An application to select collaborative project management software tools

"The 2014 World Conference on Information Systems and Technologies (WorldCIST'14)"In an increasingly competitive market the use of project management techniques can help controlling scope, time, and cost in an efficient way. Either due to size or complexity that may exist in a project, it may be essential to use project management software tools. Some projects involve teams of people who may be geographically dispersed, being essential to exchange information among project stakeholders, hence the need for collaborative tools, best known as groupware. In this paper, we present an overview of project management and collaborative project management techniques and tools. Next, we present a framework, based on ISO 9126 and ISO 14598, to classify collaborative project management software tools. Finally, we present a model and an application to help on the selection of this type of tools.info:eu-repo/semantics/publishedVersio

An empirical study on the estimation of size and complexity of software applications with function points analysis

Empirical studies are important in software engineering to evaluate new tools, techniques, methods and technologies in a structured way before they are introduced in the industrial (real) software process. Perform empirical studies in a real context is very difficult due to various obstacles. An interesting alternative is perform empirical studies in an educational context using students as subjects and share the results with the academia and the industry. This paper describes a case study with two teams that developed a software system (Web application) for a real customer. In this study we used a model based on Function Points Analysis (FPA) to estimate the size and complexity of software system

Development of a self-diagnostic system integrated into a cyber-physical system

CONTROLAR provides Bosch with an intelligent functional testing machine used to test the correct functioning of the car radios produced. During this process, the radios are submitted to several tests, raising the problem of how the machine detects errors in several radios consecutively, making it impossible to know if the device has a problem since it has no module to see if it works correctly. This article arises from the need to find a solution to solve this problem, which was to develop a self-diagnostic system that will ensure the reliability and integrity of the cyber-physical system, passing a detailed state of the art. The development of this system was based on the design of an architecture that combines the KDT methodology with a DSL to manage and configure the tests to integrate the self-diagnostic test system into a CPS. A total of 28 test cases were performed to cover all its functionalities. The results show that all test cases passed. Therefore, the system meets all the proposed objectives.This article is a result of the project POCI-01-0247-FEDER-040130, supported by Operational Program for Competitiveness and Internationalization (COMPETE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)

Effect of laser heat treatments on the hardness of tool steels

The application of laser heat treatments (LHT) has been growing attention in the last years, due to the effectiveness of localized hardening that can improve the tribological properties of steels. AISI P20 mod. steel is commonly used for plastic injection moulds applications and can be heat-treated to achieve high hardness values. This work presents an experimental investigation on the laser local heat treatments effect on the hardness of AISI P20 mod. steel parts, using a high-power diode laser. Different heat treatments at 1060 ºC and 1100 ºC using a feed rate of 10 mm·s-1 and 15 mm·s-1 were applied on the steel. The LHT were assessed through the hardness mapping trough depth and width. The results showed that the hardness of asreceived P20 mod. tool steel is approximately 300 HV, and after LHT occurred an increment to around 625 HV with a fair hardness distribution. LHT had a minimum of 0.8mm and a maximum of 1.0mm depth.publishe

A Systematic Review and Meta-Analysis

Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder manifesting as lifelong deficits in social communication and interaction, as well as restricted repetitive behaviors, interests and activities. While there are no specific pharmacological or other physical treatments for autism, in recent years repetitive Transcranial Magnetic Stimulation (rTMS), a technique for non-invasive neuromodulation, has attracted interest due to potential therapeutic value. Here we report the results of a systematic literature review and meta-analysis on the use of rTMS to treat ASD. Methods: We performed a systematic literature search on PubMed, Web of Science, Science Direct, Bielefeld Academic Search, and Educational Resources Information Clearinghouse. Search terms reflected diagnoses and treatment modalities of interest. Studies reporting use of rTMS to treat core ASD or cognitive symptoms in ASD were eligible. Two researchers performed article selection and data extraction independently, according to PRISMA guidelines. Changes in ASD clinical scores or in cognitive performance were the main outcomes. Random effects meta-analysis models were performed. Results: We found 23 eligible reports, comprising 4 case-reports, 7 non-controlled clinical trials, and 12 controlled clinical trials, comparing the effects of real TMS with waiting-list controls (n = 6) or sham-treatment (n = 6). Meta-analyses showed a significant, but moderate, effect on repetitive and stereotyped behaviors, social behavior, and number of errors in executive function tasks, but not other outcomes. Most studies had a moderate to high risk of bias, mostly due to lack of subject- and evaluator-blinding to treatment allocation. Only 5 studies reported stability of these gains for periods of up 6 months, with descriptions that improvements were sustained over time. Conclusions: Existing evidence supports that TMS could be useful to treat some dimensions of ASD. However, such evidence must be regarded with care, as most studies did not adequately control for placebo effects. Moreover, little is known regarding the most effective stimulation parameters, targets, and schedules. There is an urgent need for further randomized, double-blind, sham-controlled trials, with adequate follow-up periods, to test the efficacy of transcranial magnetic stimulation to treat these disorders. Available evidence must be regarded as preliminary and insufficient, at present, to support offering TMS to treat ASD.publishersversionpublishe

The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure

OBJECTIVE: Bacillus Calmette-Guérin (BCG) immunotherapy is the gold standard treatment for superficial bladder tumors with intermediate/high risk of recurrence or progression. However, approximately 30% of patients fail to respond to the treatment. Effective BCG therapy needs precise activation of the type 1 helper cells immune pathway. Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phenotype and may directly interfere with the BCG-induced antitumor immune response. Thus, we aim to clarify the influence of TAMs, in particular of the M2 phenotype in stroma and tumor areas, in BCG treatment outcome. PATIENTS AND METHODS: The study included 99 patients with bladder cancer treated with BCG. Tumors resected before treatment were evaluated using immunohistochemistry for CD68 and CD163 antigens, which identify a lineage macrophage marker and a M2-polarized specific cell surface receptor, respectively. CD68+ and CD163+ macrophages were evaluated within the stroma and tumor areas, and high density of infiltrating cells spots were selected for counting. Hypoxia, an event known to modulate macrophage phenotype, was also assessed through hypoxia induced factor (HIF)-1α expression. RESULTS: Patients in whom BCG failed had high stroma-predominant CD163+ macrophage counts (high stroma but low tumor CD163+ macrophages counts) when compared with the ones with a successful treatment (71% vs. 47%, P = 0.017). Furthermore, patients presenting this phenotype showed decreased recurrence-free survival (log rank, P = 0.008) and a clear 2-fold increased risk of BCG treatment failure was observed in univariate analysis (hazard ratio = 2.343; 95% CI: 1.197-4.587; P = 0.013). Even when adjusted for potential confounders, such as age and therapeutic scheme, multivariate analysis revealed 2.6-fold increased risk of recurrence (hazard ratio = 2.627; 95% CI: 1.340-5.150; P = 0.005). High stroma-predominant CD163+ macrophage counts were also associated with low expression of HIF-1α in tumor areas, whereas high counts of CD163+ in the tumor presented high expression of HIF-1α in tumor nests. CONCLUSIONS: TAMs evaluation using CD163 is a good indicator of BCG treatment failure. Moreover, elevated infiltration of CD163+ macrophages, predominantly in stroma areas but not in the tumor, may be a useful indicator of BCG treatment outcome, possibly owing to its immunosuppressive phenotype