Eigensystem realization algorithm modal identification experiences with mini-mast

This paper summarizes work performed under a collaborative research effort between the National Aeronautics and Space Administration (NASA) and the German Aerospace Research Establishment (DLR, Deutsche Forschungsanstalt fur Luft- und Raumfahrt). The objective is to develop and demonstrate system identification technology for future large space structures. Recent experiences using the Eigensystem Realization Algorithm (ERA), for modal identification of Mini-Mast, are reported. Mini-Mast is a 20 m long deployable space truss used for structural dynamics and active vibration-control research at the Langley Research Center. A comprehensive analysis of 306 frequency response functions (3 excitation forces and 102 displacement responses) was performed. Emphasis is placed on two topics of current research: (1) gaining an improved understanding of ERA performance characteristics (theory vs. practice); and (2) developing reliable techniques to improve identification results for complex experimental data. Because of nonlinearities and numerous local modes, modal identification of Mini-Mast proved to be surprisingly difficult. Methods were available, ERA, for obtaining detailed, high-confidence results

The Burial and Best Intentions: Marinello One-Acts

Two one-act plays presented at John Carroll University in February of 2000.https://collected.jcu.edu/plays/1121/thumbnail.jp

PanGraph: scalable bacterial pan-genome graph construction

The genomic diversity of microbes is commonly parameterized as SNPs relative to a reference genome of a well-characterized, but arbitrary, isolate. However, any reference genome contains only a fraction of the microbial pangenome, the total set of genes observed in a given species. Reference-based approaches are thus blind to the dynamics of the accessory genome, as well as variation within gene order and copy number. With the widespread usage of long-read sequencing, the number of high-quality, complete genome assemblies has increased dramatically. In addition to pangenomic approaches that focus on the variation in the sets of genes present in different genomes, complete assemblies allow investigations of the evolution of genome structure and gene order. This latter problem, however, is computationally demanding with few tools available that shed light on these dynamics. Here, we present PanGraph, a Julia-based library and command line interface for aligning whole genomes into a graph. Each genome is represented as a path along vertices, which in turn encapsulate homologous multiple sequence alignments. The resultant data structure succinctly summarizes population-level nucleotide and structural polymorphisms and can be exported into several common formats for either downstream analysis or immediate visualization

Usability and feasibility of consumer-facing technology to reduce unsafe medication use by older adults

Background Mobile health technology can improve medication safety for older adults, for instance, by educating patients about the risks associated with anticholinergic medication use. Objective This study's objective was to test the usability and feasibility of Brain Buddy, a consumer-facing mobile health technology designed to inform and empower older adults to consider the risks and benefits of anticholinergics. Methods Twenty-three primary care patients aged ≥60 years and using anticholinergic medications participated in summative, task-based usability testing of Brain Buddy. Self-report usability was assessed by the System Usability Scale and performance-based usability data were collected for each task through observation. A subset of 17 participants contributed data on feasibility, assessed by self-reported attitudes (feeling informed) and behaviors (speaking to a physician), with confirmation following a physician visit. Results Overall usability was acceptable or better, with 100% of participants completing each Brain Buddy task and a mean System Usability Scale score of 78.8, corresponding to “Good” to “Excellent” usability. Observed usability issues included higher rates of errors, hesitations, and need for assistance on three tasks, particularly those requiring data entry. Among participants contributing to feasibility data, 100% felt better informed after using Brain Buddy and 94% planned to speak to their physician about their anticholinergic related risk. On follow-up, 82% reported having spoken to their physician, a rate independently confirmed by physicians. Conclusion Consumer-facing technology can be a low-cost, scalable intervention to improve older adults’ medication safety, by informing and empowering patients. User-centered design and evaluation with demographically heterogeneous clinical samples uncovers correctable usability issues and confirms the value of interventions targeting consumers as agents in shared decision making and behavior change

Fano hypersurfaces and Calabi-Yau supermanifolds

In this paper, we study the geometrical interpretations associated with Sethi's proposed general correspondence between N = 2 Landau-Ginzburg orbifolds with integral \hat{c} and N = 2 nonlinear sigma models. We focus on the supervarieties associated with \hat{c} = 3 Gepner models. In the process, we test a conjecture regarding the superdimension of the singular locus of these supervarieties. The supervarieties are defined by a hypersurface \widetilde{W} = 0 in a weighted superprojective space and have vanishing super-first Chern class. Here, \widetilde{W} is the modified superpotential obtained by adding as necessary to the Gepner superpotential a boson mass term and/or fermion bilinears so that the superdimension of the supervariety is equal to \hat{c}. When Sethi's proposal calls for adding fermion bilinears, setting the bosonic part of \widetilde{W} (denoted by \widetilde{W}_{bos}) equal to zero defines a Fano hypersurface embedded in a weighted projective space. In this case, if the Newton polytope of \widetilde{W}_{bos} admits a nef partition, then the Landau-Ginzburg orbifold can be given a geometrical interpretation as a nonlinear sigma model on a complete intersection Calabi-Yau manifold. The complete intersection Calabi-Yau manifold should be equivalent to the Calabi-Yau supermanifold prescribed by Sethi's proposal.Comment: 24 pages, uses JHEP3.cls; v2: minor corrections, references adde

Making a Case for Multi-Disciplinary Analysis

In recent years, I have been drawn to inter-disciplinary approaches to scholarship. Specifically, I have been attracted to “mind studies”—an alluring amalgam of Cognitive Science, Neuroscience, Developmental Psychology, Psychoanalysis, Social Psychology, and Anthropology—as offering more satisfying explanations of human action. In this paper I want to explore more deeply and expound further upon the benefits of multi-disciplinary research. To do so, I’ve invited colleagues of mine who work in other disciplines to view an ethnographic film about a poor Appalachian family and to identify specific issues in it that they would develop further in their classes. My working assumption is that there will be significant variations in what each of us highlights due to differences in the ways we were trained, and that much can be gained pedagogically in assessing the results. In bringing to light some of the limitations of academic overspecialization, the paper hopes to encourage all scholars to venture across disciplinary boundaries more often

Rephasing Ion Packets in the Orbitrap Mass Analyzer to Improve Resolution and Peak Shape

A method is described to improve resolution and peak shape in the Orbitrap under certain experimental conditions. In these experiments, an asymmetric anharmonic axial potential was first produced in the Orbitrap by detuning the voltage on the compensator electrode, which results in broad and multiply split mass spectral peaks. An AC waveform applied to the outer electrode, 180° out of phase with ion axial motion and resonant with the frequency of ion axial motion, caused ions of a given m/z to be de-excited to the equator (z = 0) and then immediately re-excited. This process, termed “rephasing,” leaves the ion packet with a narrower axial spatial extent and frequency distribution. For example, when the Orbitrap axial potential is thus anharmonically de-tuned, a resolution of 124,000 to 171,000 is obtained, a 2- to 3-fold improvement over the resolution of 40,000 to 60,000 without rephasing, at 10 ng/μL reserpine concentration. Such a rephasing capability may ultimately prove useful in implementing tandem mass spectrometry (MS/MS) in the Orbitrap, bringing the Orbitrap\u27s high mass accuracy and resolution to bear on both the precursor and product ions in the same MS/MS scan and making available the collision energy regime of the Orbitrap, ∼1500 eV

Rephasing Ion Packets in the Orbitrap Mass Analyzer to Improve Resolution and Peak Shape

A method is described to improve resolution and peak shape in the Orbitrap under certain experimental conditions. In these experiments, an asymmetric anharmonic axial potential was first produced in the Orbitrap by detuning the voltage on the compensator electrode, which results in broad and multiply split mass spectral peaks. An AC waveform applied to the outer electrode, 180° out of phase with ion axial motion and resonant with the frequency of ion axial motion, caused ions of a given m/z to be de-excited to the equator (z = 0) and then immediately re-excited. This process, termed “rephasing,” leaves the ion packet with a narrower axial spatial extent and frequency distribution. For example, when the Orbitrap axial potential is thus anharmonically de-tuned, a resolution of 124,000 to 171,000 is obtained, a 2- to 3-fold improvement over the resolution of 40,000 to 60,000 without rephasing, at 10 ng/μL reserpine concentration. Such a rephasing capability may ultimately prove useful in implementing tandem mass spectrometry (MS/MS) in the Orbitrap, bringing the Orbitrap\u27s high mass accuracy and resolution to bear on both the precursor and product ions in the same MS/MS scan and making available the collision energy regime of the Orbitrap, ∼1500 eV