Efektivitas Preventif Omeprazol Terhadap Efek Samping Tukak Lambung Antiinflamasi Non Steroid (Asetosal) pada Tikus Galur Wistar Betina

Obat antiinflamasi non steroid (OAINS) memiliki efek samping utama dalam penggunaan berulang, yaitu tukak lambung. Penggunaan OAINS dengan dosis tinggi (dosis anti rematik artritis) meningkatkan resiko terkenanya tukak lambung. Pemberian obat anti tukak lambung seperti omeprazol dapat mengobati dan mencegah tukak lambung. Penelitian ini bertujuan untuk mengetahui efektivitas preventif omeprazol terhadap efek samping tukak lambung OAINS, asetosal pada dosis anti rematik artritis. Efektivitas preventif omeprazol ditentukan secara in vivo pada tikus galur Wistar betina. Tikus dibagi menjadi kelompok yang mendapat OAINS uji (asetosal) pada dosis anti rematik artritis saja dan kelompok yang mendapat omeprazol sebagai terapi preventif, kemudian diberikan asetosal pada dosis anti rematik artritis. Perlakuan diberikan selama tujuh hari, kemudian tukak lambung yang terjadi dievaluasi menggunakan skor jumlah tukak, keparahan tukak dan persen kejadian tukak lambung, dan dibandingkan antar kelompok perlakuan secara statistik. Dihitung indeks tukak tiap klompok untuk menilai tingkat tukak lambung yang terjadi. Hasil penelitian menunjukkan, efektivitas preventif omeprazol terhadap efek samping tukak lambung dari asetosal adalah sebesar 10,68 %.Kata kunci: OAINS, asetosal, efek samping, indek tukak. Non steroidal anti-inflammatory drugs (NSAIDs) have prominent side effect in repeated use, peptic ulcer. Indication of NSAIDs in high dose (rheumatic arthritis' dose) increase the risk of peptic ulcer. Administration of antipeptic ulcer medicine-omeprazol could prevent and healing peptic ulcer. The aim of this study was to observe the effectivity of omeprazol's prevention to peptic ulcer side effect of NSAIDs, asetosal in rheumatic arthritis' dose. The effectivity of omeprazol's prevention determined in vivo in female Wistar rats. Rats were divided into group given asetosal only in rheumatic arthritis's dose and group given omeprazol preventively then asetoal in rheumatic arthritis's dose. Treatment be given for seven days, then formed peptic ulcer could be evaluated by scoring of ulcer amount and ulcer severity formed and then the datas of the difference beetween two groups are evaluated staticly. Ulcer index each group were determined for determining ulcer damage. The results showed that the effectivity of omeprazol's prevention to peptic ulser side effect of acetosal as an peptic ulser inhibition was 10.68 %.Keywords: NSAID, acetosal, adverse effect, ulcer index

PENGARUH PENGETAHUAN PERPAJAKAN, KUALITAS PELAYANAN FISKUS, DAN SANKSI PERPAJAKAN TERHADAP TINGKAT KEPATUHAN WAJIB PAJAK (STUDI KASUS PADA KPP PRATAMA SURABAYA PABEAN CANTIKAN)

Penelitian ini bertujuan untuk menguji pengaruh pengetahuan perpajakan, kualitas pelayanan fiskus, dan sanksi perpajakan terhadap tingkat kepatuhan wajib pajak (studi kasus pada KPP Pratama Surabaya Pabean Cantikan). Populasi dalam penelitian ini adalah seluruh wajib pajak baik pribadi maupun badan yang terdaftar di KPP Pratama Surabaya Pabean Cantikan. Jenis penelitian ini adalah kuantitatif. Teknik pengambilan sampel menggunakan teknik accidental sampling, yaitu pengumpulan data dari responden yang secara kebetulan bertemu dengan peneliti dan responden yang ditemui dipandang cocok sebagai sumber data. Pengumpulan data primer dilakukan dengan membagikan kuisioner sebanyak 104 kuisioner yang berisi pernyataan untuk dijawab oleh responden, namun hanya 100 kuisioner yang memenuhi persyaratan untuk diolah lebih lanjut. Metode analisis yang digunakan adalah analisis regresi linier berganda dengan alat bantu aplikasi SPSS 25. Hasil penelitian menunjukan bahwa pengetahuan perpajakan berpengaruh positif terhadap tingkat kepatuhan wajib pajak. Kualitas pelayanan berpengaruh positif terhadap tingkat kepatuhan wajib pajak. Sanksi perpajakan berpengaruh positif terhadap tingkat kepatuhan wajib paja

Implementasi Pengendalian Kualitas Menggunakan Metode Statistik Melalui Tahapan Six Sigma pada Pabrik Genteng Bata Good Year Surabaya

Penerapan pengendalian kualitas metode statistik melalui tahapan Six Sigma dengan pola DMAIC bertujuan untuk meningkatkan efisiensi proses bisnis dan sebagai sistem pengukuran untuk memperkecil variasi. Diharapkan dengan penerapan metode statistik melalui tahapan Six Sigma dengan pola DMAIC pada Pabrik Genteng & Bata Good Year Surabaya dapat menjadi strategi perusahaan untuk berkinerja dengan lebih baik. Dari segi akademis penelitian ini diharapkan dapat menjadi panduan atau referensi baik bagi penelitian lebih lanjut ataupun pendalaman pengetahuan terkait dengan metode statistik dan Six Sigma. Penelitian ini menggunakan data cacat produksi selama 3 bulan (April 2011-Juni 2011) dan hanya berfokus pada proses produksi untuk melakukan pengukuran pencapaian tingkatan Sigma pada Pabrik Genteng & Bata Good Year Surabaya dan menghitung nilai RPN menggunakan tabel Failure Mode Effect Analysis (FMEA) untuk dapat memprioritaskan penyebab kegagalan dan menetapkan tindakan perbaikan. Selain menggunakan pola DMAIC, penelitian ini juga menggunakan alat-alat pengendalian kualitas seperti: histogram, diagram pareto, dan cause and effect diagram. Temuan penelitian ini yaitu: (1) tingkat cacat tidak berpola atau tidak menentu, (2) jenis cacat warna tidak standar mendominasi sebesar 39,4%, (3) kinerja proses produksi mendekati pencapaian 4 Sigma, (4) faktor dominan mempengaruhi kinerja perusahaan secara menyeluruh adalah SDM, material dan mesin, oleh karena itu tahap improve berfokus kepada tiga faktor tersebut untuk mengurangi kegagalan cacat produksi

Analysis of the Development Needs for Interactive Web-Based E-book on Pressure Topic for Differentiated Science Learning

This research aims to describe the needs analysis results conducted at SMP Negeri 19 Singkawang as the basis for developing web-based interactive e-book teaching materials on pressure for differentiated science learning. This study is a Research and Development study. The researcher employed a qualitative descriptive research method. Data collection techniques included non-test instruments such as questionnaires, interviews, observations, and documentation. Data analysis was conducted using a qualitative approach. The development of web-based interactive e-books utilized the 4D development model, consisting of four stages: define, design, develop, and disseminate. This study served as a preliminary study in the define stage, where the researcher ensured that the developed product would meet the needs of teachers and students. Based on the findings, students highly demanded web-based interactive e-book media for the topic of pressure. The researcher concluded that students require engaging, interactive teaching materials that can be easily accessed through their frequently used smartphones and contain diverse content with various media formats that cater to their learning styles. Teachers require interactive e-books to enhance the quality of science teaching on the topic of pressure. Differentiated science learning strategies integrated into interactive e-book are necessary for teachers to provide appropriate teaching materials and media that meet the student's learning needs. The availability of supporting facilities and adequate internet connection allows the utilization of web-based interactive e-books on the topic of pressure by students at SMP Negeri 19 Singkawang

Pengukuran Beban Kerja Karyawan Menggunakan Metode NASA-TLX dan CVL Pada Karyawan PT. NIGIL NAL

Hana Ribkah Joe Tabuni, Program Studi Teknik Industri S-1, Fakultas Teknologi Industri Teknologi Nasional Malang, Agustus 2023, Pengukuran Beban Kerja Karyawan Menggunakan Metode NASA-TLX Dan CVL Pada Karyawan PT. Nigil Nal – Di Tembagapura Papua - Indonesia. Dosen Pembimbing I Dr, Prima Vitasari, S.IP.M.Pd dan Dosen Pembimbing II Dra. Sri Indriani, MM. PT. Nigil Nal adalah perusahaan yang beroperasi di bagian environmental khususnya penanaman tanaman tumbuhan di area lingkungan tambang PT. Freeport Indonesia. Perusahaaan ini melakukan pengambilan bibit tanaman secara langsung untuk ditanam. Kemudian untuk target para pekerja harus melakukan pekerjaan secara ekstra sehingga mengalami beban kerja. Penelitian ini merupakan penelitian deskriptif kuantitatif, yaitu melakukan pengukuran beban kerja mental dan fisik pada karyawan di PT. Nigil Nal dengan menggunakan metode NASA–TLX dan Cardiovascular Load (CVL). pengumpulan data pada metode ini menggunakan penyebaran kuisioner maupun perhitungan denyut nadi karyawan yang terdapat 20 orang responden yang digunakan dalam penelitian ini. Hasil penelitian yang diperoleh pada perusahaan tersebut bahwa beban kerja fisik yang paling dominan tinggi adalah karyawan dengan skor 123.39%. Nilai tersebut dalam kategori beban kerja tinggi terhadap karyawan di perusahaan PT. Nigil Nal. maka dari itu diberikan usulan terhadap beban kerja fisik yaitu perlu diberikan alat bantu kerja berupa sekop mini untuk dan gerobak sorong. Kata Kunci: Karyawan, Beban Kerja Mental NASA-TLX dan Beban Kerja Fisik Cardiovaskularloa

DIGITAL LITERACY AMONG TEACHERS IN SINGKAWANG CITY: AN ANALYSIS OF GENDER, AGE, AND SOCIO-ECONOMIC STATUS

One of the demands of teachers in Generation Z is being able to have digital literacy content that supports their functions and work. There is no research related to the influence of gender, age, and socioeconomic status on digital literacy competency teachers in Singkawang City. This study aims to review whether there are significant differences in teachers' digital literacy abilities in terms of gender, socioeconomic status aspects of those who are able, moderate, or poor, and the age of teachers in different generations. This research method includes the descriptive quantitative inferential survey method. The number of volunteer respondents as research subjects was 200 teachers from 50 elementary and junior high schools who taught in Singkawang City and were selected by the voluntary response sampling technique. Data collection used a questionnaire instrument for teachers that contained 17 items that had been proven valid. Data were analyzed using the Mann-Whitney test for gender and the Kruskal-Wallish H test for age and socioeconomic status. The results showed that (1) the significance value was 0.063 > 0.005, which did not show a significant difference between teachers' digital literacy skills based on gender; (2) the significance value was 0.075 > 0.05, meaning that there was no difference in teachers' digital literacy seen from socioeconomic status (able, moderate, and underprivileged); and (3) the significance value is 0.106 > 0.05, indicating that there is no difference between teachers whose age includes the baby boomers generation, generation X, and the millennial generatio

Analysis of the Development Needs for Interactive Web-Based E-book on Pressure Topic for Differentiated Science Learning

This research aims to describe the needs analysis results conducted at SMP Negeri 19 Singkawang as the basis for developing web-based interactive e-book teaching materials on pressure for differentiated science learning. This study is a Research and Development study. The researcher employed a qualitative descriptive research method. Data collection techniques included non-test instruments such as questionnaires, interviews, observations, and documentation. Data analysis was conducted using a qualitative approach. The development of web-based interactive e-books utilized the 4D development model, consisting of four stages: define, design, develop, and disseminate. This study served as a preliminary study in the define stage, where the researcher ensured that the developed product would meet the needs of teachers and students. Based on the findings, students highly demanded web-based interactive e-book media for the topic of pressure. The researcher concluded that students require engaging, interactive teaching materials that can be easily accessed through their frequently used smartphones and contain diverse content with various media formats that cater to their learning styles. Teachers require interactive e-books to enhance the quality of science teaching on the topic of pressure. Differentiated science learning strategies integrated into interactive e-book are necessary for teachers to provide appropriate teaching materials and media that meet the student's learning needs. The availability of supporting facilities and adequate internet connection allows the utilization of web-based interactive e-books on the topic of pressure by students at SMP Negeri 19 Singkawang

Peran Sistem Informasi Manajemen dalam Pengelolaan Administrasi Pegawai di Badan Kepegawaian Daerah Provinsi Sulawesi Utara

In the present era of government began to implement the e-government program. Thelast few years the government has been utilizing technological advances in various activities,including the public service based on information technology gained recognition. RegionalPersonnel Agency (BKD) North Sulawesi Province. The agency is an agency that already usepersonnel information system to process data and information and decision-making for specificsituations such as a promotion, a raise, a shift or mutation, and other relevant rules. Data andinformation is confidential and prudence. The method used in this research is qualitative research.Then, for the data used consist of primary data and secondary data. With the technique ofcollecting data through observation, interviews, and documentation. Data obtained from varioussources and has analyzed, with several stages of data reduction, data presentation, andconclusion. Researchers infer from each corner of the data and information administration,employment applications, employee capability, equipment for the system, every administrativeprocedure. Researchers conclude that the management information system has been running welland answer the problem formulation management information system is a collection of elementsthat are interconnected with each other to form a single unit to integrate data, process and storeand distribute information. At the Regional Employment Board of North Sulawesi these elements isthe data and information of employees, employment applications, employee, equipment for thesystems, and procedures for the administration. These elements are intertwined to be able tomanage and deliver the results to the administration required

ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEMAMPUAN ADAPTASI MEDICAL SALES REPRESENTATIVES. DALAM MENJUAL UNTUK MENINGKATKAN KINERJANYA (Slid Tongan Ma Industri Farmasi Di Kota Semarang)

Salespeople is an important resources of the firms in creating good relationship between the firms and the consumers. Beside creating good relationship, they also face a lot of consumer's characteristics, behaviour and need in selling. Therefore adaptiveness selling is an important condition for salespeople to increase their's performance. The aims of this research is to analyze interaction involvement, self-monitoring and learning orientation influencing medical sales representatives adaptiveness selling to increase its performance. Sample of this research are pharmacy industry medical sales representatif in Semarang. Data was analyzed with Structural Equation Model (SEM) by using AMOS 4.01 program. The result of data analyzes show that all hypotesis are proved, thus, the conclusions are the interaction involvement, self-monitoring and learning orientation influences positively in medical saleS representatives adaptiveness selling, and the adaptiveness selling influences positively in medical sales representatif performance. The measurement testes are fulfilling goodness of fit criteria; CHI-Square = 193.037; Probability = 0.054; CMIN/DF = 1.184; RMSEA = 0.037; GFI = 0.879; AGFI = 0.844; TLI = 0.987; CFI = 0.989. This research also related the result with theoritical and mangerial implication. Limitation of this research and agenda of the future research can be used as a reference by next researchers. Salespeole adalah sumber daya yang penting bagi perusahaan dan menjadi jembatan penghubung antara perusahaan dan konsumen. Disamping, menjadi jembatan penghubung, salespeole juga diharuskan untuk menghadapi bermacam-macam karakteristik, perilaku dan kebutuhan dari konsumen. Oleh sebab itu kemampuan beradaptasi dalam menjual merupakan kondisi yang penting bagi salespeole untuk meningkatkan kinerjanya. Tujuan penelitian ini adalah untuk menganalisis faktor keterlibatan dalam interaksi, faktor self-monitoring, dan faktor orientasi belajar yang mempengaruhi kemampuan adaptasi medical sales representative dalam menjual untuk meningkatkan kinerjanya. Penelitian ini menggunakan medical sales representative industri farmasi di kota semarang sebagai sampel. Data penelitian ini dianalisis dengan menggunakan Structural Equation Model (SEM) dari paket Statistik AMOS 4.01. Hasil dan analisis data menunjukkan bahwa semua hipotesis terbukti, dengan kesimpulan bahwa keterlibatan dalam interaksi, self-monitoring, dan orientasi belajar berpengaruh positif terhadap kemampuan adaptasi medical sales representative dalam menjual, dan kemampuan adaptasi medical sales representative dalam menjual berpengaruh positif terhadap kinerjanya. Adapun hash pengukuran telah memenuhi kriteria Goodness of fit; CM-square = 193.037; Probabilitas = 0.054; CMEN/DF = 1.184; RMSEA = 0.037; GFI = 0.879; AGFI = 0.844; TLI = 0.987; CFI = 0.989. Penelitian ini menghubungkan antara hash penelitian dengan implikasi teoritis dan implikasi manjerial. Keterbatasan penelitian dan agenda penelitian mendatang dapat dijadikan referensi bagi peneliti-peneliti selanjutnya