppins Helen
- Corbett Thomas B
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- Crellin Perric
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- Cross Vanessa
- Cross William R
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
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- Cunningham Amy
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- Curtis Sandra
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- Dalton-Short Ross
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- Dawson-Athey Linda
- Dayes Ian S
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- Dean Lynsey
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- Downs Nichola
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- Drachenberg Darrel E
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- Griffiths Dorothy
- Griffiths Leyshon
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- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
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- Harding Joshua
- Hardman John
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- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
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- Hathout Lara
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- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heath Catherine M
- Heckford Louise
- Hedges Andy
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- Keng-Koh Pek
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- Malone Shawn C
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- Morris Stephen L
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- Nabid Abdenour
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- Ngumo Alice
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- Ong Aldrich D
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- Parker Chris
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- Petersen Peter M
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- Rodda Sree
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- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
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- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
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- Appleby Rowan
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- Archer Denise
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- Archer Simon
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- Auladin Raidah
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- Cole David J
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- Cook Audrey
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- Cooper Adele
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- Corbett Thomas B
- Corcoran Sam
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- Dayes Ian S
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- Dellar Conor
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- Dodds David
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- Doherty A
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- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
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- E Choan
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- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
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- Gibbins Andrew
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- Glaholm John
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- Griffen Ailsa
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- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
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- Hanna Emma
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- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
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- Harland Keith
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- Harnwell Juliette
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- Harris Catherine
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- Hart Andrew
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- Haskell Annelise
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- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
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- Henson (nee Savidge) Verity
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- Herbert Chris
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- Hocking Christopher
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- Horwich Alan
- Hoskin Peter
- Hoskin Peter
- Hoskins Ashley
- Hoskins Chloe
- Hotine Jodie
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- Hughes Claire
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- Hughes Owen
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- Hughes Simon
- Hughes-Davies Luke
- Hugill Angela
- Hugill Angela
- Humber Caroline
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- Hyde Katherine
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- Hynds Sharon
- Ibrahim Azman
- Ingham Jo
- Ingle Charlotte
- Inman Hayley
- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
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- Jain Suneil
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- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
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- Jelski Joseph
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- Jenkins Suzanne
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- Jepson Debbie
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- Jewers Karen
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- Jones-Skipper Kay
- Jonnada Sai
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- Jose Sanal
- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
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- Kalejaiye Odunayo
- Kaliski Alexandre
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- Kanaga-Sundaram Subramanian
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- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
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- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
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- Kelly Alison
- Kelly Kay
- Kemp Gail
- Kempel Mette Moe
- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
- Kenyon Lucille
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- Khoury Ghassan
- Kiff Janet
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- Kilmartin John
- Kilroy Stephen
- Kilroy Stephen
- Kiltie Anne
- Kiltie Anne
- Kim David
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- Kirkbride Peter
- Kirkbride Peter
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- Kirkpatrick Suriya
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- Klapp Kathi
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- Knapp Jeanette
- Knight (n. Sherburn) Victoria
- Knott Helen
- Knox WF
- Kockelbergh Roger
- Koehler Ingrid
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- Kotze Michelle
- Koul Rashmi
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- Kynaston Howard
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- Lam Jacqueline
- Lambert Carole
- Lambert Katy
- Lamoureux Alexandra
- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
- Larouche Julie
- Larson Beverly
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- Lau Maurice
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- Liu Stanley
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- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
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- Logue John
- Logue John
- Logue John
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- Lokes Rachel
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- Lomas Alia
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- Lydon Anne Marie
- Lynch Rory
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- Macdonald Alison
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- MacGregor Barbara
- Macgregor Carol
- MacIsaac Kathy
- MacIsaac Patricia
- Mackay Rachel
- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
- Madine John
- Magwaro Sophia
- Magwaro Sophia
- Magwaro Sophia
- Mahmood Rana
- Mahmood Rana
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- Mahoney Catriona
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- Maitland Katrina
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- Makepeace Barbara
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- Mallett Debbie
- Malone Shawn
- Malone Shawn C.
- Manetta Caroline
- Manganaro Aileen
- Mangar Stephen
- Maniatis Christos
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- Mardell Stephen
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- Mashegede Beverley
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- Masson Susan
- Masson Susan
- Masters Benjamin
- Masters Lindsey
- Masters Lindsey
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- McCabe Alastair
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- McCaul Damian
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- McClements Jane
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- McCormack Anne
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- McCracken Jillian
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- McCrudden Sylvia
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- McFarlane Jonathan
- McFarlane Victoria
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- McIndoe Sue
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- McKee Dianne
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- McLain-Smith Susan
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- Melcher Lucinda
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- Merrick Richard
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- Mikropoulos Christos
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- Morris Stephen
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- Musunuru Hima Bindu
- Muthukumar Dakshinamoorthy
- Myatt Alison
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- Nabid Abdenour
- Nabid Abdenour
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- Nicholson Alastair
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- Ong Aldrich D.
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- Parmar Mahesh K.B.
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- Parulekar Wendy R.
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- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
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- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
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- Baikady Ravishankar
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- Baillie Kenneth
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- Balaie Morteza
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- Bamford Amy
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- Bariola Ryan
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- Barker Stephanie
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- Baron Rebecca M.
- Barreau Amelie
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- Bart Robert
- Bartholomew Jazz
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- Bashyal Archana
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- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
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- Brunskill Nigel
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- Hall Alistair S
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- Kremling Julius
- Kreß Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
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- Kumar Anand
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- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
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- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2010
- Field of study
A human peroxisome proliferator-activated receptor alpha ligand binding domain (PPARαLBD)-maltose binding protein fusion construct was expressed in Escherichia coli. A codon optimized DNA sequence encoding human PPARαLBD (aa196–468) was synthesized and ligated into the pDEST17 E. coli expression vector downstream of a MBP solubility fusion tag and an intermittent TEV protease cleavage site. Following auto-induction at 28 °C, PPARαLBD protein was purified to electrophoretic homogeneity by a nickel affinity chromatographic step, on-column TEV protease cleavage followed by Sephacryl S200 size exclusion chromatography. The recombinant protein displayed cross-reactivity with goat anti-(human PPARα) polyclonal antibody and was identified as human PPARα by trypic peptide mass finger-printing. The addition of a PPARα specific ligand (fenofibric acid, GW7647 or GW590735) to the growth media significantly stabilized the PPARαLBD structure and enhanced the expression of soluble protein. In-cell ligand binding was examined by monitoring the enhancement of PPARαLBD expression as a function of the concentration of ligand in the growth media. The efficient expression and in-cell assay of the reported PPARαLBD construct make it amenable to high through-put screening assays in drug discovery programs.<br /
KpDsbA redox properties.
- Author
- Publication venue
- Publication date
- Field of study
<p><b>A</b>. Disulfide bond reduction activity of KpDsbA (▲), EcDsbA (■) EcDsbC (●) and a control without enzyme (△) was monitored spectrophotometrically. SeDsbA activity has been published elsewhere [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080210#B43" target="_blank">43</a>]. <b>B</b>. Redox equilibria of KpDsbA with glutathione (GSH/GSSG). <b>C</b>. Determination of the nucleophilic Cys33 (CXXC) pK<sub>a</sub>. The pH-dependent absorbance of the thiolate anion at 240 nm was fitted to the Henderson-Hasselbach equation <b>D</b>. Temperature induced unfolding of oxidized (ox, ■) and reduced (red, □) KpDsbA was determined by far-UV CD spectroscopy, showing that the reduced form is more stable than the oxidized form. </p
Comparison of EcDsbA and SeDsbA.
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- Publication venue
- Publication date
- Field of study
<p><b>A</b>. Structural superposition of EcDsbA (magenta, PDB id: 1FVK) and SeDsbA (blue, PDB Id: 3L9S). N- and C-termini, helices (H1 - 7) and strands (β1-5) are indicated. In addition, surface loops (L1 – L3) predicted to be involved in binding EcDsbB periplasmic loop P2 or substrate are labeled in red. Active site cysteines are shown as orange spheres and the <i>cis</i>Pro motif in the L2 loop is indicated by a yellow star. <b>B</b>. Sequences of EcDsbA loops that bind DsbB (blue/red) or SigA substrate (blue). Homologues with highly conserved loop sequences are shown: <i>S. flexneri</i> (SfDsbA, P52235), <i>S. enterica Typhimurium</i> (SeDsbA E1WE53), <i>C. koseri</i> (CkDsbA, A8AL80), <i>E. cloacae</i> (EnDsbA, E3G5L9), <i>C. sakazakii</i> (CsDsbA, I2ED40) and <i>K. pneumoniae</i> (KpDsbA B5XZJ6). Conserved residues are shown in grey, and variable residues in black.</p
Oligosaccharide recognition and binding to the carbohydrate binding module of AMP-activated protein kinase
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study