Investigation of nonlinear motion simulator washout schemes

An overview is presented of some of the promising washout schemes which have been devised. The four schemes presented fall into two basic configurations; crossfeed and crossproduct. Various nonlinear modifications further differentiate the four schemes. One nonlinear scheme is discussed in detail. This washout scheme takes advantage of subliminal motions to speed up simulator cab centering. It exploits so-called perceptual indifference thresholds to center the simulator cab at a faster rate whenever the input to the simulator is below the perceptual indifference level. The effect is to reduce the angular and translational simulation motion by comparison with that for the linear washout case. Finally, the conclusions and implications for further research in the area of nonlinear washout filters are presented

Social rank overrides environmental and community fluctuations in determining meat access by female chimpanzees in the Taï National Park, Côte d’Ivoire

Meat, long hypothesized as an important food source in human evolution, is still a substantial component of the modern human diet, with some humans relying entirely on meat during certain times of the year. Understanding the socio-ecological context leading to the successful acquisition and consumption of meat by chimpanzees (Pan troglodytes), our closest living relative, can provide insight into the emergence of this trait because humans and chimpanzees are unusual among primates in that they both (i) hunt mammalian prey, (ii) share meat with community members, and (iii) form long-term relationships and complex social hierarchies within their communities. However, females in both human hunter-gatherer societies as well as chimpanzee groups rarely hunt, instead typically accessing meat via males that share meat with group members. In general, female chimpanzee dominance rank affects feeding competition, but so far, the effect of female dominance rank on meat access found different results within and across studied chimpanzee groups. Here we contribute to the debate on how female rank influences meat access while controlling for several socio-ecological variables. Multivariate analyses of 773 separate meat-eating events collected over more than 25 years from two chimpanzee communities located in the Taï National Park, Côte d’Ivoire, were used to test the importance of female dominance rank for being present at, and for acquiring meat, during meat-eating events. We found that high-ranking females were more likely to be present during a meat-eating event and, in addition, were more likely to eat meat compared to the subordinates. These findings were robust to both large demographic changes (decrease of community size) and seasonal ecological changes (fruit abundance dynamics). In addition to social rank, we found that other female properties had a positive influence on presence to meat-eating events and access to meat given presence, including oestrus status, nursing of a small infant, and age. Similar to findings in other chimpanzee populations, our results suggest that females reliably acquire meat over their lifetime despite rarely being active hunters. The implication of this study supports the hypothesis that dominance rank is an important female chimpanzee property conferring benefits for the high-ranking females

Diffuse somatostatin-immunoreactive D-cell hyperplasia in the stomach and duodenum

This paper presents the first case of extensive, diffuse, somatostatin- immunoreactive D-cell hyperplasia in the human stomach and duodenum. It occurred in a 37-yr-old woman, who showed clinical signs of dwarfism, obesity, dryness of the mouth, and goiter. The density of the distribution of D cells was increased 39-fold in the stomach fundus, 23- fold in the proximal antrum, 25-fold in the distal antrum, and 31-fold in the upper duodenum in comparison with normal values. At the same time, the gastrin-immunoreactive cells were increased 2.3-fold in the antrum. Although the range in size of the D cells was within normal limits in all regions examined, the G cells showed pronounced hypertrophy of up to 127%. A possible relationship between the immuno- histochemical findings and the clinical picture is discussed

Bioprocess Development for Lantibiotic Ruminococcin-A Production in Escherichia coli and Kinetic Insights Into LanM Enzymes Catalysis

Ruminococcin-A (RumA) is a peptide antibiotic with post-translational modifications including thioether cross-links formed from non-canonical amino acids, called lanthionines, synthesized by a dedicated lanthionine-generating enzyme RumM. RumA is naturally produced by Ruminococcus gnavus, which is part of the normal bacterial flora in the human gut. High activity of RumA against pathogenic Clostridia has been reported, thus allowing potential exploitation of RumA for clinical applications. However, purifying RumA from R. gnavus is challenging due to low production yields (120 mg L–1 for the chimeric construct and >150 mg L–1 for RumM. The correlation observed between microscale and lab-scale bioreactor cultivations suggests that the process is robust and realistically applicable to industrial-scale conditions.DFG, 53182490, EXC 314: Unifying Concepts in CatalysisDFG, 414044773, Open Access Publizieren 2019 - 2020 / Technische Universität Berli

Young Stars with SALT

We present a spectroscopic and kinematic analysis of 79 nearby M dwarfs in 77 systems. All are low-proper-motion southern hemisphere objects and were identified in a nearby star survey with a demonstrated sensitivity to young stars. Using low-resolution optical spectroscopy from the Red Side Spectrograph (RSS) on the South African Large Telescope (SALT), we have determined radial velocities, H-alpha, Lithium 6708\AA, and Potassium 7699\AA~equivalent widths linked to age and activity, and spectral types for all our targets. Combined with astrometric information from literature sources, we identify 44 young stars. Eighteen are previously known members of moving groups within 100 parsecs of the Sun. Twelve are new members, including one member of the TW Hydra moving group, one member of the 32 Orionis moving group, nine members of Tucana-Horologium, one member of Argus, and two new members of AB Doradus. We also find fourteen young star systems that are not members of any known groups. The remaining 33 star systems do not appear to be young. This appears to be evidence of a new population of nearby young stars not related to the known nearby young moving groups.Comment: 23 pages, 11 figures, 6 tables. Accepted to Ap

The Potential of Polyhydroxyalkanoate Production from Food Wastes

Background and objective: Over 1 billion tons of foods are wasted every year (not consumed by humans or animals). Most of this waste ends up in landfills. As the global population increases, mankind must look for more sustainable means of living. A recently popular idea is the use of organic wastes as carbon feedstocks for fermentation that produces value added products. Polyhydroxyalkanoates are a family of bio-based, biodegradable polymers that can be produced in large quantities using food and food processing wastes as the main feedstocks. In many cases, biocatalysts have been engineered to efficiently use these waste compounds to produce large quantities of useful intracellular polyhydroxyalkanoates.Results and conclusion: In the current study, various polyhydroxyalkanoates were produced; each with different thermal and mechanical characteristics useful for different applications. If polyhydroxyalkanoate production facilities are established next to food waste accumulation sites (e.g., large landfills), potentials for the economical and sustainable polyhydroxyalkanoate production sound promising.Conflict of interest: The authors declare no conflict of interest

Universal schema for entity type prediction

Categorizing entities by their types is useful in many applications, including knowledge base construction, relation extraction and query intent prediction. Fine-grained entity type ontologies are especially valuable, but typically difficult to design because of unavoidable quandaries about level of detail and boundary cases. Automatically classifying entities by type is challenging as well, usually involving hand-labeling data and training a supervised predictor. This paper presents a universal schema approach to fine-grained entity type prediction. The set of types is taken as the union of textual surface patterns (e.g. appositives) and pre-defined types from available databases (e.g. Freebase) - yielding not tens or hundreds of types, but more than ten thousands of entity types, such as financier, criminologist, and musical trio. We robustly learn mutual implication among this large union by learning latent vector embeddings from probabilistic matrix factorization, thus avoiding the need for hand-labeled data. Experimental results demonstrate more than 30% reduction in error versus a traditional classification approach on predicting fine-grained entities types. © 2013 ACM

Enriching Knowledge Bases with Counting Quantifiers

Information extraction traditionally focuses on extracting relations between identifiable entities, such as . Yet, texts often also contain Counting information, stating that a subject is in a specific relation with a number of objects, without mentioning the objects themselves, for example, "California is divided into 58 counties". Such counting quantifiers can help in a variety of tasks such as query answering or knowledge base curation, but are neglected by prior work. This paper develops the first full-fledged system for extracting counting information from text, called CINEX. We employ distant supervision using fact counts from a knowledge base as training seeds, and develop novel techniques for dealing with several challenges: (i) non-maximal training seeds due to the incompleteness of knowledge bases, (ii) sparse and skewed observations in text sources, and (iii) high diversity of linguistic patterns. Experiments with five human-evaluated relations show that CINEX can achieve 60% average precision for extracting counting information. In a large-scale experiment, we demonstrate the potential for knowledge base enrichment by applying CINEX to 2,474 frequent relations in Wikidata. CINEX can assert the existence of 2.5M facts for 110 distinct relations, which is 28% more than the existing Wikidata facts for these relations.Comment: 16 pages, The 17th International Semantic Web Conference (ISWC 2018

Understanding of the phase transformation from fullerite to amorphous carbon at the microscopic level

We have studied the shock-induced phase transition from fullerite to a dense amorphous carbon phase by tight-binding molecular dynamics. For increasing hydrostatic pressures P, the C60-cages are found to polymerise at P<10 GPa, to break at P~40 GPa and to slowly collapse further at P>60 GPa. By contrast, in the presence of additional shear stresses, the cages are destroyed at much lower pressures (P<30 GPa). We explain this fact in terms of a continuum model, the snap-through instability of a spherical shell. Surprisingly, the relaxed high-density structures display no intermediate-range order.Comment: 5 pages, 3 figure