Drivers of land use change and household determinants of sustainability in smallholder farming systems of Eastern Uganda

Smallholder farming systems in sub-Saharan Africa have undergone changes in land use, productivity and sustainability. Understanding of the drivers that have led to changes in land use in these systems and factors that influence the systems’ sustainability is useful to guide appropriate targeting of intervention strategies for improvement. We studied low input Teso farming systems in eastern Uganda from 1960 to 2001 in a place-based analysis combined with a comparative analysis of similar low input systems in southern Mali. This study showed that policy-institutional factors next to population growth have driven land use changes in the Teso systems, and that nutrient balances of farm households are useful indicators to identify their sustainability. During the period of analysis, the fraction of land under cultivation increased from 46 to 78%, and communal grazing lands nearly completely disappeared. Cropping diversified over time; cassava overtook cotton and millet in importance, and rice emerged as an alternative cash crop. Impacts of political instability, such as the collapse of cotton marketing and land management institutions, of communal labour arrangements and aggravation of cattle rustling were linked to the changes. Crop productivity in the farming systems is poor and nutrient balances differed between farm types. Balances of N, P and K were all positive for larger farms (LF) that had more cattle and derived a larger proportion of their income from off-farm activities, whereas on the medium farms (MF), small farms with cattle (SF1) and without cattle (SF2) balances were mostly negative. Sustainability of the farming system is driven by livestock, crop production, labour and access to off-farm income. Building private public partnerships around market-oriented crops can be an entry point for encouraging investment in use of external nutrient inputs to boost productivity in such African farming systems. However, intervention strategies should recognise the diversity and heterogeneity between farms to ensure efficient use of these external inputs

Impacts of heterogeneity in soil fertility on legume-finger millet productivity, farmers ' targeting and economic benefits

Targeting of integrated management practices for smallholder agriculture in sub-Saharan Africa is necessary due to the great heterogeneity in soil fertility. Experiments were conducted to evaluate the impacts of landscape position and field type on the biomass yield, N accumulation and N2-fixation by six legumes (cowpea, green gram, groundnut, mucuna, pigeonpea and soyabean) established with and without P during the short rain season of 2005. Residual effects of the legumes on the productivity of finger millet were assessed for two subsequent seasons in 2006 in two villages in Pallisa district, eastern Uganda. Legume biomass and N accumulation differed significantly (P <0.001) between villages, landscape position, field type and P application rate. Mucuna accumulated the most biomass (4.8–10.9 Mg ha-1) and groundnut the least (1.0–3.4 Mg ha-1) on both good and poor fields in the upper and middle landscape positions. N accumulation and amounts of N2-fixed by the legumes followed a similar trend as biomass, and was increased significantly by application of P. Grain yields of finger millet were significantly (P <0.001) higher in the first season after incorporation of legume biomass than in the second season after incorporation. Finger millet also produced significantly more grain in good fields (0.62–2.15 Mg ha-1) compared with poor fields (0.29–1.49 Mg ha-1) across the two villages. Participatory evaluation of options showed that farmers preferred growing groundnut and were not interested in growing pigeonpea and mucuna. They preferentially targeted grain legumes to good fields except for mucuna and pigeonpea which they said they would grow only in poor fields. Benefit-cost ratios indicated that legume-millet rotations without P application were only profitable on good fields in both villages. We suggest that green gram, cowpea and soyabean without P can be targeted to good fields on both upper and middle landscape positions in both villages. All legumes grown with P fertiliser on poor fields provided larger benefits than continuous cropping of millet

Modelling of a micro Coriolis mass flow sensor for sensitivity improvement

We have developed a multi-axis flexible body model with which we can investigate the behavior of (micro) Coriolis mass flow sensors with arbitrary channel geometry. The model has been verified by measurements on five different designs of micro Coriolis mass flow sensors. The model predicts the Eigen frequency of the first two modes within 10% when the sensor tube is filled with air, water or iso-propyl alcohol. The complex shape and high aspect ratio of the micro channels do not allow conventional FEM modelling. Instead the Matlab package SPACAR is used, which allows to model the sensor with a limited number of elements, providing fast and accurate numerical computations. This allows optimization of channel geometry and positioning of the sensing structures. The model can also be applied to other resonating structures

Radiative ballistic phonon transport in silicon-nitride membranes at low temperatures

We studied the phonon transport in free-standing 1 µm thick silicon-nitride membranes at temperatures around 100 mK. By varying the geometry of the membranes and the dimensions of the heater element, we are able to distinguish between radiative and diffuse phonon transport. The data indicate that the transport is radiative ballistic with a lower limit to a phonon mean-free path of about 1 mm and that the probability for specular reflection from the surface is at least 0.99. The tested silicon-nitride membranes were grown on Si(100), Si(110), and polycrystalline-Si and the transport properties show no dependency on the substrat

Efficacy of nutrient management options for finger millet production on degraded smallholder farms in eastern Uganda

Open Access Journal; Published online: 30 Sep 2021Poor soil fertility is a major problem constraining crop productivity in smallholder farms of sub-Saharan Africa due to inadequate nutrient replenishment. Differential management of nutrients creates areas of accumulation and depletion of nutrients within farms with the latter increasing in spatial coverage. Nutrient additions are required to increase crop production in such degraded areas. We used experimental data to evaluate the potential of inorganic fertilizers and organic manures to offset finger millet yield differences or gap between degraded fields and former kraals, which are recognized as niches for obtaining the best yields within the Teso farming system in eastern Uganda. Nitrogen (N) and phosphorus (P) fertilizers were sole applied at 0, 30, 60, and 90 kg ha−1 and in combination (N+P) at equal rates of sole application, and manure (3 t ha−1) supplemented with N (0, 30, 60, and 90 kg ha−1) to degraded fields located in upper and middle landscape positions in Chelekura and Onamudian villages. A second control treatment of finger millet grown on soils of former kraal sites (high fertility niches) was included as a benchmark to evaluate the efficacy of nutrient management options on degraded field. Average grain yield ranged from 404 to 2,026 kg ha−1 and differed significantly (p < 0.001) between villages and seasons. Significant effects (p < 0.05) of landscape position on grain yield were observed only in Onamudian village. Although the treatments significantly increased millet yields on degraded fields above the control, they could not eliminate the yield differences between degraded fields and former kraals. The largest average grain yields on degraded fields were obtained from combined application of N+P resulting in average grain yields of 800 and 1,171 kg ha−1 in Chelekura village and Onamudian village, respectively. These yield responses resulted in only 24 and 43% of yields obtained on former kraal fields in Chelekura and Onamudian, respectively. The physiological efficiencies, agronomic efficiencies, and apparent recoveries of N and P were low; often <25%. Pot experiments conducted in a greenhouse showed that Sulphur (S) and potassium (K) were additional limiting nutrients to N and P for finger millet production in Chelekura and Onamudian and may partly explain the large yield differences of finger millet between fertilized fields and former kraals in the smallholder farming systems. Nutrient management strategies for sustainable millet production in these farming systems need consideration of site-specific nutrient limitations

Loss of SLCO1B3 drives taxane resistance in prostate cancer

Background: Both taxanes, docetaxel and cabazitaxel, are effective treatments for metastatic castration-resistant prostate cancer (mCRPC). However, resistance to taxanes is common. Our objective was to investigate mechanisms of taxane resistance in prostate cancer. Methods: Two docetaxel-resistant patient-derived xenografts (PDXs) of CRPC were established (PC339-DOC and PC346C-DOC) in male athymic nude mice by frequent intraperitoneal administrations of docetaxel. Next-generation sequencing was performed on PDX tissue pre- and post-docetaxel resistance and gene expression profiles were compared. [14C]-docetaxel and [14C]-cabazitaxel uptake assays in vitro and cytotoxicity assays were performed to validate direct involvement of transporter genes in taxane sensitivity. Results: Organic anion-transporting polypeptide (SLCO1B3), an influx transporter of docetaxel, was significantly downregulated in PC346C-DOC tumours. In accordance with this finding, intratumoural concentrations of docetaxel and cabazitaxel were significantly decreased in PC346C-DOC as compared with levels in chemotherapy-naive PC346C tumours. In addition, silencing of SLCO1B3 in chemo-naive PC346C resulted in a two-fold decrease in intracellular concentrations of both taxanes. Overexpression of SLCO1B3 showed higher sensitivity to docetaxel and cabazitaxel. Conclusions: The SLCO1B3 determines intracellular concentrations of docetaxel and cabazitaxel and consequently influences taxane efficacy. Loss of the drug transporter SLCO1B3 may drive taxane resistance in prostate cancer

Effect of atrial fibrillation on endovascular thrombectomy for acute ischemic stroke. A meta-analysis of individual patient data from six randomised trials: Results from the HERMES collaboration

Background: Atrial fibrillation is an important risk factor for ischemic stroke, and is associated with an increased risk of poor outcome after ischemic stroke. Endovascular thrombectomy is safe and effective in acute ischemic stroke patients with large vessel occlusion of the anterior circulation. This meta-analysis aims to investigate whether there is an interaction between atrial fibrillation and treatment effect of endovascular thrombectomy, and secondarily whether atrial fibrillation is associated with worse outcome in patients with ischemic stroke due to large vessel occlusion. Methods: Individual patient data were from six of the recent randomised clinical trials (MR CLEAN, EXTEND-IA, REVASCAT, SWIFT PRIME, ESCAPE, PISTE) in which endovascular thrombectomy plus standard care was compared to standard care alone. Primary outcome measure was the shift on the modified Rankin scale (mRS) at 90 days. Secondary outcomes were functional independence (mRS 0–2) at 90 days, National Institutes of Health Stroke Scale score at 24 h, symptomatic intracranial hemorrhage and mortality at 90 days. The primary effect parameter was the adjusted common odds ratio, estimated with ordinal logistic regression (shift analysis); treatment effect modification of atrial fibrillation was assessed with a multiplicative interaction term. Results: Among 1351 patients, 447 p

Observation of isolated high-E_T photons in deep inelastic scattering

First measurements of cross sections for isolated prompt photon production in deep inelastic ep scattering have been made using the ZEUS detector at the HERA electron-proton collider using an integrated luminosity of 121 pb^-1. A signal for isolated photons in the transverse energy and rapidity ranges 5 < E_T^gamma < 10 GeV and -0.7 < eta^gamma < 0.9 was observed for virtualities of the exchanged photon of Q^2 > 35 GeV^2. Cross sections are presented for inclusive prompt photons and for those accompanied by a single jet in the range E_T^jet \geq 6 GeV and -1.5 \leq eta^jet < 1.8. Calculations at order alpha^3alpha_s describe the data reasonably well.Comment: 16 pages, 5 figure

The role of coping strategies in quality of life of adolescents with asthma

This study aimed to determine which coping strategies are associated with better quality of life (QOL) in adolescents with asthma. Furthermore, because coping can mediate the effects of health stressors on QOL, this study also examined the indirect effect of asthma severity on QOL via coping. Between January and May 2003, 553 Dutch adolescents with asthma (aged 12–6 years) completed questionnaires assessing coping strategies, symptom severity, overall QOL and positive QOL domain (positive effects of asthma domain). The relations between symptom severity, coping strategies and QOL were tested with structural equation modelling (SEM). Symptom severity affected overall and positive QOL, both directly and indirectly via coping. The coping strategies restricted lifestyle and worrying about asthma were associated with poorer overall QOL. The use of the coping strategies restricted lifestyle, positive reappraisal, and information seeking was related to increased scores on the positive QOL domain, whereas hiding asthma was related to lower scores on the positive QOL domain

Intraoperative Assessment of the Resection Specimen Facilitates Achievement of Adequate Margins in Oral Carcinoma

Background: Inadequate resection margins in oral cavity squamous cell carcinoma have an adverse effect on patient outcome. Intraoperative assessment provides immediate feedback enabling the surgeon to achieve adequate resection margins. The goal of this study was to evaluate the value of specimen-driven intraoperative assessment by comparing the margin status in the period before and the period after the introduction of specimen-driven assessment as a standard of care (period 2010–2012 vs period 2013–2017). Methods: A cohort of patients surgically treated for oral squamous cell carcinoma at the Erasmus MC Cancer Institute, Rotterdam, between 2010–2012 was studied retrospectively and compared to results of a prospectively collected cohort between 2013–2017. The frequency, type and results of intraoperative assessment of resection margins were analyzed. Results: One hundred seventy-four patients were included from 2010–2012, 241 patients were included from 2013–2017. An increase in the frequency of specimen-driven assessment was seen between the two periods, from 5% in 2010–2012 to 34% in 2013–2017. When performing specimen-driven assessment, 16% tumor-positive resection margins were found in 2013–2017, compared to 43% tumor-positive resection margins overall in 2010–2012. We found a significant reduction of inadequate resection margins for specimen-driven intraoperative assessment (p < 0.001). Also, tumor recurrence significantly decreased, and dise