Interpretive Approaches to British Government and Politics

This paper has two aims. First, in contrast to the modernist empiricism of mainstream political science, we provide brief introductions to several interpretive approaches to the study of political science and British government and politics: idealism, social humanism, post-structuralism, and ideational institutionalism. Second, we identify the distinctive research agendas that arise from this family of approaches: namely, critique, decentring governance, ethnographic studies of British politics, and policy analysis as storytelling

ReseArch with Patient and Public invOlvement: a RealisT evaluation - the RAPPORT study

Background Patient and public involvement (PPI) is a prerequisite for many funding bodies and NHS research ethics approval. PPI in research is defined as research carried out with or by the public rather than to, about or for them. While the benefits of PPI have been widely discussed, there is a lack of evidence on the impact and outcomes of PPI in research. Objectives To determine the types of PPI in funded research, describe key processes, analyse the contextual and temporal dynamics of PPI and explore the experience of PPI in research for all those involved. Mechanisms contributing to the routine incorporation of PPI in the research process were assessed, the impact of PPI on research processes and outcomes evaluated, and barriers and enablers to effective PPI identified. Design A three-staged realist evaluation drawing on Normalisation Process Theory to understand how far PPI was embedded within health-care research in six areas: diabetes mellitus, arthritis, cystic fibrosis, dementia, public health and learning disabilities. The first two stages comprised a scoping exercise and online survey to chief investigators to assess current PPI activity. The third stage consisted of case studies tracked over 18 months through interviews and document analysis. The research was conducted in four regions of England. Participants Non-commercial studies currently running or completed within the previous 2 years eligible for adoption on the UK Clinical Research Network portfolio. A total of 129 case study participants included researchers and PPI representatives from 22 research studies, and representatives from funding bodies and PPI networks

Salmonella Strains Isolated from Galápagos Iguanas Show Spatial Structuring of Serovar and Genomic Diversity

It is thought that dispersal limitation primarily structures host-associated bacterial populations because host distributions inherently limit transmission opportunities. However, enteric bacteria may disperse great distances during food-borne outbreaks. It is unclear if such rapid long-distance dispersal events happen regularly in natural systems or if these events represent an anthropogenic exception. We characterized Salmonella enterica isolates from the feces of free-living Galápagos land and marine iguanas from five sites on four islands using serotyping and genomic fingerprinting. Each site hosted unique and nearly exclusive serovar assemblages. Genomic fingerprint analysis offered a more complex model of S. enterica biogeography, with evidence of both unique strain pools and of spatial population structuring along a geographic gradient. These findings suggest that even relatively generalist enteric bacteria may be strongly dispersal limited in a natural system with strong barriers, such as oceanic divides. Yet, these differing results seen on two typing methods also suggests that genomic variation is less dispersal limited, allowing for different ecological processes to shape biogeographical patterns of the core and flexible portions of this bacterial species' genome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Everyday Life in a Ministry; public administration as Anthropology

This article seeks to answer two questions: What do we know about the work of ministers and permanent secretaries? How do we know what we know about ministers and permanent secretaries? To do so, it describes a research project on life at the top of British government departments and discusses the issues raised by trying to do research and write a political anthropology of the daily life of ministers and civil servants. The article has four sections. First, it surveys briefly the existing literature on ministers and top civil servants. Second, it describes the scope and methods of the project. Third, it reports some early findings. Finally, it reflects on the distinctive contribution of ethnographic research to understanding British government and the problems of elite interviewing, nonparticipant observation, and research on the powerful

Everyday life in British Government

As citizens, why do we care about the everyday life of ministers and civil servants? We care because the decisions of the great and the good affect all our lives, for good or ill. For all their personal, political, and policy failings and foibles, they make a difference. So, we want to know what ministers and bureaucrats do, why, and how. We are interested in their beliefs and practices. In his fascinating piece of political anthropology, Rod Rhodes uncovers exactly how the British political elite thinks and acts. Drawing on unprecedented access to ministers and senior civil servants in three government departments, he answers a simple question: 'what do they do?' On the basis of extensive fieldwork, supplemented by revealing interviews, he tries to capture the essence of their everyday life. He describes the ministers' and permanent secretaries' world through their own eyes, and explores how their beliefs and practices serve to create meaning in politics, policy making, and public-service delivery. He goes on to analyze how such beliefs and practices are embedded in traditions; in webs of protocols, rituals, and languages. The story he has to tell is dramatized through in-depth accounts of specific events to show ministers and civil servants 'in action'. He challenges the conventional constitutional, institutional, and managerial views of British governance. Instead, he describes a storytelling political-administrative elite, with beliefs and practices rooted in the Westminster model, which uses protocols and rituals to domesticate rude surprises and cope with recurrent dilemmas.Readership: Scholars and students of Political Science, British Politics, Public Administration, and Political Institutions. <br/