Clinical Social Work Practice in America: Has it Maintained its Ethical Core?

The purpose of this study was to identify if there is an ongoing dilemma relating to the ethical core values of the current practice of clinical social work in America. The conceptual framework for this study is based on a qualitative paradigm consisting of a synthesis of existing research and the subjective data that was collected and analyzed for the purpose of this research study. This study reveals an ongoing polarized view of the perceived priorities of the ethical constructs of clinical social work as practiced in America over the last 40 years. This study reflects the need for clarification, as well as further research on the part of the National Association of Social Workers, as the NASW hopefully moves forward and provides a more comprehensive and clearly defined national policy regarding the current construct of the ethical model of clinical social work practice

Clinical Social Work Practice in America: Has it Maintained its Ethical Core?

The purpose of this study was to identify if there is an ongoing dilemma relating to the ethical core values of the current practice of clinical social work in America. The conceptual framework for this study is based on a qualitative paradigm consisting of a synthesis of existing research and the subjective data that was collected and analyzed for the purpose of this research study. This study reveals an ongoing polarized view of the perceived priorities of the ethical constructs of clinical social work as practiced in America over the last 40 years. This study reflects the need for clarification, as well as further research on the part of the National Association of Social Workers, as the NASW hopefully moves forward and provides a more comprehensive and clearly defined national policy regarding the current construct of the ethical model of clinical social work practice

Using Intelligent Prefetching to Reduce the Energy Consumption of a Large-scale Storage System

Many high performance large-scale storage systems will experience significant workload increases as their user base and content availability grow over time. The U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) center hosts one such system that has recently undergone a period of rapid growth as its user population grew nearly 400% in just about three years. When administrators of these massive storage systems face the challenge of meeting the demands of an ever increasing number of requests, the easiest solution is to integrate more advanced hardware to existing systems. However, additional investment in hardware may significantly increase the system cost as well as daily power consumption. In this paper, we present evidence that well-selected software level optimization is capable of achieving comparable levels of performance without the cost and power consumption overhead caused by physically expanding the system. Specifically, we develop intelligent prefetching algorithms that are suitable for the unique workloads and user behaviors of the world\u27s largest satellite images distribution system managed by USGS EROS. Our experimental results, derived from real-world traces with over five million requests sent by users around the globe, show that the EROS hybrid storage system could maintain the same performance with over 30% of energy savings by utilizing our proposed prefetching algorithms, compared to the alternative solution of doubling the size of the current FTP server farm

Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men

We hypothesized that an increased, incomplete fatty acid beta‐oxidation in mitochondria could be part of the metabolic events leading to insulin resistance and thereby an increased type 2 diabetes risk in low birth weight (LBW) compared with normal birth weight (NBW) individuals. Therefore, we measured fasting plasma levels of 45 acylcarnitine species in 18 LBW and 25 NBW men after an isocaloric control diet and a 5‐day high‐fat, high‐calorie diet. We demonstrated that LBW men had higher C2 and C4‐OH levels after the control diet compared with NBW men, indicating an increased fatty acid beta‐oxidation relative to the tricarboxylic acid cycle flux. Also, they had higher C6‐DC, C10‐OH/C8‐DC, and total hydroxyl‐/dicarboxyl‐acylcarnitine levels, which may suggest an increased fatty acid omega‐oxidation in the liver. Furthermore, LBW and NBW men decreased several acylcarnitine levels in response to overfeeding, which is likely a result of an upregulation of fatty acid oxidation due to the dietary challenge. Moreover, C10‐OH/C8‐DC and total hydroxyl‐/dicarboxyl‐acylcarnitine levels tended to be negatively associated with the serum insulin level, and the total hydroxyl‐/dicarboxyl‐acylcarnitine level additionally tended to be negatively associated with the hepatic insulin resistance index. This indicates that an increased fatty acid omega‐oxidation could be a compensatory mechanism to prevent an accumulation of lipid species that impair insulin signaling

Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding

Low birth weight (LBW) individuals exhibit a disproportionately increased, incomplete fatty acid oxidation and a decreased glucose oxidation, compared with normal birth weight (NBW) individuals, and furthermore have an increased risk of developing insulin resistance and type 2 diabetes. We hypothesized that changes in amino acid metabolism may occur parallel to alterations in fatty acid and glucose oxidation, and could contribute to insulin resistance. Therefore, we measured fasting plasma levels of 15 individual or pools of amino acids in 18 LBW and 25 NBW men after an isocaloric control diet and after a 5‐day high‐fat, high‐calorie diet. We demonstrated that LBW and NBW men increased plasma alanine levels and decreased valine and leucine/isoleucine levels in response to overfeeding. Also, LBW men had higher alanine, proline, methionine, citrulline, and total amino acid levels after overfeeding compared with NBW men. Alanine and total amino acid levels tended to be negatively associated with the insulin‐stimulated glucose uptake after overfeeding. Therefore, the higher amino acid levels in LBW men could be a consequence of their reduction in skeletal muscle insulin sensitivity due to overfeeding with a possible increased skeletal muscle proteolysis and/or could potentially contribute to an impaired insulin sensitivity. Furthermore, the alanine level was negatively associated with the plasma acetylcarnitine level and positively associated with the hepatic glucose production after overfeeding. Thus, the higher alanine level in LBW men could be accompanied by an increased anaplerotic formation of oxaloacetate and thereby an enhanced tricarboxylic acid cycle activity and as well an increased gluconeogenesis

Plasma ceramide levels are altered in low and normal birth weight men in response to short-term high-fat overfeeding

AbstractLow birth weight (LBW) individuals have an increased risk of developing insulin resistance and type 2 diabetes compared with normal birth weight (NBW) individuals. We hypothesised that LBW individuals exhibit an increased fatty acid flux into lipogenesis in non-adipose tissue with a resulting accumulation of lipotoxic lipids, including ceramides, in the blood. Therefore, we measured fasting plasma levels of 27 ceramides in 18 young, healthy, LBW men and 25 NBW controls after an isocaloric control diet and a 5-day high-fat, high-calorie diet by HPLC-HRMS. LBW men did not show elevated plasma ceramide levels after the control or high-fat, high-calorie diet. An increased fatty acid oxidation rate in these individuals during both diets may limit ceramide synthesis and thereby compensate for a likely increased fatty acid load to non-adipose tissue. Interestingly, LBW and NBW men decreased d18:0–18:1/d18:1–18:0 and d18:1–24:2/d18:2–24:1 levels and increased the d18:0–24:1a level in response to overfeeding. Plasma d18:0–24:1a and total ceramide levels were positively associated with the fasting blood glucose level and endogenous glucose production after the control diet, and the total ceramide level was in addition positively associated with hepatic insulin resistance. Further studies are needed to determine if lipotoxicity contributes to insulin resistance in LBW individuals.</jats:p