Condensed tannin reactivity inhibition by internal rearrangements: Detection by CP-MAS 13C NMR

Tannin extracts were prepared from barks of maritime pine (Pinus maritimus), aleppo pine (Pinus halepensis), Norway spruce (Picea abies) and from a mixture of barks of different pine species (Pinus spp., namely 20% black pine (Pinus thunbergii)+ 30% Scots pine (Pinus sylvestris) + 20% maritime pine (Pinus maritimus) + 10% Aleppo Pine (Pinus halepensis) + 5% Douglas fir (Pseudotsuga menziesii) + 15% Norway spruce (Picea abies)) at a paper mill. The 13C-NMR spectra were carried out from these tannins. Blending systems adhesives were prepared with 5% paraformaldehyde to measure the reactivity by gel time, and to determinate the mechanical resistance by thermomechanical analysis (TMA) and the internal bond strength (IB) according to the European Norm EN-312. The CP MAS 13C NMR bands at 163 ppm and the increase number of smaller bands between 20 and 65 ppm clearly indicate that the extraction of procyanidin-type tannins has been incorrect yielded high relative proportions of catechinic acid structures and diarylpropanol-catechinin acid dimer caused by internal flavonoid rearrangement, and causing the blockage of the C6 and C8 reactive sites, rendering unusable the tannin for wood adhesive applications. Thus, the gel times are very long except for the maritime pine tannin with a value of 51 (s). The TMA analysis gave very low MOE values for almost all the tannin extract samples, except for maritime pine. This situation was confirmed by the IB test. Only maritime pine tannin presented a good mechanical resistance with a value of 0.6 (MPa). Only this sample fulfils the standard requested

Traditional systemic treatment options in advanced low-grade serous ovarian cancer after successful cytoreduction: a systematic review and meta-analysis

Objective: We performed a systematic literature review and a subsequent meta-analysis to compare traditional treatment options, i.e., antihormonal and cytotoxic, in LGSOC. Methods: We conducted a systematic literature review in MEDBASE and MEDLINE between September 2000 and June 2021 for women who received cytotoxic chemotherapy and/or antihormonal treatment after primary cytoreduction due to stage II–IV LGSOC and also at relapse. PFS and OS were calculated depending on the type of their adjuvant treatment. For each endpoint in the meta-analysis, pooled HR was calculated using the random effect model with the inverse variance weighted method. Only primary patients were included in the subsequent meta-analysis due to the small number of studies in the relapsed setting. Results: Five eligible first-line studies were included. Systemic chemotherapy failed to provide a significant OS benefit when compared to no systemic treatment (pooled HR = 1.01, 95% CI [0.79, 1.29]) after successful cytoreduction. Moreover, systemic chemotherapy followed by antihormonal treatment also did not result to a significant PFS or OS benefit when compared to systemic chemotherapy alone (for PSF: pooled HR = 0.59, 95% CI [0.33, 1.04]; for OS: pooled HR = 0.83, 95% CI [0.50, 1.39]). There were insufficient data from studies in the recurrent setting to allow their inclusion in the meta-analysis. Conclusions: In this meta-analysis, we failed to identify a traditional cytotoxic or antihormonal systemic treatment option that was associated with a significant OS or PFS benefit when administered following successful cytoreduction for advanced LGSOC. Prospective randomized studies are urgently warranted to define optimal adjuvant options in this challenging disease

Designation processes and semantic substitutions used by european portuguese children in a vocabulary test

This research study focus on the designation processes and semantic substitutions of each word on the vocabulary sub-task from the language test for children – ABFW, standardized in Brazil and adapted to European Portuguese, as well as the comparison of the results obtained in the two countries, to analyze the relevance of their extensibility to the Portuguese population. Methods: The test was applied to 150 children from 5 to 6 years old, of typical development. The test consists of 9 conceptual categories. Each category consists of different words, which were always assessed in the same sequential order. Results: The sample of this study showed a lower performance only in clothes, places and food semantic categories. All the other categories have outperformed the standard. The categories of vocabulary with higher percentage in the right designation of the words were colors and shapes, animals and toys and music instruments. The categories with a higher percentage of substitution processes, from the reference results, were: food and locations. The most recurrent substitution processes were the co-hyponym, words that designate semantic attributes, valorization of the visual stimulus, hypernym and parasynonyms Conclusion: Given the homogeneity of the results of this study with the results obtained with other studies in Brazil, this test reveal potentiality as an instrument for vocabulary assessment in Portugal.Objetivo: Este estudo teve por objetivo a análise e quantificação dos processos de designação e substituição semântica apresentados na prova do vocabulário do Teste de Linguagem Infantil ABFW, padronizado no Brasil e adaptado para Português Europeu (PE), assim como a comparação dos resultados obtidos nos dois países, de forma a analisar a pertinência da sua extensibilidade à população portuguesa. Métodos: A prova foi aplicada a 150 crianças de 5 e 6 anos de idade, de desenvolvimento típico, na Região Norte de Portugal. A prova é constituída por nove categorias conceituais e cada categoria formada por diferentes vocábulos, que foram avaliados sempre pela mesma ordem sequencial. Resultados: A amostra mostrou desempenho inferior, em relação à norma, apenas nas categorias semânticas vestuário, locais e alimentos. Todas as outras categorias revelaram desempenho superior. As categorias do vocabulário que apresentaram maior percentagem de respostas corretas foram: animais, formas e cores e brinquedos e instrumentos musicais. As categorias que apresentaram percentagem superior de processos de substituição, em relação à norma, foram alimentos e locais. Os processos de substituição mais utilizados foram: substituição por co-hipônimo, vocábulos que designam atributos semânticos, valorização do estímulo visual, hiperônimos e parassinônimos. Conclusão: Dada a homogeneidade dos resultados deste estudo com os resultados obtidos em outros estudos no Brasil, esta prova revela potencialidades como instrumento de avaliação do vocabulário em Portugal.This work is funded by CIEd – Research Centre on Education, projects UID/CED/1661/2013 and UID/CED/1661/2016, Institute of Education, University of Minho, through national funds of FCT/MCTESPT.info:eu-repo/semantics/publishedVersio

Condensed tannin reactivity inhibition by internal rearrangements: Detection by CP-MAS 13C NMR

Tannin extracts were prepared from barks of maritime pine (Pinus maritimus), aleppo pine (Pinus halepensis), Norway spruce (Picea abies) and from a mixture of barks of different pine species (Pinus spp., namely 20% black pine (Pinus thunbergii)+ 30% Scots pine (Pinus sylvestris) + 20% maritime pine (Pinus maritimus) + 10% Aleppo Pine (Pinus halepensis) + 5% Douglas fir (Pseudotsuga menziesii) + 15% Norway spruce (Picea abies)) at a paper mill. The 13C-NMR spectra were carried out from these tannins. Blending systems adhesives were prephe increase number of smaller bands between 20 and 65 ppm clearly indicate that the extraction of procyanidin-type tannins has been incorrect yielded high relative proportions of catechinic acid structures and diarylpropanol-catechinin acid dimer caused by internal flavonoid rearrangement, and causing the blockage of the C6 and C8 reactive sites, rendering unusable the tannin for wood adhesive applications. Thus, the gel times are very long except for the maritime pine tannin with a value of 51 (s). The TMA analysis gave very low MOE values for almost all the tannin extract samples, except for maritime pine. This situation was confirmed by the IB test. Only maritime pine tannin presented a good mechanical resistance with a value of 0.6 (MPa). Only this sample fulfils the standard requested

Crystallisation and preliminary X-ray analysis of PepC, a thiol aminopeptidase from Lactoccocus lactis homologous to bleomycin hydrolase

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Premiers résultats prometteurs de l’essai rapamycine versus placebo pour le traitement de la myosite à inclusions (RAPAMI)

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